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Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.

Kaur S, Kuznetsova SA, Pendrak ML, Sipes JM, Romeo MJ, Li Z, Zhang L, Roberts DD.

J Biol Chem. 2011 Apr 29;286(17):14991-5002. doi: 10.1074/jbc.M110.179663. Epub 2011 Feb 22.


Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation.

Miller TW, Kaur S, Ivins-O'Keefe K, Roberts DD.

Matrix Biol. 2013 Aug 8;32(6):316-24. doi: 10.1016/j.matbio.2013.02.009. Epub 2013 Mar 13.


Thrombospondin-1 inhibits TCR-mediated T lymphocyte early activation.

Li Z, He L, Wilson K, Roberts D.

J Immunol. 2001 Feb 15;166(4):2427-36.


CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1.

Isenberg JS, Ridnour LA, Dimitry J, Frazier WA, Wink DA, Roberts DD.

J Biol Chem. 2006 Sep 8;281(36):26069-80. Epub 2006 Jul 11.


CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells.

Kaur S, Singh SP, Elkahloun AG, Wu W, Abu-Asab MS, Roberts DD.

Matrix Biol. 2014 Jul;37:49-59. doi: 10.1016/j.matbio.2014.05.007. Epub 2014 Jun 2.


Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.

Isenberg JS, Frazier WA, Krishna MC, Wink DA, Roberts DD.

Curr Drug Targets. 2008 Oct;9(10):833-41. Review.


CD47 signaling regulates the immunosuppressive activity of VEGF in T cells.

Kaur S, Chang T, Singh SP, Lim L, Mannan P, Garfield SH, Pendrak ML, Soto-Pantoja DR, Rosenberg AZ, Jin S, Roberts DD.

J Immunol. 2014 Oct 15;193(8):3914-24. doi: 10.4049/jimmunol.1303116. Epub 2014 Sep 8.


Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior.

Li Z, Calzada MJ, Sipes JM, Cashel JA, Krutzsch HC, Annis DS, Mosher DF, Roberts DD.

J Cell Biol. 2002 Apr 29;157(3):509-19. Epub 2002 Apr 29.


Perlecan is responsible for thrombospondin 1 binding on the cell surface of cultured porcine endothelial cells.

Vischer P, Feitsma K, Schön P, Völker W.

Eur J Cell Biol. 1997 Aug;73(4):332-43.


Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.

Kaur S, Martin-Manso G, Pendrak ML, Garfield SH, Isenberg JS, Roberts DD.

J Biol Chem. 2010 Dec 10;285(50):38923-32. doi: 10.1074/jbc.M110.172304. Epub 2010 Oct 5.


Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion.

Barazi HO, Li Z, Cashel JA, Krutzsch HC, Annis DS, Mosher DF, Roberts DD.

J Biol Chem. 2002 Nov 8;277(45):42859-66. Epub 2002 Sep 5.


Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors.

Kaur S, Soto-Pantoja DR, Stein EV, Liu C, Elkahloun AG, Pendrak ML, Nicolae A, Singh SP, Nie Z, Levens D, Isenberg JS, Roberts DD.

Sci Rep. 2013;3:1673. doi: 10.1038/srep01673.


The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.

Roberts DD, Miller TW, Rogers NM, Yao M, Isenberg JS.

Matrix Biol. 2012 Apr;31(3):162-9. doi: 10.1016/j.matbio.2012.01.005. Epub 2012 Jan 14. Review.


Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide.

Buée L, Ding W, Anderson JP, Narindrasorasak S, Kisilevsky R, Boyle NJ, Robakis NK, Delacourte A, Greenberg B, Fillit HM.

Brain Res. 1993 Nov 12;627(2):199-204.


Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47.

Stein EV, Miller TW, Ivins-O'Keefe K, Kaur S, Roberts DD.

Sci Rep. 2016 Jan 27;6:19684. doi: 10.1038/srep19684.


Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress.

Isenberg JS, Qin Y, Maxhimer JB, Sipes JM, Despres D, Schnermann J, Frazier WA, Roberts DD.

Matrix Biol. 2009 Mar;28(2):110-9. doi: 10.1016/j.matbio.2009.01.002. Epub 2009 Jan 21.


Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

Isenberg JS, Annis DS, Pendrak ML, Ptaszynska M, Frazier WA, Mosher DF, Roberts DD.

J Biol Chem. 2009 Jan 9;284(2):1116-25. doi: 10.1074/jbc.M804860200. Epub 2008 Nov 11.


An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs.

McDonald JF, Dimitry JM, Frazier WA.

Biochemistry. 2003 Aug 26;42(33):10001-11.


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