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The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier.

Sturm OE, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B, Kolch W.

Sci Signal. 2010 Dec 21;3(153):ra90. doi: 10.1126/scisignal.2001212.


Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway.

Shin SY, Rath O, Choo SM, Fee F, McFerran B, Kolch W, Cho KH.

J Cell Sci. 2009 Feb 1;122(Pt 3):425-35. doi: 10.1242/jcs.036319.


Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

Cirit M, Wang CC, Haugh JM.

J Biol Chem. 2010 Nov 19;285(47):36736-44. doi: 10.1074/jbc.M110.148759. Epub 2010 Sep 16.


Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3.


Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway.

Adler V, Qu Y, Smith SJ, Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR.

Biochemistry. 2005 Aug 16;44(32):10784-95.


CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells.

Arai A, Aoki M, Weihua Y, Jin A, Miura O.

Cell Signal. 2006 Dec;18(12):2162-71. Epub 2006 May 16.


Spatio-temporal dynamics of a cell signal pathway with negative feedbacks: the MAPK/ERK pathway.

Maya-Bernal JL, Ramírez-Santiago G.

Eur Phys J E Soft Matter. 2016 Mar;39(3):28. doi: 10.1140/epje/i2016-16028-3. Epub 2016 Mar 21.


Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.

Li DW, Liu JP, Mao YW, Xiang H, Wang J, Ma WY, Dong Z, Pike HM, Brown RE, Reed JC.

Mol Biol Cell. 2005 Sep;16(9):4437-53. Epub 2005 Jul 6.


SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.

Dong Chen, Waters SB, Holt KH, Pessin JE.

J Biol Chem. 1996 Mar 15;271(11):6328-32.


Processive phosphorylation of ERK MAP kinase in mammalian cells.

Aoki K, Yamada M, Kunida K, Yasuda S, Matsuda M.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12675-80. doi: 10.1073/pnas.1104030108. Epub 2011 Jul 18.


c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.

Iijima Y, Laser M, Shiraishi H, Willey CD, Sundaravadivel B, Xu L, McDermott PJ, Kuppuswamy D.

J Biol Chem. 2002 Jun 21;277(25):23065-75. Epub 2002 Apr 8.


Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.

Unni E, Sun S, Nan B, McPhaul MJ, Cheskis B, Mancini MA, Marcelli M.

Cancer Res. 2004 Oct 1;64(19):7156-68.


Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Kiel C, Serrano L.

Sci Signal. 2009 Jul 28;2(81):ra38. doi: 10.1126/scisignal.2000397.

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