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Items: 1 to 20 of 101


Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases.

Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL.

Blood. 2011 Mar 17;117(11):3087-95. doi: 10.1182/blood-2010-06-292219. Epub 2011 Jan 18.


Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.

Mason LH, Willette-Brown J, Taylor LS, McVicar DW.

J Immunol. 2006 Jun 1;176(11):6615-23.


Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation.

Colucci F, Turner M, Schweighoffer E, Guy-Grand D, Di Bartolo V, Salcedo M, Tybulewicz VL, Di Santo JP.

J Immunol. 1999 Aug 15;163(4):1769-74.


Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells.

Pisegna S, Zingoni A, Pirozzi G, Cinque B, Cifone MG, Morrone S, Piccoli M, Frati L, Palmieri G, Santoni A.

J Immunol. 2002 Jul 1;169(1):68-74.


Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.

Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7012-7. Epub 2006 Apr 20.


NKG2D triggers cytotoxicity in murine epidermal γδ T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway.

Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T.

J Invest Dermatol. 2014 Feb;134(2):396-404. doi: 10.1038/jid.2013.353. Epub 2013 Aug 20.


Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.

Colucci F, Schweighoffer E, Tomasello E, Turner M, Ortaldo JR, Vivier E, Tybulewicz VL, Di Santo JP.

Nat Immunol. 2002 Mar;3(3):288-94. Epub 2002 Feb 11.


Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.

Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW.

Blood. 2008 Oct 1;112(7):2869-77. doi: 10.1182/blood-2007-11-121590. Epub 2008 Jul 21.


Syk regulation of phosphoinositide 3-kinase-dependent NK cell function.

Jiang K, Zhong B, Gilvary DL, Corliss BC, Vivier E, Hong-Geller E, Wei S, Djeu JY.

J Immunol. 2002 Apr 1;168(7):3155-64.


Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells.

Ting AT, Dick CJ, Schoon RA, Karnitz LM, Abraham RT, Leibson PJ.

J Biol Chem. 1995 Jul 7;270(27):16415-21.


Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity.

Brumbaugh KM, Binstadt BA, Billadeau DD, Schoon RA, Dick CJ, Ten RM, Leibson PJ.

J Exp Med. 1997 Dec 15;186(12):1965-74.


2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.

Bida AT, Upshaw Neff JL, Dick CJ, Schoon RA, Brickshawana A, Chini CC, Billadeau DD.

Mol Immunol. 2011 May;48(9-10):1149-59. doi: 10.1016/j.molimm.2011.02.008. Epub 2011 Mar 25.


NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.

Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ.

Nat Immunol. 2003 Jun;4(6):557-64. Epub 2003 May 11.


CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment.

Rabot M, El Costa H, Polgar B, Marie-Cardine A, Aguerre-Girr M, Barakonyi A, Valitutti S, Bensussan A, Le Bouteiller P.

Int Immunol. 2007 Apr;19(4):401-9. Epub 2007 Feb 16.


NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F.

Nat Immunol. 2003 Jun;4(6):565-72. Epub 2003 May 11.


Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma.

Kondadasula SV, Roda JM, Parihar R, Yu J, Lehman A, Caligiuri MA, Tridandapani S, Burry RW, Carson WE 3rd.

Blood. 2008 Apr 15;111(8):4173-83. doi: 10.1182/blood-2007-01-068908. Epub 2008 Jan 3.


Protein tyrosine kinase Syk in mast cell signaling.

Siraganian RP, Zhang J, Suzuki K, Sada K.

Mol Immunol. 2002 Sep;38(16-18):1229-33. Review.


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