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Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.

Zhang X, Brann TW, Zhou M, Yang J, Oguariri RM, Lidie KB, Imamichi H, Huang DW, Lempicki RA, Baseler MW, Veenstra TD, Young HA, Lane HC, Imamichi T.

J Immunol. 2011 Apr 15;186(8):4541-5. doi: 10.4049/jimmunol.1003389. Epub 2011 Mar 11.


Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.

Nolens G, Pignon JC, Koopmansch B, Elmoualij B, Zorzi W, De Pauw E, Winkler R.

Breast Cancer Res. 2009;11(6):R83. doi: 10.1186/bcr2450. Epub 2009 Nov 11.


IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.

Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, Wang Q, Bai L, Liu Y, Wu K, Wu J.

J Immunol. 2014 Jan 15;192(2):691-703. doi: 10.4049/jimmunol.1300252. Epub 2013 Dec 11.


Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.

Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura Y, Imai K, Hirohashi S, Yamada T.

Cancer Res. 2007 Feb 1;67(3):911-8.


Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells.

Shi L, Qiu D, Zhao G, Corthesy B, Lees-Miller S, Reeves WH, Kao PN.

Nucleic Acids Res. 2007;35(7):2302-10. Epub 2007 Mar 27.


Accumulation of Ku80 proteins at DNA double-strand breaks in living cells.

Koike M, Koike A.

Exp Cell Res. 2008 Mar 10;314(5):1061-70. doi: 10.1016/j.yexcr.2007.11.014. Epub 2007 Nov 28.


Nuclear loss of DNA repair Ku proteins and c-myc expression in apoptosis of cerulein-stimulated pancreatic acinar cells.

Yu JH, Kim KH, Kim H.

Inflammopharmacology. 2007 Dec;15(6):282-7. doi: 10.1007/s10787-007-1588-y.


Molecular analysis of Ku redox regulation.

Bennett SM, Neher TM, Shatilla A, Turchi JJ.

BMC Mol Biol. 2009 Aug 28;10:86. doi: 10.1186/1471-2199-10-86.


IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes.

Osterlund PI, Pietilä TE, Veckman V, Kotenko SV, Julkunen I.

J Immunol. 2007 Sep 15;179(6):3434-42.


Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo.

Li GC, He F, Shao X, Urano M, Shen L, Kim D, Borrelli M, Leibel SA, Gutin PH, Ling CC.

Cancer Res. 2003 Jun 15;63(12):3268-74.


The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response.

Brenkman AB, van den Broek NJ, de Keizer PL, van Gent DC, Burgering BM.

FASEB J. 2010 Nov;24(11):4271-80. doi: 10.1096/fj.10-158717. Epub 2010 Jun 22.


Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription.

Bertinato J, Tomlinson JJ, Schild-Poulter C, Haché RJ.

Gene. 2003 Jan 2;302(1-2):53-64.


MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-λ1.

Li Y, Xie J, Xu X, Wang J, Ao F, Wan Y, Zhu Y.

Protein Cell. 2013 Feb;4(2):130-41. doi: 10.1007/s13238-012-2081-y. Epub 2012 Nov 12.


Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells.

Song JY, Lim JW, Kim H, Morio T, Kim KH.

J Biol Chem. 2003 Sep 19;278(38):36676-87. Epub 2003 Jul 16.


KARP-1 works as a heterodimer with Ku70, but the function of KARP-1 cannot perfectly replace that of Ku80 in DSB repair.

Koike M, Yutoku Y, Koike A.

Exp Cell Res. 2011 Oct 1;317(16):2267-75. doi: 10.1016/j.yexcr.2011.06.015. Epub 2011 Jul 2.


Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P.

PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014.


STING is an essential mediator of the Ku70-mediated production of IFN-λ1 in response to exogenous DNA.

Sui H, Zhou M, Imamichi H, Jiao X, Sherman BT, Lane HC, Imamichi T.

Sci Signal. 2017 Jul 18;10(488). pii: eaah5054. doi: 10.1126/scisignal.aah5054.


Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3).

Yoneyama M, Suhara W, Fukuhara Y, Sato M, Ozato K, Fujita T.

J Biochem. 1996 Jul;120(1):160-9.


DNA demethylation in retinal neurocytes contributes to the upregulation of DNA repair protein, Ku80.

Zhuang J, Ye Y, Liu X, Li F, Pan X, Chen Z, Luo H, Ge Y, Ge J, Kaminski J, Yu K.

Neuroreport. 2010 Mar 10;21(4):282-6. doi: 10.1097/WNR.0b013e328336ee7e.


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