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Acidic stress promotes a glioma stem cell phenotype.

Hjelmeland AB, Wu Q, Heddleston JM, Choudhary GS, MacSwords J, Lathia JD, McLendon R, Lindner D, Sloan A, Rich JN.

Cell Death Differ. 2011 May;18(5):829-40. doi: 10.1038/cdd.2010.150. Epub 2010 Dec 3.


The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.

Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN.

Cell Cycle. 2009 Oct 15;8(20):3274-84. Epub 2009 Oct 3.


Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.

Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, Hjelmeland AB, Rich JN.

Cancer Cell. 2009 Jun 2;15(6):501-13. doi: 10.1016/j.ccr.2009.03.018.


Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.

Heddleston JM, Wu Q, Rivera M, Minhas S, Lathia JD, Sloan AE, Iliopoulos O, Hjelmeland AB, Rich JN.

Cell Death Differ. 2012 Mar;19(3):428-39. doi: 10.1038/cdd.2011.109. Epub 2011 Aug 12.


Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance.

Yang W, Wei J, Guo T, Shen Y, Liu F.

Exp Cell Res. 2014 Aug 1;326(1):22-35. doi: 10.1016/j.yexcr.2014.05.022. Epub 2014 Jun 12.


Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.

Soeda A, Park M, Lee D, Mintz A, Androutsellis-Theotokis A, McKay RD, Engh J, Iwama T, Kunisada T, Kassam AB, Pollack IF, Park DM.

Oncogene. 2009 Nov 12;28(45):3949-59. doi: 10.1038/onc.2009.252. Epub 2009 Aug 31.


Glioma-associated stem cells: a novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas.

Bourkoula E, Mangoni D, Ius T, Pucer A, Isola M, Musiello D, Marzinotto S, Toffoletto B, Sorrentino M, Palma A, Caponnetto F, Gregoraci G, Vindigni M, Pizzolitto S, Falconieri G, De Maglio G, Pecile V, Ruaro ME, Gri G, Parisse P, Casalis L, Scoles G, Skrap M, Beltrami CA, Beltrami AP, Cesselli D.

Stem Cells. 2014 May;32(5):1239-53. doi: 10.1002/stem.1605.


Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma.

Filatova A, Seidel S, Böğürcü N, Gräf S, Garvalov BK, Acker T.

Cancer Res. 2016 Oct 1;76(19):5845-5856. Epub 2016 Aug 3.


Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model.

Lee G, Auffinger B, Guo D, Hasan T, Deheeger M, Tobias AL, Kim JY, Atashi F, Zhang L, Lesniak MS, James CD, Ahmed AU.

Mol Cancer Ther. 2016 Dec;15(12):3064-3076. Epub 2016 Oct 7. Erratum in: Mol Cancer Ther. 2017 Jun;16(6):1199.


MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.

Bier A, Giladi N, Kronfeld N, Lee HK, Cazacu S, Finniss S, Xiang C, Poisson L, deCarvalho AC, Slavin S, Jacoby E, Yalon M, Toren A, Mikkelsen T, Brodie C.

Oncotarget. 2013 May;4(5):665-76.


Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors.

Mao XG, Yan M, Xue XY, Zhang X, Ren HG, Guo G, Wang P, Zhang W, Huo JL.

Lab Invest. 2011 Jul;91(7):1068-78. doi: 10.1038/labinvest.2011.56. Epub 2011 Apr 11.


Tumor vasculature and glioma stem cells: Contributions to glioma progression.

Jhaveri N, Chen TC, Hofman FM.

Cancer Lett. 2016 Oct 1;380(2):545-51. doi: 10.1016/j.canlet.2014.12.028. Epub 2014 Dec 16. Review.


The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment.

Filatova A, Acker T, Garvalov BK.

Biochim Biophys Acta. 2013 Feb;1830(2):2496-508. doi: 10.1016/j.bbagen.2012.10.008. Epub 2012 Oct 16.


Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro.

Huang Q, Zhang QB, Dong J, Wu YY, Shen YT, Zhao YD, Zhu YD, Diao Y, Wang AD, Lan Q.

BMC Cancer. 2008 Oct 22;8:304. doi: 10.1186/1471-2407-8-304.


An inhibitor of arachidonate 5-lipoxygenase, Nordy, induces differentiation and inhibits self-renewal of glioma stem-like cells.

Wang B, Yu SC, Jiang JY, Porter GW, Zhao LT, Wang Z, Tan H, Cui YH, Qian C, Ping YF, Bian XW.

Stem Cell Rev. 2011 Jun;7(2):458-70. doi: 10.1007/s12015-010-9175-9.


Expression of NANOG in human gliomas and its relationship with undifferentiated glioma cells.

Niu CS, Li DX, Liu YH, Fu XM, Tang SF, Li J.

Oncol Rep. 2011 Sep;26(3):593-601. doi: 10.3892/or.2011.1308. Epub 2011 May 13.


The PGI-KLF4 pathway regulates self-renewal of glioma stem cells residing in the mesenchymal niches in human gliomas.

Zhu XY, Wang L, Luan SH, Zhang HS, Huang WT, Wang NH.

Neoplasma. 2014;61(4):401-10. doi: 10.4149/neo_2014_049.


LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells.

Mao XG, Song SJ, Xue XY, Yan M, Wang L, Lin W, Guo G, Zhang X.

Cell Mol Neurobiol. 2013 Aug;33(6):851-65. doi: 10.1007/s10571-013-9951-6. Epub 2013 Jun 21.


Glioma stem cell maintenance: the role of the microenvironment.

Heddleston JM, Hitomi M, Venere M, Flavahan WA, Yang K, Kim Y, Minhas S, Rich JN, Hjelmeland AB.

Curr Pharm Des. 2011;17(23):2386-401. Review.

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