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Items: 1 to 20 of 212


Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic.

Plemel RL, Lobingier BT, Brett CL, Angers CG, Nickerson DP, Paulsel A, Sprague D, Merz AJ.

Mol Biol Cell. 2011 Apr 15;22(8):1353-63. doi: 10.1091/mbc.E10-03-0260. Epub 2011 Feb 16.


The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.

Markgraf DF, Ahnert F, Arlt H, Mari M, Peplowska K, Epp N, Griffith J, Reggiori F, Ungermann C.

Mol Biol Cell. 2009 Dec;20(24):5276-89. doi: 10.1091/mbc.E09-06-0521.


Defined subunit arrangement and rab interactions are required for functionality of the HOPS tethering complex.

Ostrowicz CW, Bröcker C, Ahnert F, Nordmann M, Lachmann J, Peplowska K, Perz A, Auffarth K, Engelbrecht-Vandré S, Ungermann C.

Traffic. 2010 Oct;11(10):1334-46. doi: 10.1111/j.1600-0854.2010.01097.x.


The N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.

Epp N, Ungermann C.

PLoS One. 2013 Jun 20;8(6):e67307. doi: 10.1371/journal.pone.0067307. Print 2013.


The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.

Peplowska K, Markgraf DF, Ostrowicz CW, Bange G, Ungermann C.

Dev Cell. 2007 May;12(5):739-50.


The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.

Balderhaar HJ, Lachmann J, Yavavli E, Bröcker C, Lürick A, Ungermann C.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3823-8. doi: 10.1073/pnas.1221785110. Epub 2013 Feb 15.


Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.

Brett CL, Plemel RL, Lobingier BT, Vignali M, Fields S, Merz AJ.

J Cell Biol. 2008 Sep 22;182(6):1141-51. doi: 10.1083/jcb.200801001. Erratum in: J Cell Biol. 2011 Dec 12;195(6):1061. Lobinger, Braden T [corrected to Lobingier, Braden T].


Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking.

Pawelec A, Arsić J, Kölling R.

Eukaryot Cell. 2010 Apr;9(4):602-10. doi: 10.1128/EC.00286-09. Epub 2010 Feb 19.


Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis.

Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, Reggiori F, Ungermann C.

J Biol Chem. 2013 Feb 15;288(7):5166-75. doi: 10.1074/jbc.M112.431536. Epub 2012 Dec 21.


The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.

Nordmann M, Cabrera M, Perz A, Bröcker C, Ostrowicz C, Engelbrecht-Vandré S, Ungermann C.

Curr Biol. 2010 Sep 28;20(18):1654-9. doi: 10.1016/j.cub.2010.08.002.


Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites.

Cabrera M, Ostrowicz CW, Mari M, LaGrassa TJ, Reggiori F, Ungermann C.

Mol Biol Cell. 2009 Apr;20(7):1937-48. doi: 10.1091/mbc.E08-09-0943. Epub 2009 Feb 4.


Rab GTPase regulation of retromer-mediated cargo export during endosome maturation.

Liu TT, Gomez TS, Sackey BK, Billadeau DD, Burd CG.

Mol Biol Cell. 2012 Jul;23(13):2505-15. doi: 10.1091/mbc.E11-11-0915. Epub 2012 May 16.


Vps-C complexes: gatekeepers of endolysosomal traffic.

Nickerson DP, Brett CL, Merz AJ.

Curr Opin Cell Biol. 2009 Aug;21(4):543-51. doi: 10.1016/ Epub 2009 Jul 3. Review.


The HOPS/class C Vps complex tethers membranes by binding to one Rab GTPase in each apposed membrane.

Ho R, Stroupe C.

Mol Biol Cell. 2015 Jul 15;26(14):2655-63. doi: 10.1091/mbc.E14-04-0922. Epub 2015 May 20.


The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles.

Lachmann J, Barr FA, Ungermann C.

Mol Biol Cell. 2012 Jul;23(13):2516-26. doi: 10.1091/mbc.E11-12-1030. Epub 2012 May 16.


Tethering complexes in the endocytic pathway: CORVET and HOPS.

Solinger JA, Spang A.

FEBS J. 2013 Jun;280(12):2743-57. doi: 10.1111/febs.12151. Epub 2013 Feb 21. Review.


Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs.

Epp N, Rethmeier R, Krämer L, Ungermann C.

Eur J Cell Biol. 2011 Sep;90(9):779-85. doi: 10.1016/j.ejcb.2011.04.007. Epub 2011 Jun 16. Review.


Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.

Zlatic SA, Tornieri K, L'Hernault SW, Faundez V.

Mol Biol Cell. 2011 May 15;22(10):1699-715. doi: 10.1091/mbc.E10-10-0799. Epub 2011 Mar 16.


Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole.

Rana M, Lachmann J, Ungermann C.

Mol Biol Cell. 2015 Jul 1;26(13):2535-49. doi: 10.1091/mbc.E15-02-0062. Epub 2015 May 13.

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