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Items: 1 to 20 of 41

1.

Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators.

Lopez S, Margison GP, McElhinney RS, Cordeiro A, McMurry TB, Rozas I.

Bioorg Med Chem. 2011 Mar 1;19(5):1658-65. doi: 10.1016/j.bmc.2011.01.038. Epub 2011 Jan 27.

PMID:
21320783
3.

Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging.

Mühlhausen U, Schirrmacher R, Piel M, Lecher B, Briegert M, Piee-Staffa A, Kaina B, Rösch F.

J Med Chem. 2006 Jan 12;49(1):263-72.

PMID:
16392811
4.
5.

Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships.

Reinhard J, Hull WE, von der Lieth CW, Eichhorn U, Kliem HC, Kaina B, Wiessler M.

J Med Chem. 2001 Nov 22;44(24):4050-61.

PMID:
11708909
6.

Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations.

Kim JI, Suh JT, Choi KU, Kang HJ, Shin DH, Lee IS, Moon TY, Kim WT.

Hum Pathol. 2009 Jul;40(7):934-41. doi: 10.1016/j.humpath.2009.01.005. Epub 2009 Apr 7.

PMID:
19356788
7.

The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.

Hornillo-Araujo AR, Burrell AJ, Aiertza MK, Shibata T, Hammond DM, Edmont D, Adams H, Margison GP, Williams DM.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1099-102.

PMID:
18058544
9.

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.

Hazra TK, Roy R, Biswas T, Grabowski DT, Pegg AE, Mitra S.

Biochemistry. 1997 May 13;36(19):5769-76.

PMID:
9153417
10.

MGMT inhibitors--The Trinity College-Paterson Institute experience, a chemist's perception.

McMurry TB.

DNA Repair (Amst). 2007 Aug 1;6(8):1161-9. Epub 2007 May 7.

PMID:
17485250
11.

Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism.

Kokkinakis DM, Moschel RC, Vuong TH, Reddy MV, Schold SC, Pegg AE.

In Vivo. 1996 May-Jun;10(3):297-306.

PMID:
8797031
12.

Structure-based discovery of novel non-nucleosidic DNA alkyltransferase inhibitors: virtual screening and in vitro and in vivo activities.

Ruiz FM, Gil-Redondo R, Morreale A, Ortiz AR, Fábrega C, Bravo J.

J Chem Inf Model. 2008 Apr;48(4):844-54. doi: 10.1021/ci700447r. Epub 2008 Mar 20.

PMID:
18351730
13.

Repair of DNA lesion O6-methylguanine in hepatocellular carcinogenesis.

Major GN, Collier JD.

J Hepatobiliary Pancreat Surg. 1998;5(4):355-66. Review.

PMID:
9931384
14.
15.
16.

Understanding and manipulating O6-methylguanine-DNA methyltransferase expression.

Pieper RO.

Pharmacol Ther. 1997;74(3):285-97. Review.

PMID:
9352585
17.

Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

Jean-Claude BJ, Mustafa A, Watson AJ, Damian Z, Vasilescu D, Chan TH, Leyland-Jones B.

J Pharmacol Exp Ther. 1999 Feb;288(2):484-9.

PMID:
9918549
18.
19.

Novel post DNA synthesis chemistry for preparing oligonucleotides containing O6-modified purines.

Shibata T, Williams DM.

Nucleic Acids Symp Ser (Oxf). 2005;(49):23-4.

PMID:
17150614
20.

Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.

Ma LC, Kuo CC, Liu JF, Chen LT, Chang JY.

Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.

PMID:
18492797

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