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Items: 1 to 20 of 92

1.

Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes.

Tupper J, Crompton MR, Harvey AJ.

Arch Dermatol Res. 2011 May;303(4):293-7. doi: 10.1007/s00403-010-1118-4. Epub 2011 Jan 15.

2.

Role of breast tumour kinase in the in vitro differentiation of HaCaT cells.

Wang TC, Jee SH, Tsai TF, Huang YL, Tsai WL, Chen RH.

Br J Dermatol. 2005 Aug;153(2):282-9.

PMID:
16086737
3.
4.

Breast tumor kinase/protein tyrosine kinase 6 (Brk/PTK6) activity in normal and neoplastic biliary epithelia.

Mizuguchi Y, Specht S, Isse K, Sasatomi E, Lunz JG 3rd, Takizawa T, Demetris AJ.

J Hepatol. 2015 Aug;63(2):399-407. doi: 10.1016/j.jhep.2015.02.047. Epub 2015 Mar 12.

PMID:
25770659
5.

Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.

Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z.

Oncogene. 2012 Oct 4;31(40):4372-83. doi: 10.1038/onc.2011.608. Epub 2012 Jan 9.

6.

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA.

Breast Cancer Res. 2011 Sep 17;13(5):R89. doi: 10.1186/bcr2946.

7.

Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.

Ai M, Liang K, Lu Y, Qiu S, Fan Z.

Cancer Biol Ther. 2013 Mar;14(3):237-45. doi: 10.4161/cbt.23295. Epub 2013 Jan 4.

8.

Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.

Brauer PM, Tyner AL.

Biochim Biophys Acta. 2010 Aug;1806(1):66-73. doi: 10.1016/j.bbcan.2010.02.003. Epub 2010 Feb 26. Review.

10.

HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.

Ai M, Qiu S, Lu Y, Fan Z.

Cell Signal. 2013 Sep;25(9):1754-61. doi: 10.1016/j.cellsig.2013.05.010. Epub 2013 May 22.

11.

Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.

Ludyga N, Anastasov N, Gonzalez-Vasconcellos I, Ram M, Höfler H, Aubele M.

Mol Biosyst. 2011 May;7(5):1603-12. doi: 10.1039/c0mb00286k. Epub 2011 Mar 4.

PMID:
21380407
12.

Brk/PTK6 signaling in normal and cancer cell models.

Ostrander JH, Daniel AR, Lange CA.

Curr Opin Pharmacol. 2010 Dec;10(6):662-9. doi: 10.1016/j.coph.2010.08.007. Epub 2010 Sep 9. Review.

13.

Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, Marzec M, Gimotty P, Crompton MR, Wasik MA.

Am J Pathol. 2006 May;168(5):1631-41.

14.

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Peng M, Emmadi R, Wang Z, Wiley EL, Gann PH, Khan SA, Banerji N, McDonald W, Asztalos S, Pham TN, Tonetti DA, Tyner AL.

Oncotarget. 2014 Aug 15;5(15):6038-48.

15.

The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis.

Haegebarth A, Nunez R, Tyner AL.

Cell Cycle. 2005 Sep;4(9):1239-46. Epub 2005 Sep 23.

PMID:
16082217
16.

The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary.

Schmandt RE, Bennett M, Clifford S, Thornton A, Jiang F, Broaddus RR, Sun CC, Lu KH, Sood AK, Gershenson DM.

Cancer Biol Ther. 2006 Sep;5(9):1136-41. Epub 2006 Sep 28.

PMID:
16855388
17.

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.

Lukong KE, Huot ME, Richard S.

Cell Signal. 2009 Sep;21(9):1415-22. doi: 10.1016/j.cellsig.2009.04.008. Epub 2009 May 9.

PMID:
19439179
18.

Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.

Tsui T, Miller WT.

Biochemistry. 2015 May 26;54(20):3173-82. doi: 10.1021/acs.biochem.5b00303. Epub 2015 May 13.

19.

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