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Items: 1 to 20 of 102

1.

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.

Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X.

Pain. 2011 Apr;152(4):878-87. doi: 10.1016/j.pain.2011.01.001.

2.

Physiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor.

Heinricher MM, Maire JJ, Lee D, Nalwalk JW, Hough LB.

J Neurophysiol. 2010 Dec;104(6):3222-30. doi: 10.1152/jn.00681.2010. Epub 2010 Oct 6.

3.

CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.

Hough LB, Nalwalk JW, Phillips JG, Kern B, Shan Z, Wentland MP, de Esch IJ, Janssen E, Barr T, Stadel R.

Neuropharmacology. 2007 Apr;52(5):1244-55. Epub 2007 Jan 20.

4.

Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.

Hough LB, de Esch IJ, Janssen E, Phillips J, Svokos K, Kern B, Trachler J, Abood ME, Leurs R, Nalwalk JW.

Neuropharmacology. 2006 Sep;51(3):447-56. Epub 2006 Jun 23.

PMID:
16806300
5.

A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic.

Svokos K, Nalwalk JW, Leurs R, Menge WM, Timmerman H, Hough LB.

Brain Res. 2001 Dec 27;923(1-2):12-9.

PMID:
11743967
6.

Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.

Hough LB, Nalwalk JW, Lu Q, Shan Z, Svokos K, Wentland MP, Montero MJ.

Eur J Pharmacol. 2005 Oct 17;522(1-3):38-46. Epub 2005 Oct 10.

PMID:
16216240
8.

Significance of cannabinoid CB1 receptors in improgan antinociception.

Gehani NC, Nalwalk JW, Razdan RK, Martin BR, Sun X, Wentland M, Abood ME, Hough LB.

J Pain. 2007 Nov;8(11):850-60. Epub 2007 Jul 23.

9.
10.

Significance of GABAergic systems in the action of improgan, a non-opioid analgesic.

Hough LB, Nalwalk JW, Leurs R, Menge WM, Timmerman H.

Life Sci. 2001 May 4;68(24):2751-7.

PMID:
11400917
11.

Neural basis for improgan antinociception.

Heinricher MM, Martenson ME, Nalwalk JW, Hough LB.

Neuroscience. 2010 Sep 1;169(3):1414-20. doi: 10.1016/j.neuroscience.2010.05.042. Epub 2010 May 24.

12.

Improgan antinociception does not require neuronal histamine or histamine receptors.

Izadi Mobarakeh J, Nalwalk JW, Watanabe T, Sakurada S, Hoffman M, Leurs R, Timmerman H, Silos-Santiago I, Yanai K, Hough LB.

Brain Res. 2003 Jun 6;974(1-2):146-52.

PMID:
12742632
13.

Antinociceptive activity of derivatives of improgran and burimamide.

Hough LB, Nalwalk JW, Leurs R, Menge WM, Timmerman H.

Pharmacol Biochem Behav. 2000 Jan 1;65(1):61-6.

PMID:
10638637
14.

Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception.

Nalwalk JW, Svokos K, Leurs R, Hough LB.

Pharmacol Biochem Behav. 2005 Mar;80(3):505-10.

PMID:
15740793
15.

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.

Hough LB, Nalwalk JW, Chen Y, Schuller A, Zhu Y, Zhang J, Menge WM, Leurs R, Timmerman H, Pintar JE.

Brain Res. 2000 Oct 13;880(1-2):102-8.

PMID:
11032994
16.

Antinociceptive activity of CC44, a biotinylated improgan congener.

Hoerbelt P, Nalwalk JW, Phillips JG, Wentland MP, Shan Z, Hough LB.

Eur J Pharmacol. 2013 Aug 15;714(1-3):464-71. doi: 10.1016/j.ejphar.2013.06.041. Epub 2013 Jul 5.

17.

CC12, a P450/epoxygenase inhibitor, acts in the rat rostral, ventromedial medulla to attenuate morphine antinociception.

Conroy JL, Nalwalk JW, Phillips JG, Hough LB.

Brain Res. 2013 Mar 7;1499:1-11. doi: 10.1016/j.brainres.2012.12.030. Epub 2013 Jan 5.

18.

Efficacy of improgan, a non-opioid analgesic, in neuropathic pain.

Albrecht PJ, Nalwalk JW, Hough LB.

Brain Res. 2011 Nov 18;1424:32-7. doi: 10.1016/j.brainres.2011.10.002. Epub 2011 Oct 8.

19.

Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.

Bannoura MD, Nalwalk JW, Tang Y, Carlile M, Leurs R, Menge WM, Timmerman H, Hough LB.

Brain Res. 1998 Dec 14;814(1-2):218-21.

PMID:
9838126
20.

Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms.

Hough LB, Svokos K, Nalwalk JW.

Brain Res. 2009 Jan 9;1247:62-70. doi: 10.1016/j.brainres.2008.10.008. Epub 2008 Oct 21.

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