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Items: 1 to 20 of 121

1.

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.

Fei F, Kweon SM, Haataja L, De Sepulveda P, Groffen J, Heisterkamp N.

BMC Biochem. 2010 Dec 1;11:48. doi: 10.1186/1471-2091-11-48.

2.

Negative charges in the flexible N-terminal domain of Rho GDP-dissociation inhibitors (RhoGDIs) regulate the targeting of the RhoGDI-Rac1 complex to membranes.

Ueyama T, Son J, Kobayashi T, Hamada T, Nakamura T, Sakaguchi H, Shirafuji T, Saito N.

J Immunol. 2013 Sep 1;191(5):2560-9. doi: 10.4049/jimmunol.1300209. Epub 2013 Aug 5.

3.

Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.

Ugolev Y, Berdichevsky Y, Weinbaum C, Pick E.

J Biol Chem. 2008 Aug 8;283(32):22257-71. doi: 10.1074/jbc.M800734200. Epub 2008 May 27.

4.

Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.

DerMardirossian C, Schnelzer A, Bokoch GM.

Mol Cell. 2004 Jul 2;15(1):117-27.

5.

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor.

Kweon SM, Cho YJ, Minoo P, Groffen J, Heisterkamp N.

J Biol Chem. 2008 Feb 8;283(6):3023-30. Epub 2007 Dec 10.

6.

Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion.

Dovas A, Choi Y, Yoneda A, Multhaupt HA, Kwon SH, Kang D, Oh ES, Couchman JR.

J Biol Chem. 2010 Jul 23;285(30):23296-308. doi: 10.1074/jbc.M109.098129. Epub 2010 May 15.

7.

Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy.

Custodis F, Eberl M, Kilter H, Böhm M, Laufs U.

Cardiovasc Res. 2006 Jul 15;71(2):342-51. Epub 2006 Apr 19.

PMID:
16698001
8.

Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI.

Chianale F, Rainero E, Cianflone C, Bettio V, Pighini A, Porporato PE, Filigheddu N, Serini G, Sinigaglia F, Baldanzi G, Graziani A.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4182-7. doi: 10.1073/pnas.0908326107. Epub 2010 Feb 16.

9.

Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors.

Turner SJ, Zhuang S, Zhang T, Boss GR, Pilz RB.

Biochem Pharmacol. 2008 Jan 15;75(2):405-13. Epub 2007 Sep 1.

10.
11.

Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.

Lian LY, Barsukov I, Golovanov AP, Hawkins DI, Badii R, Sze KH, Keep NH, Bokoch GM, Roberts GC.

Structure. 2000 Jan 15;8(1):47-55.

12.

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

Scheffzek K, Stephan I, Jensen ON, Illenberger D, Gierschik P.

Nat Struct Biol. 2000 Feb;7(2):122-6.

PMID:
10655614
13.

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.

Castro-Castro A, Ojeda V, Barreira M, Sauzeau V, Navarro-Lérida I, Muriel O, Couceiro JR, Pimentel-Muíños FX, Del Pozo MA, Bustelo XR.

EMBO J. 2011 Aug 26;30(19):3913-27. doi: 10.1038/emboj.2011.310.

14.

Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.

Abramovici H, Mojtabaie P, Parks RJ, Zhong XP, Koretzky GA, Topham MK, Gee SH.

Mol Biol Cell. 2009 Apr;20(7):2049-59. doi: 10.1091/mbc.E07-12-1248. Epub 2009 Feb 11.

15.

An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells.

Gandhi PN, Gibson RM, Tong X, Miyoshi J, Takai Y, Konieczkowski M, Sedor JR, Wilson-Delfosse AL.

Biochem J. 2004 Mar 1;378(Pt 2):409-19.

16.

Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIα.

Oishi A, Makita N, Sato J, Iiri T.

J Biol Chem. 2012 Nov 9;287(46):38705-15. doi: 10.1074/jbc.M112.401547. Epub 2012 Sep 25.

17.

Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.

DerMardirossian C, Rocklin G, Seo JY, Bokoch GM.

Mol Biol Cell. 2006 Nov;17(11):4760-8. Epub 2006 Aug 30.

18.

FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling.

Pu J, Mao Y, Lei X, Yan Y, Lu X, Tian J, Yin X, Zhao G, Zhang B.

PLoS One. 2013 Aug 13;8(8):e73108. doi: 10.1371/journal.pone.0073108. eCollection 2013.

19.

In vivo dynamics of Rac-membrane interactions.

Moissoglu K, Slepchenko BM, Meller N, Horwitz AF, Schwartz MA.

Mol Biol Cell. 2006 Jun;17(6):2770-9. Epub 2006 Apr 5.

20.

Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.

Wang Z, Thurmond DC.

J Biol Chem. 2010 Feb 26;285(9):6186-97. doi: 10.1074/jbc.M109.072421. Epub 2009 Dec 22.

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