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Items: 1 to 20 of 66

1.

And four equals one: presenilin takes the gamma-secretase role by itself.

Lessard CB, Wagner SL, Koo EH.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21236-7. doi: 10.1073/pnas.1016284108. Epub 2010 Dec 6. No abstract available.

2.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Fukumori A, Fluhrer R, Steiner H, Haass C.

J Neurosci. 2010 Jun 9;30(23):7853-62. doi: 10.1523/JNEUROSCI.1443-10.2010.

3.

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H.

J Neurochem. 2013 Apr;125(1):144-56. doi: 10.1111/jnc.12124. Epub 2013 Jan 15.

4.

Dissecting γ-secretase function.

Chávez-Gutiérrez L.

J Neurochem. 2013 Apr;125(1):1-3. doi: 10.1111/jnc.12077. No abstract available.

5.

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.

Neurobiol Dis. 2007 Jul;27(1):102-7. Epub 2007 May 6.

PMID:
17560791
6.

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J.

Physiol Behav. 2007 Sep 10;92(1-2):115-20. Epub 2007 May 21. Review.

PMID:
17588625
7.

Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.

Boo JH, Sohn JH, Kim JE, Song H, Mook-Jung I.

Biochem Biophys Res Commun. 2008 Aug 8;372(4):913-7. doi: 10.1016/j.bbrc.2008.05.153. Epub 2008 Jun 5.

PMID:
18538664
8.

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.

Pérez-Revuelta BI, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H.

J Neurochem. 2010 Feb;112(4):940-50. doi: 10.1111/j.1471-4159.2009.06510.x. Epub 2009 Dec 15.

9.

Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro.

Hatchett CS, Tyler S, Armstrong D, Dawbarn D, Allen SJ.

Brain Res. 2007 May 25;1147:248-55. Epub 2007 Feb 7.

PMID:
17349981
10.

Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease.

Golde TE, Ran Y, Felsenstein KM.

EMBO J. 2012 May 16;31(10):2237-9. doi: 10.1038/emboj.2012.111. Epub 2012 Apr 13. No abstract available.

11.

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B.

Nat Cell Biol. 2000 Jul;2(7):461-2. No abstract available.

PMID:
10878813
12.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
13.

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Cacquevel M, Aeschbach L, Houacine J, Fraering PC.

PLoS One. 2012;7(4):e35133. doi: 10.1371/journal.pone.0035133. Epub 2012 Apr 18.

14.

Identification of gamma-secretase inhibitor potency determinants on presenilin.

Zhao B, Yu M, Neitzel M, Marugg J, Jagodzinski J, Lee M, Hu K, Schenk D, Yednock T, Basi G.

J Biol Chem. 2008 Feb 1;283(5):2927-38. Epub 2007 Nov 21.

15.

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.

16.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

17.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6. Epub 2006 Oct 27.

PMID:
17071095
18.

Molecular neuropathology of Alzheimer dementia and therapeutic approaches.

Robakis NK.

Adv Exp Med Biol. 2015;822:1. doi: 10.1007/978-3-319-08927-0_1. No abstract available.

PMID:
25416969
19.

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

Futai E, Yagishita S, Ishiura S.

J Biol Chem. 2009 May 8;284(19):13013-22. doi: 10.1074/jbc.M807653200. Epub 2009 Mar 2.

20.

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.

Nature. 1999 Apr 8;398(6727):513-7.

PMID:
10206644

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