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Items: 1 to 20 of 122

1.

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.

Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ.

Nature. 2011 Jan 20;469(7330):428-31. doi: 10.1038/nature09647.

PMID:
21248852
3.

A series of propofol analogs design by targeting pentameric ligand-gated ion channel in silico method.

Gao J, Wu XH, Dong WL, Wang SQ.

Protein Pept Lett. 2013 Nov;20(11):1238-45.

PMID:
23848595
4.
5.

Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics.

Tillman T, Cheng MH, Chen Q, Tang P, Xu Y.

Biochem J. 2013 Jan 1;449(1):61-8. doi: 10.1042/BJ20121072.

6.

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA.

Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692.

7.

Isoflurane alters the structure and dynamics of GLIC.

Willenbring D, Liu LT, Mowrey D, Xu Y, Tang P.

Biophys J. 2011 Oct 19;101(8):1905-12. doi: 10.1016/j.bpj.2011.09.026.

8.

Anesthetic binding in a pentameric ligand-gated ion channel: GLIC.

Chen Q, Cheng MH, Xu Y, Tang P.

Biophys J. 2010 Sep 22;99(6):1801-9. doi: 10.1016/j.bpj.2010.07.023.

9.

Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine.

Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P.

Structure. 2012 Sep 5;20(9):1463-9. doi: 10.1016/j.str.2012.08.009.

10.

Photoaffinity labeling the propofol binding site in GLIC.

Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB.

Biochemistry. 2014 Jan 14;53(1):135-42. doi: 10.1021/bi401492k.

11.

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E.

Structure. 2013 Aug 6;21(8):1307-16. doi: 10.1016/j.str.2013.06.018.

12.

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C.

J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507.

13.

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.

Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12143-8. doi: 10.1073/pnas.1104494108.

14.

Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel.

Laurent B, Murail S, Shahsavar A, Sauguet L, Delarue M, Baaden M.

Structure. 2016 Apr 5;24(4):595-605. doi: 10.1016/j.str.2016.02.014.

PMID:
27021161
15.

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.

Chen Q, Kinde MN, Arjunan P, Wells MM, Cohen AE, Xu Y, Tang P.

Sci Rep. 2015 Sep 8;5:13833. doi: 10.1038/srep13833.

16.

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.

Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12149-54. doi: 10.1073/pnas.1104480108.

17.

Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels.

Sauguet L, Shahsavar A, Delarue M.

Biochim Biophys Acta. 2015 Mar;1850(3):511-23. doi: 10.1016/j.bbagen.2014.05.007. Review.

PMID:
24836522
18.

Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.

Howard RJ, Trudell JR, Harris RA.

Pharmacol Rev. 2014 Feb 10;66(2):396-412. doi: 10.1124/pr.113.007468. Review.

19.

Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC).

Velisetty P, Chalamalasetti SV, Chakrapani S.

J Biol Chem. 2014 Jan 31;289(5):3013-25. doi: 10.1074/jbc.M113.523050.

20.

Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel.

Laha KT, Ghosh B, Czajkowski C.

PLoS One. 2013 Nov 19;8(11):e80322. doi: 10.1371/journal.pone.0080322.

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