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Items: 1 to 20 of 106

1.

Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.

MacFarlane AJ, Perry CA, McEntee MF, Lin DM, Stover PJ.

Carcinogenesis. 2011 Mar;32(3):427-33. doi: 10.1093/carcin/bgq270.

2.

Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.

Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ.

Am J Clin Nutr. 2012 Apr;95(4):882-91. doi: 10.3945/ajcn.111.030783.

3.

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.

Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R.

Hum Mol Genet. 2013 Sep 15;22(18):3705-19. doi: 10.1093/hmg/ddt223.

PMID:
23704330
4.

Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.

Field MS, Kamynina E, Agunloye OC, Liebenthal RP, Lamarre SG, Brosnan ME, Brosnan JT, Stover PJ.

J Biol Chem. 2014 Oct 24;289(43):29642-50. doi: 10.1074/jbc.M114.599589.

5.

MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.

Christensen KE, Deng L, Bahous RH, Jerome-Majewska LA, Rozen R.

Birth Defects Res A Clin Mol Teratol. 2015 Dec;103(12):1031-8. doi: 10.1002/bdra.23451.

PMID:
26408344
6.

Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.

MacFarlane AJ, McEntee MF, Stover PJ.

J Nutr. 2014 Apr;144(4):419-24. doi: 10.3945/jn.113.186007.

7.

Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.

Ma DW, Finnell RH, Davidson LA, Callaway ES, Spiegelstein O, Piedrahita JA, Salbaum JM, Kappen C, Weeks BR, James J, Bozinov D, Lupton JR, Chapkin RS.

Cancer Res. 2005 Feb 1;65(3):887-97.

8.

Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.

Macfarlane AJ, Perry CA, McEntee MF, Lin DM, Stover PJ.

Cancer Res. 2011 Mar 15;71(6):2098-107. doi: 10.1158/0008-5472.CAN-10-1886.

9.

Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.

Knock E, Deng L, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R.

J Nutr Biochem. 2011 Nov;22(11):1022-9. doi: 10.1016/j.jnutbio.2010.07.015.

PMID:
21193302
10.

Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos.

Pike ST, Rajendra R, Artzt K, Appling DR.

J Biol Chem. 2010 Feb 12;285(7):4612-20. doi: 10.1074/jbc.M109.079855.

11.

Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ.

J Biol Chem. 2009 Jan 16;284(3):1533-9. doi: 10.1074/jbc.M808281200.

13.

Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.

Derry MM, Raina K, Balaiya V, Jain AK, Shrotriya S, Huber KM, Serkova NJ, Agarwal R, Agarwal C.

Cancer Prev Res (Phila). 2013 Jul;6(7):625-33. doi: 10.1158/1940-6207.CAPR-13-0053.

14.

Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation.

Suzui M, Okuno M, Tanaka T, Nakagama H, Moriwaki H.

Cancer Lett. 2002 Sep 8;183(1):31-41.

PMID:
12049812
15.

Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.

Field MS, Shields KS, Abarinov EV, Malysheva OV, Allen RH, Stabler SP, Ash JA, Strupp BJ, Stover PJ, Caudill MA.

J Nutr. 2013 Jan;143(1):41-5. doi: 10.3945/jn.112.169821.

16.

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.

Field MS, Kamynina E, Watkins D, Rosenblatt DS, Stover PJ.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):400-5. doi: 10.1073/pnas.1414555112.

18.
19.

Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer.

Volate SR, Muga SJ, Issa AY, Nitcheva D, Smith T, Wargovich MJ.

Mol Carcinog. 2009 Oct;48(10):920-33. doi: 10.1002/mc.20542.

20.

A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss.

Parle-McDermott A, Pangilinan F, Mills JL, Signore CC, Molloy AM, Cotter A, Conley M, Cox C, Kirke PN, Scott JM, Brody LC.

Mol Hum Reprod. 2005 Jul;11(7):477-80.

PMID:
16123074

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