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Items: 1 to 20 of 83

1.

Heparin exerts a dual effect on murine lupus nephritis by enhancing enzymatic chromatin degradation and preventing chromatin binding in glomerular membranes.

Hedberg A, Fismen S, Fenton KA, Fenton C, Osterud B, Mortensen ES, Rekvig OP.

Arthritis Rheum. 2011 Apr;63(4):1065-75. doi: 10.1002/art.30211.

2.

Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens.

Mjelle JE, Rekvig OP, Van Der Vlag J, Fenton KA.

Autoimmunity. 2011 Aug;44(5):373-83. doi: 10.3109/08916934.2010.541170. Epub 2011 Jan 19.

PMID:
21244336
3.

Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis.

Fismen S, Hedberg A, Fenton KA, Jacobsen S, Krarup E, Kamper AL, Rekvig OP, Mortensen ES.

Lupus. 2009 Jun;18(7):597-607. doi: 10.1177/0961203308100512.

PMID:
19433459
4.
5.

Reduced fragmentation of apoptotic chromatin is associated with nephritis in lupus-prone (NZB x NZW)F(1) mice.

Zykova SN, Seredkina N, Benjaminsen J, Rekvig OP.

Arthritis Rheum. 2008 Mar;58(3):813-25. doi: 10.1002/art.23276.

6.

Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities.

Hedberg A, Fismen S, Fenton KA, Mortensen ES, Rekvig OP.

Exp Dermatol. 2010 Aug;19(8):e265-74. doi: 10.1111/j.1600-0625.2010.01064.x.

7.

Nucleosomes and histones are present in glomerular deposits in human lupus nephritis.

van Bruggen MC, Kramers C, Walgreen B, Elema JD, Kallenberg CG, van den Born J, Smeenk RJ, Assmann KJ, Muller S, Monestier M, Berden JH.

Nephrol Dial Transplant. 1997 Jan;12(1):57-66.

PMID:
9027774
8.

Pathogenic mechanisms in lupus nephritis: Nucleosomes bind aberrant laminin β1 with high affinity and colocalize in the electron-dense deposits.

Olin AI, Mörgelin M, Truedsson L, Sturfelt G, Bengtsson AA.

Arthritis Rheumatol. 2014 Feb;66(2):397-406. doi: 10.1002/art.38250.

9.

Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis.

Grootscholten C, van Bruggen MC, van der Pijl JW, de Jong EM, Ligtenberg G, Derksen RH, Berden JH; Dutch Working Party on Systemic Lupus Erythematosus.

Arthritis Rheum. 2003 May;48(5):1355-62.

10.

Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus.

Fenton KA, Mjelle JE, Jakobsen S, Olsen R, Rekvig OP.

Mol Immunol. 2008 Jun;45(11):3117-24. doi: 10.1016/j.molimm.2008.03.001.

PMID:
18423862
11.
12.

Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes.

Mortensen ES, Rekvig OP.

J Am Soc Nephrol. 2009 Apr;20(4):696-704. doi: 10.1681/ASN.2008010112. Review.

13.

Glomerular expression of large polyomavirus T antigen in binary tet-off regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis.

Bendiksen S, Mortensen ES, Olsen R, Fenton KA, Kalaaji M, Jørgensen L, Rekvig OP.

Mol Immunol. 2008 Feb;45(3):728-39. Epub 2007 Aug 24.

PMID:
17719634
14.

Qualitative alterations in laminin expression in experimental lupus nephritis.

Kootstra CJ, Bergijk EC, Veninga A, Prins FA, de Heer E, Abrahamson DR, Bruijn JA.

Am J Pathol. 1995 Aug;147(2):476-88.

15.

Heparin and heparinoids prevent the binding of immune complexes containing nucleosomal antigens to the GBM and delay nephritis in MRL/lpr mice.

van Bruggen MC, Walgreen B, Rijke TP, Corsius MJ, Assmann KJ, Smeenk RJ, van Dedem GW, Kramers K, Berden JH.

Kidney Int. 1996 Nov;50(5):1555-64.

16.

Murine and Human Lupus Nephritis: Pathogenic Mechanisms and Theoretical Strategies for Therapy.

Pedersen HL, Horvei KD, Thiyagarajan D, Seredkina N, Rekvig OP.

Semin Nephrol. 2015 Sep;35(5):427-38. doi: 10.1016/j.semnephrol.2015.08.004. Review.

PMID:
26573545
17.

Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis.

Berden JH, Licht R, van Bruggen MC, Tax WJ.

Curr Opin Nephrol Hypertens. 1999 May;8(3):299-306. Review.

PMID:
10456260
18.

Autoimmunity against nucleosomes and lupus nephritis.

Van Bruggen MC, Kramers C, Berden JH.

Ann Med Interne (Paris). 1996;147(7):485-9. Review.

PMID:
9092359
19.

Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis.

Kalaaji M, Sturfelt G, Mjelle JE, Nossent H, Rekvig OP.

Arthritis Rheum. 2006 Mar;54(3):914-26.

20.

Lupus nephritis: Nucleosomes trapped by aberrantly expressed laminin-β1.

Jones B.

Nat Rev Nephrol. 2014 Jan;10(1):4. doi: 10.1038/nrneph.2013.246. Epub 2013 Nov 19. No abstract available.

PMID:
24247286

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