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β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway.

Qian L, Wu HM, Chen SH, Zhang D, Ali SF, Peterson L, Wilson B, Lu RB, Hong JS, Flood PM.

J Immunol. 2011 Apr 1;186(7):4443-54. doi: 10.4049/jimmunol.1002449.


Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity.

Zhang D, Hu X, Wei SJ, Liu J, Gao H, Qian L, Wilson B, Liu G, Hong JS.

J Neuroinflammation. 2008 May 28;5:21. doi: 10.1186/1742-2094-5-21.


beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway.

Qian L, Hu X, Zhang D, Snyder A, Wu HM, Li Y, Wilson B, Lu RB, Hong JS, Flood PM.

Glia. 2009 Nov 15;57(15):1600-9. doi: 10.1002/glia.20873.


3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity.

Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS.

FASEB J. 2005 Mar;19(3):395-7.


Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS.

J Pharmacol Exp Ther. 2003 Apr;305(1):212-8.


Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.

Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM.

Mol Pharmacol. 2010 Sep;78(3):466-77. doi: 10.1124/mol.110.064535. Erratum in: Mol Pharmacol. 2010 Nov;78(5):981.


Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation.

Hu X, Zhou H, Zhang D, Yang S, Qian L, Wu HM, Chen PS, Wilson B, Gao HM, Lu RB, Hong JS.

J Neuroimmune Pharmacol. 2012 Mar;7(1):187-201. doi: 10.1007/s11481-011-9309-0.


Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation.

Liu Y, Lo YC, Qian L, Crews FT, Wilson B, Chen HL, Wu HM, Chen SH, Wei K, Lu RB, Ali S, Hong JS.

Neuropharmacology. 2011 Feb-Mar;60(2-3):373-80. doi: 10.1016/j.neuropharm.2010.10.002.


Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity.

Qian L, Tan KS, Wei SJ, Wu HM, Xu Z, Wilson B, Lu RB, Hong JS, Flood PM.

J Immunol. 2007 Jul 15;179(2):1198-209.


The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.

Tran TA, McCoy MK, Sporn MB, Tansey MG.

J Neuroinflammation. 2008 May 12;5:14. doi: 10.1186/1742-2094-5-14.


A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis.

Jiang L, Chen SH, Chu CH, Wang SJ, Oyarzabal E, Wilson B, Sanders V, Xie K, Wang Q, Hong JS.

Glia. 2015 Jun;63(6):1057-72. doi: 10.1002/glia.22801.


Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation.

Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, Hong JS, Jeng KC.

Eur J Neurosci. 2002 Dec;16(11):2103-12.


Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson's disease.

Wang S, Jing H, Yang H, Liu Z, Guo H, Chai L, Hu L.

J Ethnopharmacol. 2015 Apr 22;164:247-55. doi: 10.1016/j.jep.2015.01.042.


Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways.

Wang X, Wang C, Wang J, Zhao S, Zhang K, Wang J, Zhang W, Wu C, Yang J.

Neuropharmacology. 2014 Apr;79:642-56. doi: 10.1016/j.neuropharm.2014.01.022.


Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity.

Zhang F, Qian L, Flood PM, Shi JS, Hong JS, Gao HM.

J Pharmacol Exp Ther. 2010 Jun;333(3):822-33. doi: 10.1124/jpet.110.165829.


Fluoxetine protects neurons against microglial activation-mediated neurotoxicity.

Zhang F, Zhou H, Wilson BC, Shi JS, Hong JS, Gao HM.

Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S213-7. doi: 10.1016/S1353-8020(11)70066-9.


Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.

Yang S, Yang J, Yang Z, Chen P, Fraser A, Zhang W, Pang H, Gao X, Wilson B, Hong JS, Block ML.

J Pharmacol Exp Ther. 2006 Nov;319(2):595-603.


Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms.

Fu SP, Wang JF, Xue WJ, Liu HM, Liu BR, Zeng YL, Li SN, Huang BX, Lv QK, Wang W, Liu JX.

J Neuroinflammation. 2015 Jan 17;12:9. doi: 10.1186/s12974-014-0230-3.


Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation.

Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park S.

Neurotox Res. 2009 May;15(4):332-47. doi: 10.1007/s12640-009-9037-x.

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