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T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis.

Angus-Hill ML, Elbert KM, Hidalgo J, Capecchi MR.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4914-9. doi: 10.1073/pnas.1102300108. Epub 2011 Mar 7.


Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine.

Fujisawa T, Sugiyama M, Tomimoto A, Wada K, Endo H, Takahashi H, Yoneda K, Yoneda M, Inamori M, Saito S, Terauchi Y, Kadowaki T, Tsuchiya N, Nakagama H, Nakajima A.

J Pharmacol Sci. 2008 Dec;108(4):535-44. Epub 2008 Dec 10.


GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.

Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT.

PLoS One. 2013 Jul 1;8(7):e67694. doi: 10.1371/journal.pone.0067694. Print 2013.


ITF2 prevents activation of the β-catenin-TCF4 complex in colon cancer cells and levels decrease with tumor progression.

Shin HW, Choi H, So D, Kim YI, Cho K, Chung HJ, Lee KH, Chun YS, Cho CH, Kang GH, Kim WH, Park JW.

Gastroenterology. 2014 Aug;147(2):430-442.e8. doi: 10.1053/j.gastro.2014.04.047. Epub 2014 May 15.


The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer.

Bush BM, Brock AT, Deng JA, Nelson RA, Sumter TF.

Cell Biochem Funct. 2013 Apr;31(3):228-36. doi: 10.1002/cbf.2876. Epub 2012 Sep 7.


Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression.

Wallmen B, Schrempp M, Hecht A.

Nucleic Acids Res. 2012 Oct;40(19):9455-69. doi: 10.1093/nar/gks690. Epub 2012 Aug 2.


VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.

Meyer MB, Goetsch PD, Pike JW.

Mol Endocrinol. 2012 Jan;26(1):37-51. doi: 10.1210/me.2011-1109. Epub 2011 Nov 22.


β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells.

Dentice M, Luongo C, Ambrosio R, Sibilio A, Casillo A, Iaccarino A, Troncone G, Fenzi G, Larsen PR, Salvatore D.

Gastroenterology. 2012 Oct;143(4):1037-47. doi: 10.1053/j.gastro.2012.06.042. Epub 2012 Jul 3.


Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway.

Sakamaki A, Katsuragi Y, Otsuka K, Tomita M, Obata M, Iwasaki T, Abe M, Sato T, Ochiai M, Sakuraba Y, Aoyagi Y, Gondo Y, Sakimura K, Nakagama H, Mishima Y, Kominami R.

Carcinogenesis. 2015 Jun;36(6):622-31. doi: 10.1093/carcin/bgv044. Epub 2015 Mar 31.


NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer.

Guo Q, Shen S, Liao M, Lian P, Wang X.

Acta Biochim Biophys Sin (Shanghai). 2010 Jul;42(7):450-6. doi: 10.1093/abbs/gmq049. Epub 2010 Jun 13.


Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling.

Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B, Tong XJ, Xie D.

J Biol Chem. 2007 Dec 14;282(50):36571-81. Epub 2007 Oct 21.


Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.

Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, Feinstein E, Einat P, Ben-Ze'ev A.

Genes Dev. 2002 Aug 15;16(16):2058-72.


Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells.

Hsu HH, Cheng SF, Chen LM, Liu JY, Chu CH, Weng YJ, Li ZY, Lin CS, Lee SD, Kuo WW, Huang CY.

Mol Cell Biochem. 2006 Sep;289(1-2):101-9. Epub 2006 Apr 21.


HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation.

Jung C, Kim RS, Zhang H, Lee SJ, Sheng H, Loehrer PJ, Gardner TA, Jeng MH, Kao C.

Br J Cancer. 2005 Jun 20;92(12):2233-9.


The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors.

Crawford HC, Fingleton B, Gustavson MD, Kurpios N, Wagenaar RA, Hassell JA, Matrisian LM.

Mol Cell Biol. 2001 Feb;21(4):1370-83.


Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway.

Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS.

J Pharmacol Sci. 2008 Apr;106(4):627-38. Epub 2008 Apr 5.


The Yin-Yang of TCF/beta-catenin signaling.

Barker N, Morin PJ, Clevers H.

Adv Cancer Res. 2000;77:1-24. Review.


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