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Items: 1 to 20 of 152

1.

Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

Mol Biosyst. 2011 May;7(5):1409-19. doi: 10.1039/c0mb00309c. Epub 2011 Feb 16.

PMID:
21327189
2.

Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

J Biol Chem. 2009 Nov 27;284(48):33425-36. doi: 10.1074/jbc.M109.049478. Epub 2009 Sep 16.

3.

Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.

Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD.

Metabolism. 2014 Feb;63(2):283-95. doi: 10.1016/j.metabol.2013.10.009. Epub 2013 Oct 24.

4.

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, Kinoshita T, Saito N, Ochiai A, Tomita M, Esumi H, Soga T.

Cancer Res. 2009 Jun 1;69(11):4918-25. doi: 10.1158/0008-5472.CAN-08-4806. Epub 2009 May 19.

5.

Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose.

Miwa H, Shikami M, Goto M, Mizuno S, Takahashi M, Tsunekawa-Imai N, Ishikawa T, Mizutani M, Horio T, Gotou M, Yamamoto H, Wakabayashi M, Watarai M, Hanamura I, Imamura A, Mihara H, Nitta M.

Oncol Rep. 2013 May;29(5):2053-7. doi: 10.3892/or.2013.2299. Epub 2013 Feb 21.

PMID:
23440281
6.

Metabolomic and transcriptomic profiling of hepatocellular carcinomas in Hras12V transgenic mice.

Fan T, Rong Z, Dong J, Li J, Wang K, Wang X, Li H, Chen J, Wang F, Wang J, Wang A.

Cancer Med. 2017 Oct;6(10):2370-2384. doi: 10.1002/cam4.1177. Epub 2017 Sep 21.

7.

Cross-platform comparison of methods for quantitative metabolomics of primary metabolism.

Büscher JM, Czernik D, Ewald JC, Sauer U, Zamboni N.

Anal Chem. 2009 Mar 15;81(6):2135-43. doi: 10.1021/ac8022857.

PMID:
19236023
8.

Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death.

Choi SE, Lee YJ, Hwang GS, Chung JH, Lee SJ, Lee JH, Han SJ, Kim HJ, Lee KW, Kim Y, Jun HS, Kang Y.

Arch Biochem Biophys. 2011 Jan 15;505(2):231-41. doi: 10.1016/j.abb.2010.10.011. Epub 2010 Oct 18.

PMID:
20965146
9.

Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death.

Uen YH, Ko PH, Yin PH, Liu TY, Chi CW, Lui WY.

Int J Oncol. 2008 Dec;33(6):1263-70.

PMID:
19020760
10.

Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling.

Liu Y, Lu S, Zhao L, Dong X, Zhu Z, Jin Y, Chen H, Lu F, Hong Z, Chai Y.

Anal Bioanal Chem. 2018 May;410(14):3325-3335. doi: 10.1007/s00216-018-0996-8. Epub 2018 Apr 13.

PMID:
29651531
11.

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H, Miyamoto K, Kaneko S.

J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.

12.

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.

Tan B, Young DA, Lu ZH, Wang T, Meier TI, Shepard RL, Roth K, Zhai Y, Huss K, Kuo MS, Gillig J, Parthasarathy S, Burkholder TP, Smith MC, Geeganage S, Zhao G.

J Biol Chem. 2013 Feb 1;288(5):3500-11. doi: 10.1074/jbc.M112.394510. Epub 2012 Dec 13.

13.

A human hepatocellular in vitro model to investigate steatosis.

Gómez-Lechón MJ, Donato MT, Martínez-Romero A, Jiménez N, Castell JV, O'Connor JE.

Chem Biol Interact. 2007 Jan 30;165(2):106-16. Epub 2006 Nov 23.

PMID:
17188672
14.

Influences of methamphetamine-induced acute intoxication on urinary and plasma metabolic profiles in the rat.

Shima N, Miyawaki I, Bando K, Horie H, Zaitsu K, Katagi M, Bamba T, Tsuchihashi H, Fukusaki E.

Toxicology. 2011 Sep 5;287(1-3):29-37. doi: 10.1016/j.tox.2011.05.012. Epub 2011 May 27.

PMID:
21645582
15.

GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats.

Bando K, Kunimatsu T, Sakai J, Kimura J, Funabashi H, Seki T, Bamba T, Fukusaki E.

J Appl Toxicol. 2011 Aug;31(6):524-35. doi: 10.1002/jat.1591. Epub 2010 Dec 10.

PMID:
21154879
16.
17.

Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics.

Huang Q, Tan Y, Yin P, Ye G, Gao P, Lu X, Wang H, Xu G.

Cancer Res. 2013 Aug 15;73(16):4992-5002. doi: 10.1158/0008-5472.CAN-13-0308. Epub 2013 Jul 1.

18.

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells.

Tolstikov V, Nikolayev A, Dong S, Zhao G, Kuo MS.

PLoS One. 2014 Dec 8;9(12):e114019. doi: 10.1371/journal.pone.0114019. eCollection 2014.

19.

Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.

Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, Pibiri M.

Apoptosis. 2007 Jan;12(1):113-23.

PMID:
17136495
20.

Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.

Chen CY, Liu TZ, Chen CH, Wu CC, Cheng JT, Yiin SJ, Shih MK, Wu MJ, Chern CL.

Food Chem Toxicol. 2007 Jul;45(7):1268-76. Epub 2007 Jan 20.

PMID:
17321026

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