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BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

Wiggins CM, Tsvetkov P, Johnson M, Joyce CL, Lamb CA, Bryant NJ, Komander D, Shaul Y, Cook SJ.

J Cell Sci. 2011 Mar 15;124(Pt 6):969-77. doi: 10.1242/jcs.058438.


Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM.

Wiggins CM, Johnson M, Cook SJ.

Cell Signal. 2010 May;22(5):801-8. doi: 10.1016/j.cellsig.2010.01.004. Epub 2010 Jan 13.


c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

Wiggins CM, Band H, Cook SJ.

Cell Signal. 2007 Dec;19(12):2605-11. Epub 2007 Aug 23.


ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.

Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ.

EMBO J. 2007 Jun 20;26(12):2856-67. Epub 2007 May 24.


CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.

Gilley R, Lochhead PA, Balmanno K, Oxley D, Clark J, Cook SJ.

Cell Signal. 2012 Jan;24(1):170-80. doi: 10.1016/j.cellsig.2011.08.018. Epub 2011 Sep 8.


Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons.

Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP.

J Biol Chem. 2006 Mar 17;281(11):7429-36. Epub 2006 Jan 23.


Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P.

Oncogene. 2003 Oct 2;22(43):6785-93.


Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

Thompson S, Pearson AN, Ashley MD, Jessick V, Murphy BM, Gafken P, Henshall DC, Morris KT, Simon RP, Meller R.

J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.


Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.

Qi XJ, Wildey GM, Howe PH.

J Biol Chem. 2006 Jan 13;281(2):813-23. Epub 2005 Nov 10.


Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.

Clybouw C, Merino D, Nebl T, Masson F, Robati M, O'Reilly L, Hübner A, Davis RJ, Strasser A, Bouillet P.

Cell Death Differ. 2012 Jun;19(6):1060-8. doi: 10.1038/cdd.2011.198. Epub 2012 Jan 13.


Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover.

Ley R, Ewings KE, Hadfield K, Howes E, Balmanno K, Cook SJ.

J Biol Chem. 2004 Mar 5;279(10):8837-47. Epub 2003 Dec 17.


Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels.

Ewings KE, Wiggins CM, Cook SJ.

Cell Cycle. 2007 Sep 15;6(18):2236-40. Epub 2007 Jul 10. Review.


Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways.

Weston CR, Balmanno K, Chalmers C, Hadfield K, Molton SA, Ley R, Wagner EF, Cook SJ.

Oncogene. 2003 Mar 6;22(9):1281-93.


Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.

Wickenden JA, Jin H, Johnson M, Gillings AS, Newson C, Austin M, Chell SD, Balmanno K, Pritchard CA, Cook SJ.

Oncogene. 2008 Dec 4;27(57):7150-61. doi: 10.1038/onc.2008.335. Epub 2008 Sep 22.


Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ.

J Biol Chem. 2003 May 23;278(21):18811-6. Epub 2003 Mar 19.


Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells.

Iglesias-Serret D, de Frias M, Santidrián AF, Coll-Mulet L, Cosialls AM, Barragán M, Domingo A, Gil J, Pons G.

Leukemia. 2007 Feb;21(2):281-7. Epub 2006 Dec 7.


Reciprocal protection of Mcl-1 and Bim from ubiquitin-proteasome degradation.

Wuillème-Toumi S, Trichet V, Gomez-Bougie P, Gratas C, Bataille R, Amiot M.

Biochem Biophys Res Commun. 2007 Oct 5;361(4):865-9. Epub 2007 Jul 24.


Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.

Wakeyama H, Akiyama T, Takahashi K, Amano H, Kadono Y, Nakamura M, Oshima Y, Itabe H, Nakayama KI, Nakayama K, Nakamura K, Tanaka S.

J Bone Miner Res. 2007 Oct;22(10):1631-9.

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