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Detrimental effects of adenosine signaling in sickle cell disease.

Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y.

Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19.


Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.

Sun K, Zhang Y, Bogdanov MV, Wu H, Song A, Li J, Dowhan W, Idowu M, Juneja HS, Molina JG, Blackburn MR, Kellems RE, Xia Y.

Blood. 2015 Mar 5;125(10):1643-52. doi: 10.1182/blood-2014-08-595751. Epub 2015 Jan 13.


Adenosine signaling in normal and sickle erythrocytes and beyond.

Zhang Y, Xia Y.

Microbes Infect. 2012 Aug;14(10):863-73. doi: 10.1016/j.micinf.2012.05.005. Epub 2012 May 23. Review.


Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression.

Ning C, Wen J, Zhang Y, Dai Y, Wang W, Zhang W, Qi L, Grenz A, Eltzschig HK, Blackburn MR, Kellems RE, Xia Y.

FASEB J. 2014 Jun;28(6):2725-35. doi: 10.1096/fj.13-247833. Epub 2014 Mar 10.


New insights into sickle cell disease: a disease of hypoxia.

Sun K, Xia Y.

Curr Opin Hematol. 2013 May;20(3):215-21. doi: 10.1097/MOH.0b013e32835f55f9. Review.


Adenosine receptor crossroads in sickle cell disease.

Gladwin MT.

Nat Med. 2011 Jan;17(1):38-40. doi: 10.1038/nm0111-38. No abstract available.


The role of adenosine signaling in sickle cell therapeutics.

Field JJ, Nathan DG, Linden J.

Hematol Oncol Clin North Am. 2014 Apr;28(2):287-99. doi: 10.1016/j.hoc.2013.11.003. Epub 2014 Jan 18. Review. Erratum in: Hematol Oncol Clin North Am. 2015 Apr;29(2):xv.


Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

Circulation. 2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311.


Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.

Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y.

J Clin Invest. 2014 Jun;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16.


Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice.

Dasgupta T, Fabry ME, Kaul DK.

Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R394-402. doi: 10.1152/ajpregu.00611.2009. Epub 2009 Dec 9.


Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling.

Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, Xia Y.

J Clin Invest. 2008 Apr;118(4):1491-501. doi: 10.1172/JCI33467.


A2B adenosine receptor-mediated induction of IL-6 promotes CKD.

Dai Y, Zhang W, Wen J, Zhang Y, Kellems RE, Xia Y.

J Am Soc Nephrol. 2011 May;22(5):890-901. doi: 10.1681/ASN.2010080890. Epub 2011 Apr 21.


Adenosine signaling, priapism and novel therapies.

Dai Y, Zhang Y, Phatarpekar P, Mi T, Zhang H, Blackburn MR, Xia Y.

J Sex Med. 2009 Mar;6 Suppl 3:292-301. doi: 10.1111/j.1743-6109.2008.01187.x. Review.


Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling.

Wen J, Jiang X, Dai Y, Zhang Y, Tang Y, Sun H, Mi T, Phatarpekar PV, Kellems RE, Blackburn MR, Xia Y.

FASEB J. 2010 Mar;24(3):740-9. doi: 10.1096/fj.09-144147. Epub 2009 Oct 26.


Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia.

Ataga KI, Stocker J.

Expert Opin Investig Drugs. 2009 Feb;18(2):231-9. doi: 10.1517/13543780802708011 . Review.


Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model.

Tan F, Ghosh S, Mosunjac M, Manci E, Ofori-Acquah SF.

Exp Biol Med (Maywood). 2016 Apr;241(7):766-71. doi: 10.1177/1535370216642046. Epub 2016 Mar 29.


High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia.

Fabry ME, Costantini F, Pachnis A, Suzuka SM, Bank N, Aynedjian HS, Factor SM, Nagel RL.

Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12155-9.


Second generation knockout sickle mice: the effect of HbF.

Fabry ME, Suzuka SM, Weinberg RS, Lawrence C, Factor SM, Gilman JG, Costantini F, Nagel RL.

Blood. 2001 Jan 15;97(2):410-8.


Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor.

Zhou Y, Mohsenin A, Morschl E, Young HW, Molina JG, Ma W, Sun CX, Martinez-Valdez H, Blackburn MR.

J Immunol. 2009 Jun 15;182(12):8037-46. doi: 10.4049/jimmunol.0900515.

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