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Items: 1 to 20 of 221

1.

The design and synthesis of libraries for the discovery of antibacterial and antifungal substances.

Edwards PJ.

Drug Discov Today. 2011 Mar;16(5-6):278-9. doi: 10.1016/j.drudis.2011.01.010. Epub 2011 Jan 28. No abstract available.

PMID:
21277383
2.

The discovery of antibacterial agents using diversity-oriented synthesis.

Galloway WR, Bender A, Welch M, Spring DR.

Chem Commun (Camb). 2009 May 14;(18):2446-62. doi: 10.1039/b816852k. Epub 2009 Apr 1. Review.

PMID:
19532856
3.

Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.

López-Vallejo F, Caulfield T, Martínez-Mayorga K, Giulianotti MA, Nefzi A, Houghten RA, Medina-Franco JL.

Comb Chem High Throughput Screen. 2011 Jul;14(6):475-87. Review.

PMID:
21521151
4.

Synthesis and antibiotic activity of a small molecules library of 1,2,3-triazole derivatives.

Aufort M, Herscovici J, Bouhours P, Moreau N, Girard C.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1195-8. Epub 2007 Dec 4.

PMID:
18086525
5.

Combinatorial chemistry in the agrosciences.

Lindell SD, Pattenden LC, Shannon J.

Bioorg Med Chem. 2009 Jun 15;17(12):4035-46. doi: 10.1016/j.bmc.2009.03.027. Epub 2009 Mar 19. Review.

PMID:
19349185
6.

Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors.

Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Cheng WC.

Org Biomol Chem. 2010 Jun 7;8(11):2586-93. doi: 10.1039/c000622j. Epub 2010 Mar 29.

PMID:
20485795
7.

Molecular library design using multi-objective optimization methods.

Nicolaou CA, Kannas CC.

Methods Mol Biol. 2011;685:53-69. doi: 10.1007/978-1-60761-931-4_3.

PMID:
20981518
8.

Patent review.

McGee JE, Roy A.

Comb Chem High Throughput Screen. 2011 Dec;14(10):926-8. No abstract available.

PMID:
21864291
9.

Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery.

Ziora ZM, Wimmer N, New R, Skwarczynski M, Toth I.

Carbohydr Res. 2011 Sep 6;346(12):1439-44. doi: 10.1016/j.carres.2011.03.019. Epub 2011 Mar 15.

PMID:
21641587
10.

Combinatorial library design from reagent pharmacophore fingerprints.

Chen H, Engkvist O, Blomberg N.

Methods Mol Biol. 2011;685:135-52. doi: 10.1007/978-1-60761-931-4_7.

PMID:
20981522
11.

A scalable approach to combinatorial library design.

Sharma P, Salapaka S, Beck C.

Methods Mol Biol. 2011;685:71-89. doi: 10.1007/978-1-60761-931-4_4.

PMID:
20981519
12.

Liquid-phase combinatorial library synthesis: recent advances and future perspectives.

Barot KP, Nikolova S, Ivanov I, Ghate MD.

Comb Chem High Throughput Screen. 2014;17(5):417-38. Review.

PMID:
24237348
13.

Recent trends and observations in the design of high-quality screening collections.

Renner S, Popov M, Schuffenhauer A, Roth HJ, Breitenstein W, Marzinzik A, Lewis I, Krastel P, Nigsch F, Jenkins J, Jacoby E.

Future Med Chem. 2011 Apr;3(6):751-66. doi: 10.4155/fmc.11.15. Review.

PMID:
21554080
14.

From fragment screening to potent binders: strategies for fragment-to-lead evolution.

Eitner K, Koch U.

Mini Rev Med Chem. 2009 Jul;9(8):956-61. Review.

PMID:
19601891
15.

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.

Westwood IM, Kawamura A, Russell AJ, Sandy J, Davies SG, Sim E.

Comb Chem High Throughput Screen. 2011 Feb;14(2):117-24.

PMID:
21118080
16.

Historical overview of chemical library design.

Dolle RE.

Methods Mol Biol. 2011;685:3-25. doi: 10.1007/978-1-60761-931-4_1. Review.

PMID:
20981516
17.

Use of mathematical structural invariants in analyzing combinatorial libraries: a case study with psoralen derivatives.

Basak SC, Mills D, Gute BD, Balaban AT, Basak K, Grunwald GD.

Curr Comput Aided Drug Des. 2010 Dec;6(4):240-51.

PMID:
20883202
18.

Combinatorial discovery of fluorescent pharmacophores by multicomponent reactions in droplet arrays.

Burchak ON, Mugherli L, Ostuni M, Lacapère JJ, Balakirev MY.

J Am Chem Soc. 2011 Jul 6;133(26):10058-61. doi: 10.1021/ja204016e. Epub 2011 Jun 14.

PMID:
21644551
19.

Current parallel chemistry principles and practice: application to the discovery of biologically active molecules.

Edwards PJ.

Curr Opin Drug Discov Devel. 2009 Nov;12(6):899-914. Review.

PMID:
19894197
20.

How to discover new antibiotics: harvesting the parvome.

Davies J.

Curr Opin Chem Biol. 2011 Feb;15(1):5-10. doi: 10.1016/j.cbpa.2010.11.001. Epub 2010 Nov 24. Review.

PMID:
21111668

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