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Items: 1 to 20 of 119

1.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ.

Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.

2.

Medicine. Progranulin resolves inflammation.

Wu H, Siegel RM.

Science. 2011 Apr 22;332(6028):427-8. doi: 10.1126/science.1205992. No abstract available.

3.

Progranulin: a growth factor, a novel TNFR ligand and a drug target.

Liu CJ, Bosch X.

Pharmacol Ther. 2012 Jan;133(1):124-32. doi: 10.1016/j.pharmthera.2011.10.003. Epub 2011 Oct 8. Review.

4.

Progranulin: a promising therapeutic target for rheumatoid arthritis.

Liu CJ.

FEBS Lett. 2011 Dec 1;585(23):3675-80. doi: 10.1016/j.febslet.2011.04.065. Epub 2011 May 4. Review.

5.

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.

Tian Q, Zhao Y, Mundra JJ, Gonzalez-Gugel E, Jian J, Uddin SM, Liu C.

Front Biosci (Landmark Ed). 2014 Jun 1;19:1176-85.

6.

The role of progranulin in arthritis.

Wei J, Hettinghouse A, Liu C.

Ann N Y Acad Sci. 2016 Nov;1383(1):5-20. doi: 10.1111/nyas.13191. Epub 2016 Aug 9. Review.

PMID:
27505256
7.

Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

McCann FE, Perocheau DP, Ruspi G, Blazek K, Davies ML, Feldmann M, Dean JL, Stoop AA, Williams RO.

Arthritis Rheumatol. 2014 Oct;66(10):2728-38. doi: 10.1002/art.38755.

8.

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.

Zhao YP, Liu B, Tian QY, Wei JL, Richbourgh B, Liu CJ.

Ann Rheum Dis. 2015 Dec;74(12):2244-2253. doi: 10.1136/annrheumdis-2014-205779. Epub 2014 Aug 28.

9.

Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.

Zhao YP, Tian QY, Liu CJ.

FEBS Lett. 2013 Jun 19;587(12):1805-10. doi: 10.1016/j.febslet.2013.04.037. Epub 2013 May 10.

10.

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling.

Zhao YP, Tian QY, Frenkel S, Liu CJ.

Biomaterials. 2013 Sep;34(27):6412-21. doi: 10.1016/j.biomaterials.2013.05.030. Epub 2013 Jun 5.

11.

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.

Wei F, Zhang Y, Jian J, Mundra JJ, Tian Q, Lin J, Lafaille JJ, Tang W, Zhao W, Yu X, Liu CJ.

Sci Rep. 2014 Nov 12;4:7023. doi: 10.1038/srep07023.

12.

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.

Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV Jr, Kukar T, Tansey MG.

J Neurosci. 2013 May 22;33(21):9202-13. doi: 10.1523/JNEUROSCI.5336-12.2013.

13.

New discovery rarely runs smooth: an update on progranulin/TNFR interactions.

Wang BC, Liu H, Talwar A, Jian J.

Protein Cell. 2015 Nov;6(11):792-803. doi: 10.1007/s13238-015-0213-x. Epub 2015 Sep 25. Review.

14.

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains.

Jian J, Zhao S, Tian Q, Gonzalez-Gugel E, Mundra JJ, Uddin SM, Liu B, Richbourgh B, Brunetti R, Liu CJ.

FEBS Lett. 2013 Nov 1;587(21):3428-36. doi: 10.1016/j.febslet.2013.09.024. Epub 2013 Sep 23.

15.

Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model.

Westlund KN, Zhang L, Ma F, Oz HS.

Transl Res. 2012 Jul;160(1):84-94. doi: 10.1016/j.trsl.2011.10.003. Epub 2011 Nov 8.

16.

Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner.

Mundra JJ, Jian J, Bhagat P, Liu CJ.

Sci Rep. 2016 Feb 19;6:21115. doi: 10.1038/srep21115.

17.

The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.

Abella V, Scotece M, Conde J, López V, Pirozzi C, Pino J, Gómez R, Lago F, González-Gay MÁ, Gualillo O.

Sci Rep. 2016 Feb 8;6:20356. doi: 10.1038/srep20356.

18.

Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity.

Liu C, Li XX, Gao W, Liu W, Liu DS.

PLoS One. 2014 Mar 20;9(3):e92743. doi: 10.1371/journal.pone.0092743. eCollection 2014.

19.

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.

Hu Y, Xiao H, Shi T, Oppenheim JJ, Chen X.

Immunology. 2014 Jun;142(2):193-201. doi: 10.1111/imm.12241.

20.

Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.

Deng GM, Zheng L, Chan FK, Lenardo M.

Nat Med. 2005 Oct;11(10):1066-72. Epub 2005 Sep 18.

PMID:
16170321

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