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Items: 1 to 20 of 114


Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine.

Suk JS, Lai SK, Boylan NJ, Dawson MR, Boyle MP, Hanes J.

Nanomedicine (Lond). 2011 Feb;6(2):365-75. doi: 10.2217/nnm.10.123.


N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles.

Suk JS, Boylan NJ, Trehan K, Tang BC, Schneider CS, Lin JM, Boyle MP, Zeitlin PL, Lai SK, Cooper MJ, Hanes J.

Mol Ther. 2011 Nov;19(11):1981-9. doi: 10.1038/mt.2011.160. Epub 2011 Aug 9.


The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.

Suk JS, Lai SK, Wang YY, Ensign LM, Zeitlin PL, Boyle MP, Hanes J.

Biomaterials. 2009 May;30(13):2591-7. doi: 10.1016/j.biomaterials.2008.12.076. Epub 2009 Jan 26.


Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.

Tang BC, Dawson M, Lai SK, Wang YY, Suk JS, Yang M, Zeitlin P, Boyle MP, Fu J, Hanes J.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19268-73. doi: 10.1073/pnas.0905998106. Epub 2009 Nov 9.


Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients.

Hida K, Lai SK, Suk JS, Won SY, Boyle MP, Hanes J.

PLoS One. 2011;6(5):e19919. doi: 10.1371/journal.pone.0019919. Epub 2011 May 27.


Nanoparticle penetration of human cervicovaginal mucus: the effect of polyvinyl alcohol.

Yang M, Lai SK, Yu T, Wang YY, Happe C, Zhong W, Zhang M, Anonuevo A, Fridley C, Hung A, Fu J, Hanes J.

J Control Release. 2014 Oct 28;192:202-8. doi: 10.1016/j.jconrel.2014.07.045. Epub 2014 Jul 29.


Actin limits enhancement of nanoparticle diffusion through cystic fibrosis sputum by mucolytics.

Broughton-Head VJ, Smith JR, Shur J, Shute JK.

Pulm Pharmacol Ther. 2007;20(6):708-17. Epub 2006 Sep 9.


Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport.

Dawson M, Wirtz D, Hanes J.

J Biol Chem. 2003 Dec 12;278(50):50393-401. Epub 2003 Sep 17.


Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus.

Lai SK, Suk JS, Pace A, Wang YY, Yang M, Mert O, Chen J, Kim J, Hanes J.

Biomaterials. 2011 Sep;32(26):6285-90. doi: 10.1016/j.biomaterials.2011.05.008. Epub 2011 Jun 12.


Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus.

Lai SK, O'Hanlon DE, Harrold S, Man ST, Wang YY, Cone R, Hanes J.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1482-7. Epub 2007 Jan 23.


Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy.

Forier K, Messiaen AS, Raemdonck K, Deschout H, Rejman J, De Baets F, Nelis H, De Smedt SC, Demeester J, Coenye T, Braeckmans K.

Nanomedicine (Lond). 2013 Jun;8(6):935-49. doi: 10.2217/nnm.12.129. Epub 2012 Oct 5.


Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus.

Henry CE, Wang YY, Yang Q, Hoang T, Chattopadhyay S, Hoen T, Ensign LM, Nunn KL, Schroeder H, McCallen J, Moench T, Cone R, Roffler SR, Lai SK.

Acta Biomater. 2016 Oct 1;43:61-70. doi: 10.1016/j.actbio.2016.07.019. Epub 2016 Jul 14.


Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors.

Schuster BS, Kim AJ, Kays JC, Kanzawa MM, Guggino WB, Boyle MP, Rowe SM, Muzyczka N, Suk JS, Hanes J.

Mol Ther. 2014 Aug;22(8):1484-1493. doi: 10.1038/mt.2014.89. Epub 2014 May 29.


Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier.

Suk JS, Kim AJ, Trehan K, Schneider CS, Cebotaru L, Woodward OM, Boylan NJ, Boyle MP, Lai SK, Guggino WB, Hanes J.

J Control Release. 2014 Mar 28;178:8-17. doi: 10.1016/j.jconrel.2014.01.007. Epub 2014 Jan 14.


Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation.

Boylan NJ, Suk JS, Lai SK, Jelinek R, Boyle MP, Cooper MJ, Hanes J.

J Control Release. 2012 Jan 10;157(1):72-9. doi: 10.1016/j.jconrel.2011.08.031. Epub 2011 Aug 31.


Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine.

De Lisle RC, Roach E, Jansson K.

Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G577-84. Epub 2007 Jul 5.


Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure.

Wang YY, Lai SK, So C, Schneider C, Cone R, Hanes J.

PLoS One. 2011;6(6):e21547. doi: 10.1371/journal.pone.0021547. Epub 2011 Jun 29.


Nanoparticle diffusion in respiratory mucus from humans without lung disease.

Schuster BS, Suk JS, Woodworth GF, Hanes J.

Biomaterials. 2013 Apr;34(13):3439-46. doi: 10.1016/j.biomaterials.2013.01.064. Epub 2013 Feb 4.


A strategy to deliver genes to cystic fibrosis lungs: a battle with environment.

Ibrahim BM, Park S, Han B, Yeo Y.

J Control Release. 2011 Oct 30;155(2):289-95. doi: 10.1016/j.jconrel.2011.07.039. Epub 2011 Aug 6.


A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue.

Nance EA, Woodworth GF, Sailor KA, Shih TY, Xu Q, Swaminathan G, Xiang D, Eberhart C, Hanes J.

Sci Transl Med. 2012 Aug 29;4(149):149ra119. doi: 10.1126/scitranslmed.3003594.

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