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Items: 1 to 20 of 116

1.

NMR-based metabolomics of mammalian cell and tissue cultures.

Aranibar N, Borys M, Mackin NA, Ly V, Abu-Absi N, Abu-Absi S, Niemitz M, Schilling B, Li ZJ, Brock B, Russell RJ 2nd, Tymiak A, Reily MD.

J Biomol NMR. 2011 Apr;49(3-4):195-206. doi: 10.1007/s10858-011-9490-8. Epub 2011 Mar 4.

PMID:
21373840
2.

Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture.

Chong WP, Goh LT, Reddy SG, Yusufi FN, Lee DY, Wong NS, Heng CK, Yap MG, Ho YS.

Rapid Commun Mass Spectrom. 2009 Dec;23(23):3763-71. doi: 10.1002/rcm.4328.

PMID:
19902412
3.

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism.

Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S.

Biotechnol Prog. 2009 Sep-Oct;25(5):1353-63. doi: 10.1002/btpr.238.

PMID:
19637321
4.

Metabolic analysis of antibody producing CHO cells in fed-batch production.

Dean J, Reddy P.

Biotechnol Bioeng. 2013 Jun;110(6):1735-47. doi: 10.1002/bit.24826. Epub 2013 Feb 15.

PMID:
23296898
5.

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media.

Chong WP, Yusufi FN, Lee DY, Reddy SG, Wong NS, Heng CK, Yap MG, Ho YS.

J Biotechnol. 2011 Jan 20;151(2):218-24. doi: 10.1016/j.jbiotec.2010.12.010. Epub 2010 Dec 16.

PMID:
21167884
6.

An omics approach to rational feed: Enhancing growth in CHO cultures with NMR metabolomics and 2D-DIGE proteomics.

Blondeel EJ, Ho R, Schulze S, Sokolenko S, Guillemette SR, Slivac I, Durocher Y, Guillemette JG, McConkey BJ, Chang D, Aucoin MG.

J Biotechnol. 2016 Sep 20;234:127-38. doi: 10.1016/j.jbiotec.2016.07.027. Epub 2016 Aug 2.

PMID:
27496566
7.

Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism.

Jeong DW, Cho IT, Kim TS, Bae GW, Kim IH, Kim IY.

Mol Cell Biochem. 2006 Mar;284(1-2):1-8. Epub 2006 Feb 14.

PMID:
16477389
8.

LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.

Chong WP, Thng SH, Hiu AP, Lee DY, Chan EC, Ho YS.

Biotechnol Bioeng. 2012 Dec;109(12):3103-11. doi: 10.1002/bit.24580. Epub 2012 Jul 4.

PMID:
22711553
9.

Metabolic profiling studies on the toxicological effects of realgar in rats by (1)H NMR spectroscopy.

Wei L, Liao P, Wu H, Li X, Pei F, Li W, Wu Y.

Toxicol Appl Pharmacol. 2009 Feb 1;234(3):314-25. doi: 10.1016/j.taap.2008.11.010. Epub 2008 Nov 25.

PMID:
19073202
10.

Fermentanomics: monitoring mammalian cell cultures with NMR spectroscopy.

Bradley SA, Ouyang A, Purdie J, Smitka TA, Wang T, Kaerner A.

J Am Chem Soc. 2010 Jul 21;132(28):9531-3. doi: 10.1021/ja101962c.

PMID:
20578691
11.

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture.

Selvarasu S, Ho YS, Chong WP, Wong NS, Yusufi FN, Lee YY, Yap MG, Lee DY.

Biotechnol Bioeng. 2012 Jun;109(6):1415-29. doi: 10.1002/bit.24445. Epub 2012 Jan 31.

PMID:
22252269
12.

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

Atherton HJ, Bailey NJ, Zhang W, Taylor J, Major H, Shockcor J, Clarke K, Griffin JL.

Physiol Genomics. 2006 Oct 11;27(2):178-86. Epub 2006 Jul 25.

13.

Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR.

Baverel G, Renault S, Faiz H, El Hage M, Gauthier C, Duplany A, Ferrier B, Martin G.

Methods Mol Biol. 2011;691:205-25. doi: 10.1007/978-1-60761-849-2_12.

PMID:
20972755
14.

Toward Arabidopsis thaliana hydrophilic metabolome: assessment of extraction methods and quantitative 1H NMR.

Gromova M, Roby C.

Physiol Plant. 2010 Oct;140(2):111-27. doi: 10.1111/j.1399-3054.2010.01387.x.

PMID:
20522173
15.

Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy.

Goudar C, Biener R, Boisart C, Heidemann R, Piret J, de Graaf A, Konstantinov K.

Metab Eng. 2010 Mar;12(2):138-49. doi: 10.1016/j.ymben.2009.10.007. Epub 2009 Nov 5.

PMID:
19896555
16.

A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures.

Figueroa B Jr, Sauerwald TM, Oyler GA, Hardwick JM, Betenbaugh MJ.

Metab Eng. 2003 Oct;5(4):230-45.

PMID:
14642351
17.

Changes in the metabolic profile of rat liver after α-tocopherol deficiency as revealed by metabolomics analysis.

Moazzami AA, Andersson R, Kamal-Eldin A.

NMR Biomed. 2011 Jun;24(5):499-505. doi: 10.1002/nbm.1615. Epub 2010 Nov 30.

PMID:
21674651
18.

NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration.

Bu Q, Yan G, Deng P, Peng F, Lin H, Xu Y, Cao Z, Zhou T, Xue A, Wang Y, Cen X, Zhao YL.

Nanotechnology. 2010 Mar 26;21(12):125105. doi: 10.1088/0957-4484/21/12/125105. Epub 2010 Mar 5.

PMID:
20203358
19.

Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization.

Seli E, Botros L, Sakkas D, Burns DH.

Fertil Steril. 2008 Dec;90(6):2183-9. doi: 10.1016/j.fertnstert.2008.07.1739. Epub 2008 Oct 8.

PMID:
18842260
20.

¹H NMR spectroscopy profiling of metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture.

Wagstaff JL, Masterton RJ, Povey JF, Smales CM, Howard MJ.

PLoS One. 2013 Oct 10;8(10):e77195. doi: 10.1371/journal.pone.0077195. eCollection 2013.

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