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Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for a double-blinded, randomised clinical trial.

Perner A, Haase N, Wetterslev J, Aneman A, Tenhunen J, Guttormsen AB, Klemenzson G, Pott F, Bødker KD, Bådstøløkken PM, Bendtsen A, Søe-Jensen P, Tousi H, Bestle M, Pawlowicz M, Winding R, Bülow HH, Kancir C, Steensen M, Nielsen J, Fogh B, Madsen KR, Larsen NH, Carlsson M, Wiis J, Petersen JA, Iversen S, Schøidt O, Leivdal S, Berezowicz P, Pettilä V, Ruokonen E, Klepstad P, Karlsson S, Kaukonen M, Rutanen J, Karason S, Kjældgaard AL, Holst LB, Wernerman J; Scandinavian Critical Care Trials Group..

Trials. 2011 Jan 27;12:24. doi: 10.1186/1745-6215-12-24.


Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.

Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjældgaard AL, Fabritius ML, Mondrup F, Pott FC, Møller TP, Winkel P, Wetterslev J; 6S Trial Group.; Scandinavian Critical Care Trials Group..

N Engl J Med. 2012 Jul 12;367(2):124-34. doi: 10.1056/NEJMoa1204242. Epub 2012 Jun 27. Erratum in: N Engl J Med. 2012 Aug 2;367(5):481.


Hydroxyethyl starch in severe sepsis: end of starch era?

Estrada CA, Murugan R.

Crit Care. 2013 Mar 13;17(2):310. doi: 10.1186/cc12531.


Hydroxyethyl starch in sepsis.

Haase NR.

Dan Med J. 2014 Jan;61(1):B4764.


Acute kidney injury with hydroxyethyl starch 130/0.42 in severe sepsis.

Müller RB, Haase N, Lange T, Wetterslev J, Perner A.

Acta Anaesthesiol Scand. 2015 Mar;59(3):329-36. doi: 10.1111/aas.12453. Epub 2014 Dec 18.


Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate.

Perner A, Haase N, Winkel P, Guttormsen AB, Tenhunen J, Klemenzson G, Müller RG, Aneman A, Wetterslev J.

Intensive Care Med. 2014 Jul;40(7):927-34. doi: 10.1007/s00134-014-3311-y. Epub 2014 May 8.


Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial.

Béchir M, Puhan MA, Fasshauer M, Schuepbach RA, Stocker R, Neff TA.

Crit Care. 2013 Dec 23;17(6):R299. doi: 10.1186/cc13168.


Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review and meta-analysis of the literature.

Serpa Neto A, Veelo DP, Peireira VG, de Assunção MS, Manetta JA, Espósito DC, Schultz MJ.

J Crit Care. 2014 Feb;29(1):185.e1-7. doi: 10.1016/j.jcrc.2013.09.031. Epub 2013 Oct 22. Review.


Effects of hydroxyethyl starch in subgroups of patients with severe sepsis: exploratory post-hoc analyses of a randomised trial.

Müller RG, Haase N, Wetterslev J, Perner A.

Intensive Care Med. 2013 Nov;39(11):1963-71. doi: 10.1007/s00134-013-3090-x. Epub 2013 Sep 14.


Individual patient data meta-analysis of hydroxyethyl starch 130/0.4-0.42 versus crystalloid for fluid resuscitation in patients with severe sepsis: a statistical analysis plan.

Hammond NE, Haase N, Billot L, Wetterslev J, Saxena MK, Finfer S, Perner A, Myburgh J.

Crit Care Resusc. 2014 Jun;16(2):96-103.


Markers of endothelial damage and coagulation impairment in patients with severe sepsis resuscitated with hydroxyethyl starch 130/0.42 vs Ringer acetate.

Müller RB, Ostrowski SR, Haase N, Wetterslev J, Perner A, Johansson PI.

J Crit Care. 2016 Apr;32:16-20. doi: 10.1016/j.jcrc.2015.11.025. Epub 2015 Dec 8.


[The design of the VISEP trial. Critical appraisal].

Zander R, Boldt J, Engelmann L, Mertzlufft F, Sirtl C, Stuttmann R.

Anaesthesist. 2007 Jan;56(1):71-7. German.


Thromboelastography in patients with severe sepsis: a prospective cohort study.

Haase N, Ostrowski SR, Wetterslev J, Lange T, Møller MH, Tousi H, Steensen M, Pott F, Søe-Jensen P, Nielsen J, Hjortrup PB, Johansson PI, Perner A.

Intensive Care Med. 2015 Jan;41(1):77-85. doi: 10.1007/s00134-014-3552-9. Epub 2014 Nov 21.


Crystalloids vs. colloids: KO at the twelfth round?

Phillips DP, Kaynar AM, Kellum JA, Gomez H.

Crit Care. 2013 May 29;17(3):319. doi: 10.1186/cc12708.


Comparison of three fluid solutions for resuscitation in dengue shock syndrome.

Wills BA, Nguyen MD, Ha TL, Dong TH, Tran TN, Le TT, Tran VD, Nguyen TH, Nguyen VC, Stepniewska K, White NJ, Farrar JJ.

N Engl J Med. 2005 Sep 1;353(9):877-89.


Quality of life and pruritus in patients with severe sepsis resuscitated with hydroxyethyl starch long-term follow-up of a randomised trial.

Wittbrodt P, Haase N, Butowska D, Winding R, Poulsen JB, Perner A; 6S trial group.; Scandinavian Critical Care Trials Group..

Crit Care. 2013 Feb 25;17(2):R58. doi: 10.1186/cc12586.


Bleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial.

Haase N, Wetterslev J, Winkel P, Perner A.

Intensive Care Med. 2013 Dec;39(12):2126-34. doi: 10.1007/s00134-013-3111-9. Epub 2013 Oct 1.


[The influence of hydroxyethyl starch on exogenous coagulation and active protein C in patients with septic shock].

Lyu J, Li T, Liu F, An Y.

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jan;27(1):28-32. doi: 10.3760/cma.j.issn.2095-4352.2015.01.007. Chinese.


Molecular weight and molar substitution are more important in HES-induced renal impairment than concentration after hemorrhagic and septic shock.

Simon TP, Thiele C, Schuerholz T, Fries M, Stadermann F, Haase G, Amann KU, Marx G.

Minerva Anestesiol. 2015 Jun;81(6):608-18. Epub 2014 Oct 9.


Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis.

Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, Wetterslev J.

BMJ. 2013 Feb 15;346:f839. doi: 10.1136/bmj.f839. Review.

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