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Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.

Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S25. doi: 10.1186/1471-2164-11-S4-S25.


Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A.

Grover A, Shandilya A, Agrawal V, Pratik P, Bhasme D, Bisaria VS, Sundar D.

BMC Bioinformatics. 2011 Feb 15;12 Suppl 1:S30. doi: 10.1186/1471-2105-12-S1-S30.


Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes.

Grover A, Shandilya A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S15. doi: 10.1186/1471-2164-11-S4-S15.


Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.

Heyninck K, Lahtela-Kakkonen M, Van der Veken P, Haegeman G, Vanden Berghe W.

Biochem Pharmacol. 2014 Oct 15;91(4):501-9. doi: 10.1016/j.bcp.2014.08.004. Epub 2014 Aug 23.


Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages.

De Falco F, Di Giovanni C, Cerchia C, De Stefano D, Capuozzo A, Irace C, Iuvone T, Santamaria R, Carnuccio R, Lavecchia A.

Biochem Pharmacol. 2016 Mar 15;104:83-94. doi: 10.1016/j.bcp.2016.01.008. Epub 2016 Jan 14.


Thiol dependent NF-κB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A.

Gambhir L, Checker R, Sharma D, Thoh M, Patil A, Degani M, Gota V, Sandur SK.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):297-312. doi: 10.1016/j.taap.2015.09.014. Epub 2015 Sep 25.


Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling.

Jackson SS, Oberley C, Hooper CP, Grindle K, Wuerzberger-Davis S, Wolff J, McCool K, Rui L, Miyamoto S.

Exp Cell Res. 2015 Feb 1;331(1):58-72. doi: 10.1016/j.yexcr.2014.09.034. Epub 2014 Oct 7.


NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.

Solt LA, Madge LA, May MJ.

J Biol Chem. 2009 Oct 2;284(40):27596-608. doi: 10.1074/jbc.M109.047563. Epub 2009 Aug 7.


Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.


Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

Kaileh M, Vanden Berghe W, Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T, Haegeman G.

J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.


Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.

Patil KR, Mohapatra P, Patel HM, Goyal SN, Ojha S, Kundu CN, Patil CR.

PLoS One. 2015 May 4;10(5):e0125709. doi: 10.1371/journal.pone.0125709. eCollection 2015.


Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.

Solt LA, Madge LA, Orange JS, May MJ.

J Biol Chem. 2007 Mar 23;282(12):8724-33. Epub 2007 Jan 23.


Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.

Yong Y, Choi SW, Choi HJ, Nam HW, Kim JA, Jeong DU, Kim DY, Kim YS, Kim DW.

Mol Cell Biol. 2011 Jul;31(14):2802-16. doi: 10.1128/MCB.00253-10. Epub 2011 May 23.


Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation.

Su J, Zhao P, Kong L, Li X, Yan J, Zeng Y, Li Y.

PLoS One. 2013 Aug 1;8(8):e71333. doi: 10.1371/journal.pone.0071333. Print 2013.


Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.

Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB.

Cancer Res. 2008 Jul 1;68(13):5370-9. doi: 10.1158/0008-5472.CAN-08-0511.


Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis.

Jin HR, Jin SZ, Cai XF, Li D, Wu X, Nan JX, Lee JJ, Jin X.

PLoS One. 2012;7(6):e40355. doi: 10.1371/journal.pone.0040355. Epub 2012 Jun 29.


IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.

Adli M, Merkhofer E, Cogswell P, Baldwin AS.

PLoS One. 2010 Feb 25;5(2):e9428. doi: 10.1371/journal.pone.0009428.


Molecular docking and dynamic simulation studies evidenced plausible immunotherapeutic anticancer property by Withaferin A targeting indoleamine 2,3-dioxygenase.

Reddy SV, Reddy KT, Kumari VV, Basha SH.

J Biomol Struct Dyn. 2015;33(12):2695-709. doi: 10.1080/07391102.2015.1004834. Epub 2015 Feb 11.


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