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LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL.

J Clin Invest. 2011 Jan;121(1):431-41. doi: 10.1172/JCI41681. Epub 2010 Dec 1.


Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice.

Warrier M, Hinds TD Jr, Ledford KJ, Cash HA, Patel PR, Bowman TA, Stechschulte LA, Yong W, Shou W, Najjar SM, Sanchez ER.

Endocrinology. 2010 Jul;151(7):3225-36. doi: 10.1210/en.2009-1158. Epub 2010 Apr 28.


Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.

Nader N, Ng SS, Wang Y, Abel BS, Chrousos GP, Kino T.

PLoS One. 2012;7(3):e26751. doi: 10.1371/journal.pone.0026751. Epub 2012 Mar 22.


Glucocorticoid response and promoter occupancy of the mouse LXRalpha gene.

Steffensen KR, Holter E, Alikhani N, Eskild W, Gustafsson JA.

Biochem Biophys Res Commun. 2003 Dec 19;312(3):716-24.


Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice.

Friedman JE, Sun Y, Ishizuka T, Farrell CJ, McCormack SE, Herron LM, Hakimi P, Lechner P, Yun JS.

J Biol Chem. 1997 Dec 12;272(50):31475-81.


Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.

Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC.

J Biol Chem. 2009 Sep 18;284(38):25593-601. doi: 10.1074/jbc.M109.025452. Epub 2009 Jul 23. Erratum in: J Biol Chem. 2012 Feb 3;287(6):4394.


Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice.

Korach-André M, Parini P, Larsson L, Arner A, Steffensen KR, Gustafsson JA.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E167-78. doi: 10.1152/ajpendo.00184.2009. Epub 2009 Aug 18.


Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis.

Winkler R, Benz V, Clemenz M, Bloch M, Foryst-Ludwig A, Wardat S, Witte N, Trappiel M, Namsolleck P, Mai K, Spranger J, Matthias G, Roloff T, Truee O, Kappert K, Schupp M, Matthias P, Kintscher U.

Diabetes. 2012 Feb;61(2):513-23. doi: 10.2337/db11-0313. Epub 2011 Dec 30.


Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRα-SREBP1c-dependent mechanism.

Zhang X, Liu J, Su W, Wu J, Wang C, Kong X, Gustafsson JÅ, Ding J, Ma X, Guan Y.

J Diabetes. 2014 May;6(3):212-20. doi: 10.1111/1753-0407.12081. Epub 2013 Sep 30.


Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC.

Endocrinology. 2006 Nov;147(11):5061-8. Epub 2006 Jul 27.


LXRalpha regulates human CETP expression in vitro and in transgenic mice.

Honzumi S, Shima A, Hiroshima A, Koieyama T, Ubukata N, Terasaka N.

Atherosclerosis. 2010 Sep;212(1):139-45. doi: 10.1016/j.atherosclerosis.2010.04.025. Epub 2010 Apr 29.


Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9. Epub 2006 Jul 6.


Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice.

Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC.

J Mol Endocrinol. 2008 Aug;41(2):53-64. doi: 10.1677/JME-08-0004. Epub 2008 Jun 4.


Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.

Watts LM, Manchem VP, Leedom TA, Rivard AL, McKay RA, Bao D, Neroladakis T, Monia BP, Bodenmiller DM, Cao JX, Zhang HY, Cox AL, Jacobs SJ, Michael MD, Sloop KW, Bhanot S.

Diabetes. 2005 Jun;54(6):1846-53.


Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

Kay HY, Kim WD, Hwang SJ, Choi HS, Gilroy RK, Wan YJ, Kim SG.

Antioxid Redox Signal. 2011 Oct 15;15(8):2135-46. doi: 10.1089/ars.2010.3834. Epub 2011 Jun 13.


Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBP-mediated activation.

Olswang Y, Blum B, Cassuto H, Cohen H, Biberman Y, Hanson RW, Reshef L.

J Biol Chem. 2003 Apr 11;278(15):12929-36. Epub 2003 Jan 30.


Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1.

Wong S, Tan K, Carey KT, Fukushima A, Tiganis T, Cole TJ.

Endocrinology. 2010 Jan;151(1):185-94. doi: 10.1210/en.2009-0590. Epub 2009 Dec 4.


Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.

O'Brien RM, Noisin EL, Suwanichkul A, Yamasaki T, Lucas PC, Wang JC, Powell DR, Granner DK.

Mol Cell Biol. 1995 Mar;15(3):1747-58.


Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

Lamia KA, Papp SJ, Yu RT, Barish GD, Uhlenhaut NH, Jonker JW, Downes M, Evans RM.

Nature. 2011 Dec 14;480(7378):552-6. doi: 10.1038/nature10700.

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