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Items: 1 to 20 of 84

1.

Asparagine endopeptidase is required for normal kidney physiology and homeostasis.

Miller G, Matthews SP, Reinheckel T, Fleming S, Watts C.

FASEB J. 2011 May;25(5):1606-17. doi: 10.1096/fj.10-172312. Epub 2011 Feb 3.

PMID:
21292981
2.

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice.

Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I.

J Biol Chem. 2003 Aug 29;278(35):33194-9. Epub 2003 May 29.

3.

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.

Chan CB, Abe M, Hashimoto N, Hao C, Williams IR, Liu X, Nakao S, Yamamoto A, Zheng C, Henter JI, Meeths M, Nordenskjold M, Li SY, Hara-Nishimura I, Asano M, Ye K.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):468-73. doi: 10.1073/pnas.0809824105. Epub 2008 Dec 23. Erratum in: Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):6023. Zheng, Chengyun [added]; Henter, Jan-Inge [added]; Meeths, Marie [added]; Nordenskjold, Magnus [added].

4.

Distinct protease requirements for antigen presentation in vitro and in vivo.

Matthews SP, Werber I, Deussing J, Peters C, Reinheckel T, Watts C.

J Immunol. 2010 Mar 1;184(5):2423-31. doi: 10.4049/jimmunol.0901486.

5.

Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats.

Hayden MR, Habibi J, Whaley-Connell A, Sowers D, Johnson M, Tilmon R, Jain D, Ferrario C, Sowers JR.

Am J Nephrol. 2010;31(3):262-72. doi: 10.1159/000278757. Epub 2010 Jan 25.

6.

ADAM19 expression in human nephrogenesis and renal disease: associations with clinical and structural deterioration.

Melenhorst WB, van den Heuvel MC, Timmer A, Huitema S, Bulthuis M, Timens W, van Goor H.

Kidney Int. 2006 Oct;70(7):1269-78. Epub 2006 Aug 9.

7.

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

Li DN, Matthews SP, Antoniou AN, Mazzeo D, Watts C.

J Biol Chem. 2003 Oct 3;278(40):38980-90. Epub 2003 Jul 14.

8.

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL.

J Immunol. 2005 Jun 1;174(11):7066-74.

9.

Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.

Morita Y, Araki H, Sugimoto T, Takeuchi K, Yamane T, Maeda T, Yamamoto Y, Nishi K, Asano M, Shirahama-Noda K, Nishimura M, Uzu T, Hara-Nishimura I, Koya D, Kashiwagi A, Ohkubo I.

FEBS Lett. 2007 Apr 3;581(7):1417-24. Epub 2007 Mar 5. Erratum in: FEBS Lett. 2007 Jul 24;581(18):3579.

10.

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells.

Sepulveda FE, Maschalidi S, Colisson R, Heslop L, Ghirelli C, Sakka E, Lennon-Duménil AM, Amigorena S, Cabanie L, Manoury B.

Immunity. 2009 Nov 20;31(5):737-48. doi: 10.1016/j.immuni.2009.09.013. Epub 2009 Oct 29.

11.

ADAM17 upregulation in human renal disease: a role in modulating TGF-alpha availability?

Melenhorst WB, Visser L, Timmer A, van den Heuvel MC, Stegeman CA, van Goor H.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F781-90. doi: 10.1152/ajprenal.90610.2008. Epub 2009 Jun 17.

PMID:
19535569
12.

Glomerular filtration and tubular absorption of the basic polypeptide aprotinin.

Tenstad O, Williamson HE, Clausen G, Oien AH, Aukland K.

Acta Physiol Scand. 1994 Sep;152(1):33-50.

PMID:
7528967
13.

Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis.

Lin Y, Qiu Y, Xu C, Liu Q, Peng B, Kaufmann GF, Chen X, Lan B, Wei C, Lu D, Zhang Y, Guo Y, Lu Z, Jiang B, Edgington TS, Guo F.

J Natl Cancer Inst. 2014 Apr;106(4):dju012. doi: 10.1093/jnci/dju012. Epub 2014 Mar 7.

PMID:
24610907
14.

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

Manoury B, Hewitt EW, Morrice N, Dando PM, Barrett AJ, Watts C.

Nature. 1998 Dec 17;396(6712):695-9.

PMID:
9872320
15.

The effect of progressive glomerular disease on megalin-mediated endocytosis in the kidney.

Vinge L, Lees GE, Nielsen R, Kashtan CE, Bahr A, Christensen EI.

Nephrol Dial Transplant. 2010 Aug;25(8):2458-67. doi: 10.1093/ndt/gfq044. Epub 2010 Mar 2.

16.

Modification of immunoreactive EGF and EGF receptor after acute tubular necrosis induced by tobramycin or cisplatin.

Leonard I, Zanen J, Nonclercq D, Toubeau G, Heuson-Stiennon JA, Beckers JF, Falmagne P, Schaudies RP, Laurent G.

Ren Fail. 1994;16(5):583-608.

PMID:
7855315
17.

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.

Zhang Z, Xie M, Ye K.

Expert Opin Ther Targets. 2016 Oct;20(10):1237-45. doi: 10.1080/14728222.2016.1182990. Epub 2016 May 13. Review.

18.

Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.

Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K.

Mol Cell Biol. 2005 Sep;25(17):7770-9.

19.

The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.

Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD.

Kidney Int. 2007 Mar;71(6):504-13. Epub 2007 Jan 17.

20.

Taxol inhibits endosomal-lysosomal membrane trafficking at two distinct steps in CV-1 cells.

Sonee M, Barrón E, Yarber FA, Hamm-Alvarez SF.

Am J Physiol. 1998 Dec;275(6 Pt 1):C1630-9.

PMID:
9843725

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