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Co-conserved features associated with cis regulation of ErbB tyrosine kinases.

Mirza A, Mustafa M, Talevich E, Kannan N.

PLoS One. 2010 Dec 13;5(12):e14310. doi: 10.1371/journal.pone.0014310.


Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: a molecular dynamics study.

Mustafa M, Mirza A, Kannan N.

Proteins. 2011 Jan;79(1):99-114. doi: 10.1002/prot.22862. Epub 2010 Oct 11.


Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation.

Thiel KW, Carpenter G.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19238-43. Epub 2007 Nov 27.


Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006265.


The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.

Kannan N, Haste N, Taylor SS, Neuwald AF.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1272-7. Epub 2007 Jan 16. Erratum in: Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9130.


Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers.

Yen L, Benlimame N, Nie ZR, Xiao D, Wang T, Al Moustafa AE, Esumi H, Milanini J, Hynes NE, Pages G, Alaoui-Jamali MA.

Mol Biol Cell. 2002 Nov;13(11):4029-44.


The ErbB/HER receptor protein-tyrosine kinases and cancer.

Roskoski R Jr.

Biochem Biophys Res Commun. 2004 Jun 18;319(1):1-11. Review.


Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.

Nguyen T, Ruan Z, Oruganty K, Kannan N.

PLoS One. 2015 Mar 23;10(3):e0119636. doi: 10.1371/journal.pone.0119636. eCollection 2015.


Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases.

Shih AJ, Telesco SE, Choi SH, Lemmon MA, Radhakrishnan R.

Biochem J. 2011 Jun 1;436(2):241-51. doi: 10.1042/BJ20101791.


An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.

Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J.

Cell. 2006 Jun 16;125(6):1137-49.


The single transmembrane domains of ErbB receptors self-associate in cell membranes.

Mendrola JM, Berger MB, King MC, Lemmon MA.

J Biol Chem. 2002 Feb 15;277(7):4704-12. Epub 2001 Dec 10.


Protein kinases share a common structural motif outside the conserved catalytic domain.

VĂ©ron M, Radzio-Andzelm E, Tsigelny I, Taylor S.

Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):587-96. Review.


Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.

Monsey J, Shen W, Schlesinger P, Bose R.

J Biol Chem. 2010 Mar 5;285(10):7035-44. doi: 10.1074/jbc.M109.096032. Epub 2009 Dec 18.


Structure-function analysis of nucleolin and ErbB receptors interactions.

Farin K, Di Segni A, Mor A, Pinkas-Kramarski R.

PLoS One. 2009 Jul 3;4(7):e6128. doi: 10.1371/journal.pone.0006128.


Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation.

Contessa JN, Abell A, Mikkelsen RB, Valerie K, Schmidt-Ullrich RK.

Breast Cancer Res Treat. 2006 Jan;95(1):17-27.


Evolutionary analysis of the ErbB receptor and ligand families.

Stein RA, Staros JV.

J Mol Evol. 2000 May;50(5):397-412.


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