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Items: 1 to 20 of 100

1.

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death.

Kucejova B, Sunny NE, Nguyen AD, Hallac R, Fu X, Peña-Llopis S, Mason RP, Deberardinis RJ, Xie XJ, Debose-Boyd R, Kodibagkar VD, Burgess SC, Brugarolas J.

Oncogene. 2011 May 5;30(18):2147-60. doi: 10.1038/onc.2010.587. Epub 2011 Jan 10.

3.

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ.

Nature. 1999 May 20;399(6733):271-5.

PMID:
10353251
5.

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH.

Mol Cell Biol. 2005 Apr;25(8):3163-72.

6.

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing.

Kaelin WG.

Cold Spring Harb Symp Quant Biol. 2005;70:159-66. Review.

PMID:
16869749
7.

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.

Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH.

Mol Cell Biol. 2009 Aug;29(16):4527-38. doi: 10.1128/MCB.00200-09. Epub 2009 Jun 15.

8.

Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein.

Mathia S, Paliege A, Koesters R, Peters H, Neumayer HH, Bachmann S, Rosenberger C.

Acta Physiol (Oxf). 2013 Mar;207(3):565-76. doi: 10.1111/apha.12058.

PMID:
23384425
9.

Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.

Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, Maher ER.

Cancer Res. 2002 Jul 1;62(13):3803-11. Erratum in: Cancer Res. 2015 Sep 15;75(18):3993.

11.

Identification of novel VHL target genes and relationship to hypoxic response pathways.

Maina EN, Morris MR, Zatyka M, Raval RR, Banks RE, Richards FM, Johnson CM, Maher ER.

Oncogene. 2005 Jun 30;24(28):4549-58.

PMID:
15824735
12.

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery.

Alcaide-German ML, Vara-Vega A, Garcia-Fernandez LF, Landazuri MO, del Peso L.

BMC Cell Biol. 2008 Apr 10;9:18. doi: 10.1186/1471-2121-9-18.

13.

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH.

J Biol Chem. 2000 Aug 18;275(33):25733-41.

14.

Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma.

Turcotte S, Desrosiers RR, Beliveau R.

Am J Physiol Renal Physiol. 2004 Feb;286(2):F338-48. Epub 2003 Oct 28.

15.
16.

Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner.

Kai S, Tanaka T, Daijo H, Harada H, Kishimoto S, Suzuki K, Takabuchi S, Takenaga K, Fukuda K, Hirota K.

Antioxid Redox Signal. 2012 Feb 1;16(3):203-16. doi: 10.1089/ars.2011.3882. Epub 2011 Oct 17.

17.

Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression.

Miró-Murillo M, Elorza A, Soro-Arnáiz I, Albacete-Albacete L, Ordoñez A, Balsa E, Vara-Vega A, Vázquez S, Fuertes E, Fernández-Criado C, Landázuri MO, Aragonés J.

PLoS One. 2011;6(7):e22589. doi: 10.1371/journal.pone.0022589. Epub 2011 Jul 21.

18.

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.

Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH.

Oncogene. 2008 Sep 11;27(40):5354-8. doi: 10.1038/onc.2008.160. Epub 2008 May 19.

19.

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.

Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM.

Hepatology. 2011 Aug;54(2):472-83. doi: 10.1002/hep.24400. Epub 2011 Jun 26.

20.

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.

Tanimoto K, Makino Y, Pereira T, Poellinger L.

EMBO J. 2000 Aug 15;19(16):4298-309.

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