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Items: 1 to 20 of 143

1.

Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.

Urakawa H, Nishida Y, Wasa J, Arai E, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N.

Int J Cancer. 2012 Jan 15;130(2):454-66. doi: 10.1002/ijc.26014.

2.

Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer.

Urakawa H, Nishida Y, Knudson W, Knudson CB, Arai E, Kozawa E, Futamura N, Wasa J, Ishiguro N.

J Orthop Res. 2012 Apr;30(4):662-72. doi: 10.1002/jor.21557.

3.

Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production.

Hiraga T, Ito S, Nakamura H.

Cancer Res. 2013 Jul 1;73(13):4112-22. doi: 10.1158/0008-5472.CAN-12-3801.

4.

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

Kultti A, Pasonen-Seppänen S, Jauhiainen M, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI.

Exp Cell Res. 2009 Jul 1;315(11):1914-23. doi: 10.1016/j.yexcr.2009.03.002.

PMID:
19285976
5.

4-methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells.

Saito T, Tamura D, Nakamura T, Makita Y, Ariyama H, Komiyama K, Yoshihara T, Asano R.

Oncol Rep. 2013 Jan;29(1):335-42. doi: 10.3892/or.2012.2100.

PMID:
23124556
6.

Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo.

Arai E, Nishida Y, Wasa J, Urakawa H, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N.

Br J Cancer. 2011 Dec 6;105(12):1839-49. doi: 10.1038/bjc.2011.459.

7.

Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells.

Lokeshwar VB, Lopez LE, Munoz D, Chi A, Shirodkar SP, Lokeshwar SD, Escudero DO, Dhir N, Altman N.

Cancer Res. 2010 Apr 1;70(7):2613-23. doi: 10.1158/0008-5472.CAN-09-3185.

8.

The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity.

Qin J, Kilkus J, Dawson G.

Biochim Biophys Acta. 2016 Feb;1861(2):78-90. doi: 10.1016/j.bbalip.2015.11.001.

9.

HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells.

Tofuku K, Yokouchi M, Murayama T, Minami S, Komiya S.

Int J Oncol. 2006 Jul;29(1):175-83.

PMID:
16773198
10.

Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.

Twarock S, Freudenberger T, Poscher E, Dai G, Jannasch K, Dullin C, Alves F, Prenzel K, Knoefel WT, Stoecklein NH, Savani RC, Homey B, Fischer JW.

Mol Cancer. 2011 Mar 23;10:30. doi: 10.1186/1476-4598-10-30.

11.

Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells.

Li L, Qi L, Liang Z, Song W, Liu Y, Wang Y, Sun B, Zhang B, Cao W.

Int J Mol Med. 2015 Jul;36(1):113-22. doi: 10.3892/ijmm.2015.2222.

12.

Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice.

Piccioni F, Malvicini M, Garcia MG, Rodriguez A, Atorrasagasti C, Kippes N, Piedra Buena IT, Rizzo MM, Bayo J, Aquino J, Viola M, Passi A, Alaniz L, Mazzolini G.

Glycobiology. 2012 Mar;22(3):400-10. doi: 10.1093/glycob/cwr158.

PMID:
22038477
13.

A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone.

Kakizaki I, Kojima K, Takagaki K, Endo M, Kannagi R, Ito M, Maruo Y, Sato H, Yasuda T, Mita S, Kimata K, Itano N.

J Biol Chem. 2004 Aug 6;279(32):33281-9.

14.

Hyaluronan synthesis inhibitor supplements the inhibitory effects of zoledronic acid on bone metastasis of lung cancer.

Futamura N, Urakawa H, Arai E, Kozawa E, Ishiguro N, Nishida Y.

Clin Exp Metastasis. 2013 Jun;30(5):595-606. doi: 10.1007/s10585-012-9563-4.

PMID:
23288481
15.

Antitumor effects of hyaluronan inhibition in desmoid tumors.

Briggs A, Rosenberg L, Buie JD, Rizvi H, Bertagnolli MM, Cho NL.

Carcinogenesis. 2015 Feb;36(2):272-9. doi: 10.1093/carcin/bgu324.

PMID:
25556151
16.

Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL).

Morohashi H, Kon A, Nakai M, Yamaguchi M, Kakizaki I, Yoshihara S, Sasaki M, Takagaki K.

Biochem Biophys Res Commun. 2006 Jul 14;345(4):1454-9.

PMID:
16730656
17.

The effects of 4-methylumbelliferone on hyaluronan synthesis, MMP2 activity, proliferation, and motility of human aortic smooth muscle cells.

Vigetti D, Rizzi M, Viola M, Karousou E, Genasetti A, Clerici M, Bartolini B, Hascall VC, De Luca G, Passi A.

Glycobiology. 2009 May;19(5):537-46. doi: 10.1093/glycob/cwp022.

PMID:
19240269
18.

Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.

Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.

Arthritis Rheum. 2013 May;65(5):1160-70. doi: 10.1002/art.37861.

19.

4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors.

Edward M, Quinn JA, Pasonen-Seppänen SM, McCann BA, Tammi RH.

Br J Dermatol. 2010 Jun;162(6):1224-32. doi: 10.1111/j.1365-2133.2010.09699.x.

PMID:
20163414
20.

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.

Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clézardin P, Papapoulos SE, Cecchini MG, Löwik CW, van der Pluijm G.

Cancer Res. 2007 Sep 15;67(18):8742-51.

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