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The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.

Gildea DE, Luetkemeier ES, Bao X, Loftus SK, Mackem S, Yang Y, Pavan WJ, Biesecker LG.

FASEB J. 2011 May;25(5):1596-605. doi: 10.1096/fj.10-169771.


Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.

Quinn ME, Haaning A, Ware SM.

Hum Mol Genet. 2012 Apr 15;21(8):1888-96. doi: 10.1093/hmg/dds002.


Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.

Büscher D, Bosse B, Heymer J, Rüther U.

Mech Dev. 1997 Mar;62(2):175-82.


Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog.

Babbs C, Furniss D, Morriss-Kay GM, Wilkie AO.

Mech Dev. 2008 May-Jun;125(5-6):517-26. doi: 10.1016/j.mod.2008.01.001.


Expression of SHH signaling pathway components in the developing human lung.

Zhang M, Wang H, Teng H, Shi J, Zhang Y.

Histochem Cell Biol. 2010 Oct;134(4):327-35. doi: 10.1007/s00418-010-0738-2.


The molecular basis of Pallister Hall associated polydactyly.

Hill P, Wang B, Rüther U.

Hum Mol Genet. 2007 Sep 1;16(17):2089-96.


Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.

Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C.

Development. 2009 Oct;136(20):3515-24. doi: 10.1242/dev.037507.


Sonic hedgehog expression and its role in form-deprivation myopia in mice.

Qian YS, Chu RY, Hu M, Hoffman MR.

Curr Eye Res. 2009 Aug;34(8):623-35.


Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.

Krebs O, Schreiner CM, Scott WJ Jr, Bell SM, Robbins DJ, Goetz JA, Alt H, Hawes N, Wolf E, Favor J.

Development. 2003 Dec;130(24):6037-47.


Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.

Dakubo GD, Beug ST, Mazerolle CJ, Thurig S, Wang Y, Wallace VA.

Brain Res. 2008 Sep 4;1228:27-42. doi: 10.1016/j.brainres.2008.06.058.


Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

te Welscher P, Zuniga A, Kuijper S, Drenth T, Goedemans HJ, Meijlink F, Zeller R.

Science. 2002 Oct 25;298(5594):827-30.


Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.

Cao T, Wang C, Yang M, Wu C, Wang B.

Dev Biol. 2013 Jul 15;379(2):221-8. doi: 10.1016/j.ydbio.2013.04.025.


Sonic hedgehog expression in Gli3 depressed mouse embryo, Pdn/Pdn.

Ueta E, Maekawa M, Morimoto I, Nanba E, Naruse I.

Congenit Anom (Kyoto). 2004 Mar;44(1):27-32.


Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.

Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN.

Hum Mol Genet. 2009 May 15;18(10):1719-39. doi: 10.1093/hmg/ddp075.


Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development.

McGlinn E, van Bueren KL, Fiorenza S, Mo R, Poh AM, Forrest A, Soares MB, Bonaldo Mde F, Grimmond S, Hui CC, Wainwright B, Wicking C.

Mech Dev. 2005 Nov;122(11):1218-33.


Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin.

Li J, Wang Q, Cui Y, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z.

PLoS One. 2015 May 22;10(5):e0128006. doi: 10.1371/journal.pone.0128006.


Neogenin regulates Sonic Hedgehog pathway activity during digit patterning.

Hong M, Schachter KA, Jiang G, Krauss RS.

Dev Dyn. 2012 Mar;241(3):627-37. doi: 10.1002/dvdy.23745.


Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.

DeSouza KR, Saha M, Carpenter AR, Scott M, McHugh KM.

PLoS One. 2013;8(1):e53675. doi: 10.1371/journal.pone.0053675.


Shh and Gli3 activities are required for timely generation of motor neuron progenitors.

Oh S, Huang X, Liu J, Litingtung Y, Chiang C.

Dev Biol. 2009 Jul 15;331(2):261-9. doi: 10.1016/j.ydbio.2009.05.539.

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