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Items: 1 to 20 of 93


Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer.

Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H.

Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.


Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002.

Kunnimalaiyaan M, Ndiaye M, Chen H.

Surgery. 2006 Dec;140(6):1009-14; discussion 1014-5. Epub 2006 Nov 1.


MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition.

Burke JF, Schlosser L, Harrison AD, Kunnimalaiyaan M, Chen H.

Ann Surg Oncol. 2013 Nov;20(12):3862-8. doi: 10.1245/s10434-013-3168-2. Epub 2013 Jul 31.


Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.

Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H.

Ann Surg Oncol. 2008 Sep;15(9):2600-5. doi: 10.1245/s10434-008-0006-z. Epub 2008 Jun 18.


Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.

Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H.

Oncologist. 2008 Feb;13(2):98-104. doi: 10.1634/theoncologist.2007-0190.


Chrysin suppresses achaete-scute complex-like 1 and alters the neuroendocrine phenotype of carcinoids.

Somnay YR, Dull BZ, Eide J, Jaskula-Sztul R, Chen H.

Cancer Gene Ther. 2015 Oct;22(10):496-505. doi: 10.1038/cgt.2015.49. Epub 2015 Sep 25.


Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells.

Greenblatt DY, Cayo MA, Adler JT, Ning L, Haymart MR, Kunnimalaiyaan M, Chen H.

Ann Surg. 2008 Jun;247(6):1036-40. doi: 10.1097/SLA.0b013e3181758d0e.


Leflunomide suppresses growth in human medullary thyroid cancer cells.

Alhefdhi A, Burke JF, Redlich A, Kunnimalaiyaan M, Chen H.

J Surg Res. 2013 Nov;185(1):212-6. doi: 10.1016/j.jss.2013.05.089. Epub 2013 Jun 19.


Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells.

Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H.

J Biol Chem. 2006 Dec 29;281(52):39819-30. Epub 2006 Nov 7.


MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype.

Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H.

J Surg Res. 2010 Jan;158(1):15-9. doi: 10.1016/j.jss.2009.05.032.


Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer.

Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M.

Am J Surg. 2010 Mar;199(3):315-8; discussion 318. doi: 10.1016/j.amjsurg.2009.08.034.


Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.

Tesfazghi S, Eide J, Dammalapati A, Korlesky C, Wyche TP, Bugni TS, Chen H, Jaskula-Sztul R.

Cancer Med. 2013 Oct;2(5):734-43. doi: 10.1002/cam4.118. Epub 2013 Sep 17.


Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells.

Rinner B, Li ZX, Haas H, Siegl V, Sturm S, Stuppner H, Pfragner R.

Anticancer Res. 2009 Nov;29(11):4519-28.


Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro.

Somnay Y, Chen H, Kunnimalaiyaan M.

Neuroendocrinology. 2013;97(2):183-92. doi: 10.1159/000341810. Epub 2012 Sep 4.


Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells.

Du ZX, Zhang HY, Gao DX, Wang HQ, Li YJ, Liu GL.

Exp Mol Med. 2006 Jun 30;38(3):230-40.


Expression of the active Notch1 decreases MTC tumor growth in vivo.

Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M.

J Surg Res. 2011 Nov;171(1):23-7. doi: 10.1016/j.jss.2011.03.035. Epub 2011 Apr 13.


The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.

Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H.

Surgery. 2003 Dec;134(6):866-71; discussion 871-3.


Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations.

de Groot JW, Plaza Menacho I, Schepers H, Drenth-Diephuis LJ, Osinga J, Plukker JT, Links TP, Eggen BJ, Hofstra RM.

Surgery. 2006 Jun;139(6):806-14.


Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo.

Yu XM, Phan T, Patel PN, Jaskula-Sztul R, Chen H.

Cancer. 2013 Feb 15;119(4):774-81. doi: 10.1002/cncr.27742. Epub 2012 Sep 18.


Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta.

Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H.

Mol Cancer Ther. 2009 Apr;8(4):914-20. doi: 10.1158/1535-7163.MCT-08-0712. Erratum in: Mol Cancer Ther. 2010 May;9(5):1482.

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