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The substrates of Plk1, beyond the functions in mitosis.

Liu XS, Song B, Liu X.

Protein Cell. 2010 Nov;1(11):999-1010. doi: 10.1007/s13238-010-0131-x. Epub 2010 Dec 10. Review.


Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.


Polo-like kinase-1 in DNA damage response.

Hyun SY, Hwang HI, Jang YJ.

BMB Rep. 2014 May;47(5):249-55. Review. Erratum in: BMB Rep. 2014 Jun;47(6):360. Hwan Hyo-In [corrected to Hwang Hyo-In].


Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.

Takaki T, Trenz K, Costanzo V, Petronczki M.

Curr Opin Cell Biol. 2008 Dec;20(6):650-60. doi: 10.1016/ Epub 2008 Nov 27. Review.


Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?

Archambault V, Carmena M.

Cell Cycle. 2012 Apr 15;11(8):1490-5. doi: 10.4161/cc.19724. Epub 2012 Apr 15.


Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.

Yim H, Erikson RL.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19742-7. doi: 10.1073/pnas.1013557107. Epub 2010 Nov 1.


The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2.

Tsvetkov LM, Tsekova RT, Xu X, Stern DF.

Cell Cycle. 2005 Apr;4(4):609-17. Epub 2005 Apr 9.


Identification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and Polo box-mediated interactions.

Bibi N, Parveen Z, Rashid S.

PLoS One. 2013 Aug 15;8(8):e70843. doi: 10.1371/journal.pone.0070843. eCollection 2013.


Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.

Liu XS, Li H, Song B, Liu X.

EMBO Rep. 2010 Aug;11(8):626-32. doi: 10.1038/embor.2010.90. Epub 2010 Jun 25.


P21-activated kinase is required for mitotic progression and regulates Plk1.

Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG.

Oncogene. 2008 Aug 21;27(36):4900-8. doi: 10.1038/onc.2008.131. Epub 2008 Apr 21.


Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy.

Studach L, Wang WH, Weber G, Tang J, Hullinger RL, Malbrue R, Liu X, Andrisani O.

J Biol Chem. 2010 Sep 24;285(39):30282-93. doi: 10.1074/jbc.M109.093963. Epub 2010 Jul 12.


The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1.

Ritter A, Sanhaji M, Steinhäuser K, Roth S, Louwen F, Yuan J.

Oncotarget. 2015 Mar 30;6(9):6641-55.


Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.

Lee HJ, Hwang HI, Jang YJ.

Cell Cycle. 2010 Jun 15;9(12):2389-98. Epub 2010 Jun 15.


Playing polo during mitosis: PLK1 takes the lead.

Combes G, Alharbi I, Braga LG, Elowe S.

Oncogene. 2017 Aug 24;36(34):4819-4827. doi: 10.1038/onc.2017.113. Epub 2017 Apr 24. Review.


High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.

Lera RF, Burkard ME.

J Biol Chem. 2012 Dec 14;287(51):42812-25. doi: 10.1074/jbc.M112.412544. Epub 2012 Oct 27.


Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.

Liu XS, Song B, Tang J, Liu W, Kuang S, Liu X.

Mol Cell Biol. 2012 Oct;32(19):4053-67. doi: 10.1128/MCB.00516-12. Epub 2012 Aug 6.


Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

Petronczki M, Lénárt P, Peters JM.

Dev Cell. 2008 May;14(5):646-59. doi: 10.1016/j.devcel.2008.04.014. Review.


Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.

Jang YJ, Ji JH, Choi YC, Ryu CJ, Ko SY.

J Biol Chem. 2007 Jan 26;282(4):2473-82. Epub 2006 Nov 22.


Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.

Song B, Liu XS, Davis K, Liu X.

Mol Cell Biol. 2011 Dec;31(23):4844-56. doi: 10.1128/MCB.06110-11. Epub 2011 Sep 26.


Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development.

Luo J, Liu X.

Protein Cell. 2012 Mar;3(3):182-97. doi: 10.1007/s13238-012-2020-y. Epub 2012 Mar 23. Review.

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