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Items: 1 to 20 of 106

1.

Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides.

Seth PP, Yu J, Allerson CR, Berdeja A, Swayze EE.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1122-5. doi: 10.1016/j.bmcl.2010.12.119. Epub 2010 Dec 31.

PMID:
21256012
2.

Synthesis and biophysical evaluation of 3'-Me-α-L-LNA - Substitution in the minor groove of α-L-LNA duplexes.

Seth PP, Allerson CA, Østergaard ME, Swayze EE.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4690-4. doi: 10.1016/j.bmcl.2011.06.104. Epub 2011 Jun 30.

PMID:
21778053
3.

Synthesis of a 2'-amino-alpha-1-LNA-T phosphoramidite.

Hrdlicka PJ, Kumar TS, Wengel J.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1101-4.

PMID:
16248100
4.

Structural requirements for hybridization at the 5'-position are different in α-l-LNA as compared to β-D-LNA.

Seth PP, Allerson CR, Ostergaard ME, Swayze EE.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):296-9. doi: 10.1016/j.bmcl.2011.11.012. Epub 2011 Nov 11.

PMID:
22153935
5.

Synthesis of bicyclic 2'-deoxynucleosides with alpha-L-ribo- and beta-D-xylo-configurations and restricted S- and N-type conformations.

Shaikh KI, Kumar S, Lundhus L, Bond AD, Sharma PK, Nielsen P.

J Org Chem. 2009 Feb 20;74(4):1557-66. doi: 10.1021/jo8023472.

PMID:
19154130
6.

Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.

Li Q, Yuan F, Zhou C, Plashkevych O, Chattopadhyaya J.

J Org Chem. 2010 Sep 17;75(18):6122-40. doi: 10.1021/jo100900v.

PMID:
20738147
7.

Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.

Upadhayaya R, Deshpande SG, Li Q, Kardile RA, Sayyed AY, Kshirsagar EK, Salunke RV, Dixit SS, Zhou C, Földesi A, Chattopadhyaya J.

J Org Chem. 2011 Jun 3;76(11):4408-31. doi: 10.1021/jo200073q. Epub 2011 May 4.

PMID:
21500818
8.

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites.

Kumar TS, Madsen AS, Østergaard ME, Wengel J, Hrdlicka PJ.

J Org Chem. 2008 Sep 19;73(18):7060-6. doi: 10.1021/jo800551j. Epub 2008 Aug 19.

PMID:
18710289
9.

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.

Seth PP, Allerson CR, Siwkowski A, Vasquez G, Berdeja A, Migawa MT, Gaus H, Prakash TP, Bhat B, Swayze EE.

J Med Chem. 2010 Dec 9;53(23):8309-18. doi: 10.1021/jm101207e. Epub 2010 Nov 8.

PMID:
21058707
10.

2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): synthesis and triplex-forming properties.

Obika S, Uneda T, Sugimoto T, Nanbu D, Minami T, Doi T, Imanishi T.

Bioorg Med Chem. 2001 Apr;9(4):1001-11.

PMID:
11354656
11.

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE.

J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f.

PMID:
20136157
12.
13.

Replacing the 2'-oxygen with an exocyclic methylene group reverses the stabilization effects of α-L-LNA.

Seth PP, Allerson CR, Berdeja A, Swayze EE.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):588-91. doi: 10.1016/j.bmcl.2010.10.025. Epub 2010 Oct 14.

PMID:
21075634
14.

C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability.

Kumar P, Baral B, Anderson BA, Guenther DC, Østergaard ME, Sharma PK, Hrdlicka PJ.

J Org Chem. 2014 Jun 6;79(11):5062-73. doi: 10.1021/jo5006153. Epub 2014 May 13.

15.

BNAs: novel nucleic acid analogs with a bridged sugar moiety.

Imanishi T, Obika S.

Chem Commun (Camb). 2002 Aug 21;(16):1653-9. Review.

PMID:
12196936
16.

Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.

Zhou C, Plashkevych O, Chattopadhyaya J.

J Org Chem. 2009 May 1;74(9):3248-65. doi: 10.1021/jo900391n.

PMID:
19348480
17.

Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.

Kumar TS, Madsen AS, Wengel J, Hrdlicka PJ.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1403-5.

PMID:
18066792
18.

LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.

Wengel J, Petersen M, Nielsen KE, Jensen GA, Håkansson AE, Kumar R, Sørensen MD, Rajwanshi VK, Bryld T, Jacobsen JP.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):389-96.

PMID:
11563053
19.

Synthesis and properties of a novel bridged nucleic acid analogue, 5'-amino-3',5'-BNA.

Sekiguchi M, Obika S, Somjing R, Imanishi T.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1097-100.

PMID:
16248099

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