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21323995,25819185,23812184,27989054,19021976,27209111,28846524,25869085,28500139,27085434,22657269,26670058,26105038,23489531,28559420,22329976,27048774,25438916,22336754,23661722,24263007,26876419,25681417,19442886,23770162,16118072,27406843,18824760,25267695,25946444,25316349,25896358,27903539,25657315,28552098,24407885,22511546,23267804,28572283,22869821,25499832,27296201,25677424,24221391,11955855,28814490,20975002,17533183,22974713,28488096,25234675,21718826,26897807,23489257,21087751,21296330,25852129,33787311,23300268,26718321,22959323,32327100,31327014,32066613,21619977,18154789,22959325,24787695,33189205,29605969,29029001,23856202,24597400,24096324,30712486,29289632,16820634,23349350,25320140,25320287,24740834,18365573,29406851,32204665,28864136,21805576,29222121,22782969,28890466,19196573,22257710,26504147,29040507,23870156,22244555,27143354,21321152,25946438,29124471,24122890,19962482,21303867,23669595,24777938,22791205,24210335,24125091,24076528,16359056,26175530,31679642,27866867,21714418,16757422,25018158,30039338,27865193,19442889,28183438,25757476,26334242,16386914,27514931,21601829,22632826,28417865,26834233,22138006,31705575,19596667,25455463,30745019,23062481,27168140,31550970,29021260,28290165,29909108,24779322,26358259,26223986,29751954,28329360,23602168,24012027,27544900,33461302,30865913,26363832,24048203,25772832,28648391,31439661,25217490,29302940,33641670,24152252,30376590,32031603,33283639,25572511,30448114,28797414,27650723,35241220,24755006,28194496,29973671,26787441,29439881,33336497,23489526,28684442,23167221,28950336,29021259,26204677,21969256,23551697,26911132,22808831,27838305,32139161,32817269,31048555,26341121,27792655,21863651,34023890,26936469,32299587,28698585,35621198,23008423,26321001,30002099,25212548,28739863,32770378,23500295,25200726,27458659,23891429,26953820,21564277,26897816,29547988,24948491,23675682,32160622,27540178,31072724,24172078,27190103,25502166,29092919,25902905,28823481,35984497,31352636,28488404,35525841,30085068,34082909,24025956,22497679,28412115,31589485,34864942,37020291,33388447,26089012,22862297,32345658,31959010,34854128,35716947,32964785,31866321,24955041,32650909,24780909,15459762,35430696,31810475,24874975,28710181,24775615,26649912,32155164,12438294,29212513,25402513,26529082,26477634,28005568,31522771,1516206,28370476,30585157,28950322,34158367,29306545,30158400,21641359,26072911,30905426,28078606,28994654,35766279,33453161,30304720,32362405,26475710,30621989,30841771,23237930,33652083,26615522,11018209,32187352,35732565,26219495,27875347,26995381,31401051,22101151,24528173,12027130,28781116,33465798,30285058,31286414,24639092,33607944,28655164,29158019,31875594,31857020,27903371,12895611,26742587,27567134,31377777,25998445,29654094,29395002,23533186,31586530,29566814,33253813,24342305,23969478,28247566,35433871,36508765,28363204,31666577,27287062,31601929,33431618,29701384,22497825,24343152,24145591,23580789,25012059,28179592,32843207,12732811,34275976,28429500,25514504,25151288,34491310,24399781,11448410,35137010,26886708,12732816,33372529,27792660,21718827,32005565,34051288,22733832,23812183,34023273,10779461,36043300,11083674,24630788,34107986,31316039,32747121,36519605,30938881,27278911,19608291,29276909,34482711,33896873,16524534,31792637,25677425,34586336,26994155,29506780,30621991,23833296,32725989,37131301,36084744,34973961,18025609,22942293,29596567,28803987,6690545,34136710,22943332,31785953,21440885,30155884,23915521,32500142,21844086,21844085,34915134,12418948,22796812,29877303,25796400,26531820,34533650,31982104,30299294,27615013,37095171,34291701,35182257,25168095,32945926,36241571,27049682,30037422,22664178,35641101,32418453,28735253,29062743,36071759,30409026,35697496,23500296,28499670,11355138,33720639,36241549,34949582,25070557,22657267,35470234,25070556,29561987,34650372,16200265,16411151,27236112,30522658,34593341,25089307,27334030,26144870,21742465,24461481,24400204,30505491,24048202,25987267,28396860,31719000,36826534,33808189,32771585,8712130,1527905,21947941,36704453,12679224,21947940,37026360,1636603,33807143,35816480,26196018,33614743,23602166,33344514,27252876,36963660,34139187,33937694,27199070,26140146,27895025,23500224,32259845,35629075,15553297,2312955[uid]

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Outcomes and survival with aortic valve replacement compared with medical therapy in patients with low-, moderate-, and severe-gradient severe aortic stenosis and normal left ventricular ejection fraction.

Belkin RN, Khalique O, Aronow WS, Ahn C, Sharma M. Belkin RN, et al. Echocardiography. 2011 Apr;28(4):378-87. doi: 10.1111/j.1540-8175.2010.01372.x. Epub 2011 Feb 17. Echocardiography. 2011. PMID: 21323995

Tricuspid Regurgitation Is Associated With Increased Risk of Mortality in Patients With Low-Flow Low-Gradient Aortic Stenosis and Reduced Ejection Fraction: Results of the Multicenter TOPAS Study (True or Pseudo-Severe Aortic Stenosis).

Dahou A, Magne J, Clavel MA, Capoulade R, Bartko PE, Bergler-Klein J, Sénéchal M, Mundigler G, Burwash I, Ribeiro HB, O'Connor K, Mathieu P, Baumgartner H, Dumesnil JG, Rosenhek R, Larose E, Rodés-Cabau J, Pibarot P. Dahou A, et al. JACC Cardiovasc Interv. 2015 Apr 20;8(4):588-96. doi: 10.1016/j.jcin.2014.08.019. Epub 2015 Mar 26. JACC Cardiovasc Interv. 2015. PMID: 25819185 Free article.

Impact of aortic valve replacement on outcome of symptomatic patients with severe aortic stenosis with low gradient and preserved left ventricular ejection fraction.

Ozkan A, Hachamovitch R, Kapadia SR, Tuzcu EM, Marwick TH. Ozkan A, et al. Circulation. 2013 Aug 6;128(6):622-31. doi: 10.1161/CIRCULATIONAHA.112.001094. Epub 2013 Jun 27. Circulation. 2013. PMID: 23812184 Clinical Trial.

Contribution of Dobutamine Stress Echocardiography to the Diagnosis and Prognosis of Low-Flow/Low-Gradient Aortic Stenosis.

Aguiar Rosa S, Moura Branco L, Galrinho A, Portugal G, Abreu J, Cacela D, Fragata J, Cruz Ferreira R. Aguiar Rosa S, et al. J Heart Valve Dis. 2016 Mar;25(2):130-138. J Heart Valve Dis. 2016. PMID: 27989054

Survival benefit of aortic valve replacement in patients with severe aortic stenosis with low ejection fraction and low gradient with normal ejection fraction.

Pai RG, Varadarajan P, Razzouk A. Pai RG, et al. Ann Thorac Surg. 2008 Dec;86(6):1781-9. doi: 10.1016/j.athoracsur.2008.08.008. Ann Thorac Surg. 2008. PMID: 19021976

Discordant Grading of Aortic Stenosis Severity: Echocardiographic Predictors of Survival Benefit Associated With Aortic Valve Replacement.

Berthelot-Richer M, Pibarot P, Capoulade R, Dumesnil JG, Dahou A, Thebault C, Le Ven F, Clavel MA. Berthelot-Richer M, et al. JACC Cardiovasc Imaging. 2016 Jul;9(7):797-805. doi: 10.1016/j.jcmg.2015.09.026. Epub 2016 May 18. JACC Cardiovasc Imaging. 2016. PMID: 27209111 Free article.

Outcome of Patients with Low-Flow/Low-Gradient Severe Aortic Stenosis Who Underwent Aortic Valve Replacement.

Fan XL, Zhang J, Wang C, Chong H, Zhang G, Xue Q, Tang Y, Han L. Fan XL, et al. Heart Surg Forum. 2017 Jul 20;20(4):E124-E128. doi: 10.1532/hsf.1709. Heart Surg Forum. 2017. PMID: 28846524

Outcomes of surgical aortic valve replacement for severe aortic stenosis: Incorporation of left ventricular systolic function and stroke volume index.

Parikh R, Goodman AL, Barr T, Sabik JF, Svensson LG, Rodriguez LL, Lytle BW, Grimm RA, Griffin BP, Desai MY. Parikh R, et al. J Thorac Cardiovasc Surg. 2015 Jun;149(6):1558-66.e1. doi: 10.1016/j.jtcvs.2015.03.008. Epub 2015 Mar 11. J Thorac Cardiovasc Surg. 2015. PMID: 25869085 Free article.

High- Versus Low-Gradient Severe Aortic Stenosis: Demographics, Clinical Outcomes, and Effects of the Initial Aortic Valve Replacement Strategy on Long-Term Prognosis.

Taniguchi T, Morimoto T, Shiomi H, Ando K, Kanamori N, Murata K, Kitai T, Kawase Y, Izumi C, Miyake M, Mitsuoka H, Kato M, Hirano Y, Matsuda S, Inada T, Nagao K, Murakami T, Takeuchi Y, Yamane K, Toyofuku M, Ishii M, Minamino-Muta E, Kato T, Inoko M, Ikeda T, Komasa A, Ishii K, Hotta K, Higashitani N, Kato Y, Inuzuka Y, Maeda C, Jinnai T, Morikami Y, Saito N, Minatoya K, Kimura T; CURRENT AS Registry Investigators. Taniguchi T, et al. Circ Cardiovasc Interv. 2017 May;10(5):e004796. doi: 10.1161/CIRCINTERVENTIONS.116.004796. Circ Cardiovasc Interv. 2017. PMID: 28500139

Early Diastolic Strain Rate in Relation to Systolic and Diastolic Function and Prognosis in Aortic Stenosis.

Dahl JS, Barros-Gomes S, Videbæk L, Poulsen MK, Issa IF, Carter-Storch R, Christensen NL, Kumme A, Pellikka PA, Møller JE. Dahl JS, et al. JACC Cardiovasc Imaging. 2016 May;9(5):519-28. doi: 10.1016/j.jcmg.2015.06.029. Epub 2016 Apr 13. JACC Cardiovasc Imaging. 2016. PMID: 27085434 Free article. Clinical Trial.

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