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Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.

Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR.

Biochemistry. 2011 Feb 8;50(5):752-62. doi: 10.1021/bi101910n. Epub 2011 Jan 11.


G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.

Vellano CP, Maher EM, Hepler JR, Blumer JB.

J Biol Chem. 2011 Nov 4;286(44):38659-69. doi: 10.1074/jbc.M111.274928. Epub 2011 Aug 31.


The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.

Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR.

PLoS One. 2011;6(8):e23197. doi: 10.1371/journal.pone.0023197. Epub 2011 Aug 11.


Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).

Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR.

J Biol Chem. 2015 Apr 3;290(14):9037-49. doi: 10.1074/jbc.M114.634329. Epub 2015 Feb 9.


Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.

Vellano CP, Brown NE, Blumer JB, Hepler JR.

J Biol Chem. 2013 Feb 1;288(5):3620-31. doi: 10.1074/jbc.M112.440057. Epub 2012 Dec 17.


Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.

Thomas CJ, Tall GG, Adhikari A, Sprang SR.

J Biol Chem. 2008 Aug 22;283(34):23150-60. doi: 10.1074/jbc.M802422200. Epub 2008 Jun 9.


The RGS14 GoLoco domain discriminates among Galphai isoforms.

Mittal V, Linder ME.

J Biol Chem. 2004 Nov 5;279(45):46772-8. Epub 2004 Aug 26.


The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling.

Traver S, Splingard A, Gaudriault G, De Gunzburg J.

Biochem J. 2004 May 1;379(Pt 3):627-32.


Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).

Tse MK, Morris CJ, Zhang M, Wong YH.

Mol Cell Biochem. 2015 Mar;401(1-2):27-38. doi: 10.1007/s11010-014-2289-7. Epub 2014 Dec 6.


Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.

Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM.

J Biol Chem. 2013 Feb 1;288(5):3003-15. doi: 10.1074/jbc.M112.418467. Epub 2012 Dec 4.


Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.

Hollinger S, Ramineni S, Hepler JR.

Biochemistry. 2003 Jan 28;42(3):811-9.


RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP.

J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.


RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.

Shu FJ, Ramineni S, Hepler JR.

Cell Signal. 2010 Mar;22(3):366-76. doi: 10.1016/j.cellsig.2009.10.005.


Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.

Black LA, Thomas CJ, Nix GN, Terwilliger MC, Sprang SR, Ross JB.

Biophys J. 2016 Aug 23;111(4):722-31. doi: 10.1016/j.bpj.2016.07.021.


RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain.

Hollinger S, Taylor JB, Goldman EH, Hepler JR.

J Neurochem. 2001 Dec;79(5):941-9.


Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.

Chan P, Gabay M, Wright FA, Tall GG.

J Biol Chem. 2011 Jun 3;286(22):19932-42. doi: 10.1074/jbc.M110.163675. Epub 2011 Apr 5.


The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.

Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P.

J Cell Biochem. 2013 Jun;114(6):1414-23. doi: 10.1002/jcb.24483.


RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells.

Brown NE, Lambert NA, Hepler JR.

Pharmacol Res Perspect. 2016 Aug 18;4(5):e00249. eCollection 2016 Oct.


Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.

Woodard GE, Huang NN, Cho H, Miki T, Tall GG, Kehrl JH.

Mol Cell Biol. 2010 Jul;30(14):3519-30. doi: 10.1128/MCB.00394-10. Epub 2010 May 17.

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