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High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery.

Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T, Carey DJ, Gerhard GS.

Obesity (Silver Spring). 2011 Aug;19(8):1676-83. doi: 10.1038/oby.2011.3. Epub 2011 Feb 10.


Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.

Goergen M, Manzoni D, De Blasi V, Fabiano P, Poulain V, De Magistris L, Simonelli V, Dahan K, Azagra JS.

Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):7-24.


Association of morbid obesity with FTO and INSIG2 allelic variants.

Chu X, Erdman R, Susek M, Gerst H, Derr K, Al-Agha M, Wood GC, Hartman C, Yeager S, Blosky MA, Krum W, Stewart WF, Carey D, Benotti P, Still CD, Gerhard GS.

Arch Surg. 2008 Mar;143(3):235-40; discussion 241. doi: 10.1001/archsurg.2007.77.


Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations.

Parikh M, Hetherington J, Sheth S, Seiler J, Ostrer H, Gerhard G, Wood C, Still C.

Surg Obes Relat Dis. 2013 May-Jun;9(3):436-41. doi: 10.1016/j.soard.2012.04.004. Epub 2012 May 8.


Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.

Hunt SC, Hasstedt SJ, Xin Y, Dalley BK, Milash BA, Yakobson E, Gress RE, Davidson LE, Adams TD.

Obesity (Silver Spring). 2011 Nov;19(11):2241-7. doi: 10.1038/oby.2011.239. Epub 2011 Aug 4.


Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

Tan S, Scherag A, Janssen OE, Hahn S, Lahner H, Dietz T, Scherag S, Grallert H, Vogel CI, Kimmig R, Illig T, Mann K, Hebebrand J, Hinney A.

BMC Med Genet. 2010 Jan 21;11:12. doi: 10.1186/1471-2350-11-12.


Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.

Moore BS, Mirshahi UL, Yost EA, Stepanchick AN, Bedrin MD, Styer AM, Jackson KK, Still CD, Breitwieser GE, Gerhard GS, Carey DJ, Mirshahi T.

PLoS One. 2014 Apr 4;9(4):e93629. doi: 10.1371/journal.pone.0093629. eCollection 2014.


Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Santos JL, De la Cruz R, Holst C, Grau K, Naranjo C, Maiz A, Astrup A, Saris WH, MacDonald I, Oppert JM, Hansen T, Pedersen O, Sorensen TI, Martinez JA; NUGENOB Consortium.

PLoS One. 2011;6(6):e19934. doi: 10.1371/journal.pone.0019934. Epub 2011 Jun 14.


The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery.

Mirshahi UL, Still CD, Masker KK, Gerhard GS, Carey DJ, Mirshahi T.

J Clin Endocrinol Metab. 2011 Dec;96(12):E2088-96. doi: 10.1210/jc.2011-1549. Epub 2011 Oct 5.


Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.

Malzahn D, Müller-Nurasyid M, Heid IM, Wichmann HE; KORA study group, Bickeböller H.

Eur J Hum Genet. 2014 Oct;22(10):1217-24. doi: 10.1038/ejhg.2014.3. Epub 2014 Feb 12.


Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen AL, Marre M, Vol S, Tammelin T, Laitinen J, Gonzalez-Izquierdo A, Blakemore AI, Elliott P, Meyre D, Balkau B, Järvelin MR, Froguel P.

J Mol Med (Berl). 2009 May;87(5):537-46. doi: 10.1007/s00109-009-0451-6. Epub 2009 Mar 3.


Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.

Kvaløy K, Kulle B, Romundstad P, Holmen TL.

Int J Obes (Lond). 2013 Sep;37(9):1221-9. doi: 10.1038/ijo.2012.220. Epub 2013 Jan 15.


The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

Bressler J, Fornage M, Hanis CL, Kao WH, Lewis CE, McPherson R, Dent R, Mosley TH, Pennacchio LA, Boerwinkle E.

BMC Med Genet. 2009 Jun 12;10:56. doi: 10.1186/1471-2350-10-56.


Association of ghrelin receptor promoter polymorphisms with weight loss following Roux-en-Y gastric bypass surgery.

Matzko ME, Argyropoulos G, Wood GC, Chu X, McCarter RJ, Still CD, Gerhard GS.

Obes Surg. 2012 May;22(5):783-90. doi: 10.1007/s11695-012-0631-2.


Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population.

Sull JW, Lee M, Jee SH.

Endocrine. 2013 Dec;44(3):675-9. doi: 10.1007/s12020-013-9909-y. Epub 2013 Mar 5.


Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986.

Jääskeläinen A, Schwab U, Kolehmainen M, Kaakinen M, Savolainen MJ, Froguel P, Cauchi S, Järvelin MR, Laitinen J.

PLoS One. 2013 Sep 10;8(9):e73802. doi: 10.1371/journal.pone.0073802. eCollection 2013.


Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population.

Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, Lobbens S, Vatin V, Durand E, Labrune Y, Delplanque J, Meyre D, Froguel P.

Obesity (Silver Spring). 2012 Feb;20(2):389-95. doi: 10.1038/oby.2011.177. Epub 2011 Jun 30.


[Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population].

Kochetova OV, Korytina GF, Akhmadishina LZ, Semenov EE, Viktorova TV.

Genetika. 2015 Feb;51(2):248-55. Russian.


Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study.

Liem ET, Vonk JM, Sauer PJ, van der Steege G, Oosterom E, Stolk RP, Snieder H.

Am J Clin Nutr. 2010 Feb;91(2):321-8. doi: 10.3945/ajcn.2009.28186. Epub 2009 Dec 9.


Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.

Rinella ES, Still C, Shao Y, Wood GC, Chu X, Salerno B, Gerhard GS, Ostrer H.

J Clin Endocrinol Metab. 2013 Jun;98(6):E1131-6. doi: 10.1210/jc.2012-3421. Epub 2013 Apr 30.

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