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Items: 1 to 20 of 186

1.

Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.

Matsumura S, Shinoda K, Yamada M, Yokojima S, Inoue M, Ohnishi T, Shimada T, Kikuchi K, Masui D, Hashimoto S, Sato M, Ito A, Akioka M, Takagi S, Nakamura Y, Nemoto K, Hasegawa Y, Takamoto H, Inoue H, Nakamura S, Nabeshima Y, Teplow DB, Kinjo M, Hoshi M.

J Biol Chem. 2011 Apr 1;286(13):11555-62. doi: 10.1074/jbc.M110.181313. Epub 2011 Feb 3.

2.

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, Akioka M, Kikuchi S, Sato M, Ideno S, Noda M, Fukunari A, Muramatsu S, Itokazu Y, Sato K, Takahashi H, Teplow DB, Nabeshima Y, Kakita A, Imahori K, Hoshi M.

J Biol Chem. 2009 Nov 20;284(47):32895-905. doi: 10.1074/jbc.M109.000208. Epub 2009 Sep 15.

3.

S14G-humanin inhibits Aβ1-42 fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity in vitro.

Zhang W, Du Y, Bai M, Xi Y, Li Z, Miao J.

J Pept Sci. 2013 Mar;19(3):159-65. doi: 10.1002/psc.2484. Epub 2013 Jan 24. Erratum in: J Pept Sci. 2016 Jun;22(6):434.

PMID:
23349038
4.

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.

Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PJ, Pfeifer A, Muhs A, Lashuel HA.

J Biol Chem. 2011 Mar 11;286(10):8585-96. doi: 10.1074/jbc.M110.172411. Epub 2010 Dec 14.

5.

A strategy for designing a peptide probe for detection of β-amyloid oligomers.

Hu Y, Su B, Kim CS, Hernandez M, Rostagno A, Ghiso J, Kim JR.

Chembiochem. 2010 Nov 22;11(17):2409-18. doi: 10.1002/cbic.201000435.

PMID:
21031399
6.

How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters.

Matsuzaki K.

Acc Chem Res. 2014 Aug 19;47(8):2397-404. doi: 10.1021/ar500127z. Epub 2014 Jul 16.

PMID:
25029558
7.

Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM.

Norlin N, Hellberg M, Filippov A, Sousa AA, Gröbner G, Leapman RD, Almqvist N, Antzutkin ON.

J Struct Biol. 2012 Oct;180(1):174-89. doi: 10.1016/j.jsb.2012.06.010. Epub 2012 Jun 28.

8.

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils.

Poduslo JF, Howell KG, Olson NC, Ramirez-Alvarado M, Kandimalla KK.

Biochemistry. 2012 May 15;51(19):3993-4003. doi: 10.1021/bi300275g. Epub 2012 May 7.

PMID:
22545812
9.

Stability of Aβ (1-42) peptide fibrils as consequence of environmental modifications.

Gregori M, Cassina V, Brogioli D, Salerno D, De Kimpe L, Scheper W, Masserini M, Mantegazza F.

Eur Biophys J. 2010 Nov;39(12):1613-23. doi: 10.1007/s00249-010-0619-6. Epub 2010 Aug 9.

PMID:
20694815
10.

Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.

Yan LM, Velkova A, Kapurniotu A.

Curr Pharm Des. 2014;20(8):1182-91.

PMID:
23713771
11.

Effects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization.

Bett CK, Serem WK, Fontenot KR, Hammer RP, Garno JC.

ACS Chem Neurosci. 2010 Oct 20;1(10):661-78. doi: 10.1021/cn900019r. Epub 2010 Aug 26.

12.

Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.

Agopian A, Guo Z.

Biochem J. 2012 Oct 1;447(1):43-50. doi: 10.1042/BJ20120034.

PMID:
22823461
13.

The Alzheimer's amyloid-β(1-42) peptide forms off-pathway oligomers and fibrils that are distinguished structurally by intermolecular organization.

Tay WM, Huang D, Rosenberry TL, Paravastu AK.

J Mol Biol. 2013 Jul 24;425(14):2494-508. doi: 10.1016/j.jmb.2013.04.003. Epub 2013 Apr 11.

PMID:
23583777
14.

Studies of the growth, evolution, and self-aggregation of β-amyloid fibrils using tapping-mode atomic force microscopy.

Serem WK, Bett CK, Ngunjiri JN, Garno JC.

Microsc Res Tech. 2011 Jul;74(7):699-708. doi: 10.1002/jemt.20940. Epub 2010 Nov 3.

PMID:
21698718
15.

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.

Sandberg A, Luheshi LM, Söllvander S, Pereira de Barros T, Macao B, Knowles TP, Biverstål H, Lendel C, Ekholm-Petterson F, Dubnovitsky A, Lannfelt L, Dobson CM, Härd T.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15595-600. doi: 10.1073/pnas.1001740107. Epub 2010 Aug 16.

16.

N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly.

Liao MC, Hoos MD, Aucoin D, Ahmed M, Davis J, Smith SO, Van Nostrand WE.

J Biol Chem. 2010 Nov 12;285(46):35590-8. doi: 10.1074/jbc.M110.169599. Epub 2010 Aug 31.

17.

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity.

Bolognin S, Messori L, Drago D, Gabbiani C, Cendron L, Zatta P.

Int J Biochem Cell Biol. 2011 Jun;43(6):877-85. doi: 10.1016/j.biocel.2011.02.009. Epub 2011 Mar 3.

PMID:
21376832
19.

Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.

Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.

Biochim Biophys Acta. 2010 Apr;1804(4):986-95. doi: 10.1016/j.bbapap.2010.01.012. Epub 2010 Jan 25.

PMID:
20100601
20.

Α-mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation.

Wang Y, Xia Z, Xu JR, Wang YX, Hou LN, Qiu Y, Chen HZ.

Neuropharmacology. 2012 Feb;62(2):871-81. doi: 10.1016/j.neuropharm.2011.09.016. Epub 2011 Sep 24.

PMID:
21958557

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