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Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism.

Oosting M, van de Veerdonk FL, Kanneganti TD, Sturm P, Verschueren I, Berende A, van der Meer JW, Kullberg BJ, Netea MG, Joosten LA.

Eur J Immunol. 2011 Jan;41(1):172-81. doi: 10.1002/eji.201040385.


Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.

Oosting M, Buffen K, Malireddi SR, Sturm P, Verschueren I, Koenders MI, van de Veerdonk FL, van der Meer JW, Netea MG, Kanneganti TD, Joosten LA.

Arthritis Res Ther. 2012 Nov 13;14(6):R247. doi: 10.1186/ar4090.


The caspase 1 inflammasome is not required for control of murine Lyme borreliosis.

Liu N, Belperron AA, Booth CJ, Bockenstedt LK.

Infect Immun. 2009 Aug;77(8):3320-7. doi: 10.1128/IAI.00100-09.


MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi.

Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ.

PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212.


Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis.

Hansen ES, Medić V, Kuo J, Warner TF, Schell RF, Nardelli DT.

Infect Immun. 2013 Dec;81(12):4421-30. doi: 10.1128/IAI.01129-13.


Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis.

Gonçalves AC, Maia DC, Ferreira LS, Monnazzi LG, Alegranci P, Placeres MC, Batista-Duharte A, Carlos IZ.

Mycopathologia. 2015 Feb;179(1-2):21-30. doi: 10.1007/s11046-014-9810-0.


Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response.

Craig-Mylius K, Weber GF, Coburn J, Glickstein L.

J Leukoc Biol. 2005 May;77(5):710-8.


Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice.

Belperron AA, Liu N, Booth CJ, Bockenstedt LK.

Front Cell Infect Microbiol. 2014 Jun 11;4:75. doi: 10.3389/fcimb.2014.00075.


CD4+ cell-derived interleukin-17 in a model of dysregulated, Borrelia-induced arthritis.

Hansen ES, Johnson ME, Schell RF, Nardelli DT.

Pathog Dis. 2016 Oct;74(7). pii: ftw084. doi: 10.1093/femspd/ftw084.


T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17.

Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, Helsen MM, van den Bersselaar LA, Oppers-Walgreen B, Koenders MI, van den Berg WB.

Arthritis Rheum. 2008 Jan;58(1):98-108. doi: 10.1002/art.23152.


Antagonistic effect of the inflammasome on thymic stromal lymphopoietin expression in the skin.

Schuepbach-Mallepell S, Philippe V, Brüggen MC, Watanabe H, Roques S, Baldeschi C, Gaide O.

J Allergy Clin Immunol. 2013 Dec;132(6):1348-57. doi: 10.1016/j.jaci.2013.06.033.


Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β.

Angosto D, López-Castejón G, López-Muñoz A, Sepulcre MP, Arizcun M, Meseguer J, Mulero V.

Innate Immun. 2012 Dec;18(6):815-24. doi: 10.1177/1753425912441956.


Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection.

Lee BH, Hwang DM, Palaniyar N, Grinstein S, Philpott DJ, Hu J.

PLoS One. 2012;7(4):e35812. doi: 10.1371/journal.pone.0035812.


Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi.

Potter MR, Rittling SR, Denhardt DT, Roper RJ, Weis JH, Teuscher C, Weis JJ.

Infect Immun. 2002 Mar;70(3):1372-81.


Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis.

Codolo G, Amedei A, Steere AC, Papinutto E, Cappon A, Polenghi A, Benagiano M, Paccani SR, Sambri V, Del Prete G, Baldari CT, Zanotti G, Montecucco C, D'Elios MM, de Bernard M.

Arthritis Rheum. 2008 Nov;58(11):3609-17. doi: 10.1002/art.23972.


Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-γ-mediated Lyme arthritis.

Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Spangrude GJ, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2012 Feb 1;188(3):1381-93. doi: 10.4049/jimmunol.1102359.


Interleukin-4-deficient BALB/c mice develop an enhanced Th1-like response but control cardiac inflammation following Borrelia burgdorferi infection.

Satoskar AR, Elizondo J, Monteforte GM, Stamm LM, Bluethmann H, Katavolos P, Telford SR 3rd.

FEMS Microbiol Lett. 2000 Feb 15;183(2):319-25.


Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15.

Gov L, Karimzadeh A, Ueno N, Lodoen MB.

MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13.


Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense.

Brown JP, Zachary JF, Teuscher C, Weis JJ, Wooten RM.

Infect Immun. 1999 Oct;67(10):5142-50.

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