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Items: 1 to 20 of 133


The Werner syndrome protein: linking the replication checkpoint response to genome stability.

Pichierri P, Ammazzalorso F, Bignami M, Franchitto A.

Aging (Albany NY). 2011 Mar;3(3):311-8. Review.


ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.

Ammazzalorso F, Pirzio LM, Bignami M, Franchitto A, Pichierri P.

EMBO J. 2010 Sep 15;29(18):3156-69. doi: 10.1038/emboj.2010.205. Epub 2010 Aug 27.


Interplay between wrn and the checkpoint in s-phase.

Pichierri P.

Ital J Biochem. 2007 Jun;56(2):130-40. Review.


The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.

Pichierri P, Nicolai S, Cignolo L, Bignami M, Franchitto A.

Oncogene. 2012 Jun 7;31(23):2809-23. doi: 10.1038/onc.2011.468. Epub 2011 Oct 17.


WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.

Patro BS, Frøhlich R, Bohr VA, Stevnsner T.

J Cell Sci. 2011 Dec 1;124(Pt 23):3967-79. doi: 10.1242/jcs.081372. Epub 2011 Dec 8.


WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA.

Mol Biol Cell. 2008 Sep;19(9):3923-33. doi: 10.1091/mbc.E07-07-0698. Epub 2008 Jul 2.


The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.

Lee SJ, Gartner A, Hyun M, Ahn B, Koo HS.

PLoS Genet. 2010 Jan;6(1):e1000801. doi: 10.1371/journal.pgen.1000801. Epub 2010 Jan 8.


Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.

Basile G, Leuzzi G, Pichierri P, Franchitto A.

Nucleic Acids Res. 2014 Nov 10;42(20):12628-39. doi: 10.1093/nar/gku1022. Epub 2014 Oct 28.


WRN participates in translesion synthesis pathway through interaction with NBS1.

Kobayashi J, Okui M, Asaithamby A, Burma S, Chen BP, Tanimoto K, Matsuura S, Komatsu K, Chen DJ.

Mech Ageing Dev. 2010 Jun;131(6):436-44. doi: 10.1016/j.mad.2010.06.005. Epub 2010 Jun 17.


Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway.

Su F, Bhattacharya S, Abdisalaam S, Mukherjee S, Yajima H, Yang Y, Mishra R, Srinivasan K, Ghose S, Chen DJ, Yannone SM, Asaithamby A.

Oncotarget. 2016 Jan 5;7(1):46-65. doi: 10.18632/oncotarget.6659.


Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.

Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, Baynton K, Bohr VA.

J Cell Sci. 2006 Dec 15;119(Pt 24):5137-46. Epub 2006 Nov 21. Erratum in: J Cell Sci. 2006 Dec 15;119(Pt 24):5215.


Roles of the Werner syndrome RecQ helicase in DNA replication.

Sidorova JM.

DNA Repair (Amst). 2008 Nov 1;7(11):1776-86. doi: 10.1016/j.dnarep.2008.07.017. Epub 2008 Sep 6. Review.


The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.

Sidorova JM, Li N, Folch A, Monnat RJ Jr.

Cell Cycle. 2008 Mar 15;7(6):796-807. Epub 2008 Jan 4.


Functional role of the Werner syndrome RecQ helicase in human fibroblasts.

Dhillon KK, Sidorova J, Saintigny Y, Poot M, Gollahon K, Rabinovitch PS, Monnat RJ Jr.

Aging Cell. 2007 Feb;6(1):53-61.


Werner syndrome helicase activity is essential in maintaining fragile site stability.

Pirzio LM, Pichierri P, Bignami M, Franchitto A.

J Cell Biol. 2008 Jan 28;180(2):305-14. doi: 10.1083/jcb.200705126. Epub 2008 Jan 21.


The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.

Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD.

J Biol Chem. 2008 Sep 5;283(36):24478-83. doi: 10.1074/jbc.M803370200. Epub 2008 Jul 2.


Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.

Machwe A, Lozada E, Wold MS, Li GM, Orren DK.

J Biol Chem. 2011 Feb 4;286(5):3497-508. doi: 10.1074/jbc.M110.105411. Epub 2010 Nov 24.


Premature aging syndrome gene WRN genetically interacts with a topoisomerase.

Aggarwal M, Brosh RM Jr.

Cell Cycle. 2009 Jul 15;8(14):2143. Epub 2009 Jul 15. No abstract available.


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