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Items: 1 to 20 of 87

1.

Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells.

Fatrai S, Wierenga AT, Daenen SM, Vellenga E, Schuringa JJ.

Blood. 2011 Mar 24;117(12):3320-30. doi: 10.1182/blood-2010-08-303669. Epub 2011 Jan 24.

2.

Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation.

Wierenga AT, Vellenga E, Schuringa JJ.

Blood. 2010 Jun 3;115(22):4367-76. doi: 10.1182/blood-2009-10-250894. Epub 2010 Mar 25.

3.

STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha.

Wierenga AT, Schepers H, Moore MA, Vellenga E, Schuringa JJ.

Blood. 2006 Jun 1;107(11):4326-33. Epub 2006 Feb 2.

4.

STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells.

Schepers H, van Gosliga D, Wierenga AT, Eggen BJ, Schuringa JJ, Vellenga E.

Blood. 2007 Oct 15;110(8):2880-8. Epub 2007 Jul 13.

5.

Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells.

Moore MA, Dorn DC, Schuringa JJ, Chung KY, Morrone G.

Exp Hematol. 2007 Apr;35(4 Suppl 1):105-16.

PMID:
17379095
6.

Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses.

Han L, Wierenga AT, Rozenveld-Geugien M, van de Lande K, Vellenga E, Schuringa JJ.

PLoS One. 2009 Nov 24;4(11):e7989. doi: 10.1371/journal.pone.0007989.

7.

Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels.

Wierenga AT, Vellenga E, Schuringa JJ.

Mol Cell Biol. 2008 Nov;28(21):6668-80. doi: 10.1128/MCB.01025-08. Epub 2008 Sep 8.

8.

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.

Kato Y, Iwama A, Tadokoro Y, Shimoda K, Minoguchi M, Akira S, Tanaka M, Miyajima A, Kitamura T, Nakauchi H.

J Exp Med. 2005 Jul 4;202(1):169-79.

9.

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.

Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.

Exp Hematol. 2009 Nov;37(11):1364-1377.e4. doi: 10.1016/j.exphem.2009.09.001. Epub 2009 Sep 8.

PMID:
19744539
10.

Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage.

Järås M, Johnels P, Agerstam H, Lassen C, Rissler M, Edén P, Cammenga J, Olofsson T, Bjerrum OW, Richter J, Fan X, Fioretos T.

Exp Hematol. 2009 Mar;37(3):367-75. doi: 10.1016/j.exphem.2008.11.003. Epub 2009 Jan 9.

PMID:
19135771
11.

Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis.

Olthof SG, Fatrai S, Drayer AL, Tyl MR, Vellenga E, Schuringa JJ.

Stem Cells. 2008 Jul;26(7):1732-42. doi: 10.1634/stemcells.2007-0899. Epub 2008 Apr 24.

12.

Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules.

Giron-Michel J, Caignard A, Fogli M, Brouty-Boyé D, Briard D, van Dijk M, Meazza R, Ferrini S, Lebousse-Kerdilès C, Clay D, Bompais H, Chouaib S, Péault B, Azzarone B.

Blood. 2003 Jul 1;102(1):109-17. Epub 2003 Mar 6.

13.

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.

Lacombe J, Herblot S, Rojas-Sutterlin S, Haman A, Barakat S, Iscove NN, Sauvageau G, Hoang T.

Blood. 2010 Jan 28;115(4):792-803. doi: 10.1182/blood-2009-01-201384. Epub 2009 Oct 22.

14.

SCL expression at critical points in human hematopoietic lineage commitment.

Zhang Y, Payne KJ, Zhu Y, Price MA, Parrish YK, Zielinska E, Barsky LW, Crooks GM.

Stem Cells. 2005 Jun-Jul;23(6):852-60.

15.

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells.

Buitenhuis M, Baltus B, Lammers JW, Coffer PJ, Koenderman L.

Blood. 2003 Jan 1;101(1):134-42. Epub 2002 Aug 15.

16.

Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis.

Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ.

Blood. 2009 Aug 20;114(8):1498-505. doi: 10.1182/blood-2009-03-209734. Epub 2009 Jun 25.

17.

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B.

Genes Dev. 2006 Mar 1;20(5):557-70.

18.

Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.

Li G, Wang Z, Miskimen KL, Zhang Y, Tse W, Bunting KD.

PLoS One. 2010 Feb 10;5(2):e9152. doi: 10.1371/journal.pone.0009152.

19.

Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells.

Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, Imai Y, Kurokawa M.

Oncogene. 2009 Dec 10;28(49):4364-74. doi: 10.1038/onc.2009.288. Epub .

PMID:
19767769
20.

HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding.

Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI.

Stem Cells. 2006 Apr;24(4):876-88. Epub 2006 Mar 2.

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