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Cytoplasmic deadenylation: regulation of mRNA fate.

Wiederhold K, Passmore LA.

Biochem Soc Trans. 2010 Dec;38(6):1531-6. doi: 10.1042/BST0381531. Review.


Deadenylation is a widespread effect of miRNA regulation.

Eulalio A, Huntzinger E, Nishihara T, Rehwinkel J, Fauser M, Izaurralde E.

RNA. 2009 Jan;15(1):21-32. doi: 10.1261/rna.1399509. Epub 2008 Nov 24.


Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases.

Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S.

Genes Dev. 2007 Dec 1;21(23):3135-48.


Deadenylation and P-bodies.

Chen CY, Shyu AB.

Adv Exp Med Biol. 2013;768:183-95. doi: 10.1007/978-1-4614-5107-5_11. Review.


CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.

Piao X, Zhang X, Wu L, Belasco JG.

Mol Cell Biol. 2010 Mar;30(6):1486-94. doi: 10.1128/MCB.01481-09. Epub 2010 Jan 11.


Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast.

Makino S, Mishima Y, Inoue K, Inada T.

J Biol Chem. 2015 Mar 27;290(13):8331-47. doi: 10.1074/jbc.M114.615088. Epub 2015 Feb 5.


Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae.

Tucker M, Staples RR, Valencia-Sanchez MA, Muhlrad D, Parker R.

EMBO J. 2002 Mar 15;21(6):1427-36.


CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4.

Ohn T, Chiang YC, Lee DJ, Yao G, Zhang C, Denis CL.

Nucleic Acids Res. 2007;35(9):3002-15. Epub 2007 Apr 16.


The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans.

Nousch M, Techritz N, Hampel D, Millonigg S, Eckmann CR.

J Cell Sci. 2013 Sep 15;126(Pt 18):4274-85. doi: 10.1242/jcs.132936. Epub 2013 Jul 10.


Cytoplasmic deadenylase Ccr4 is required for translational repression of LRG1 mRNA in the stationary phase.

Duy DL, Suda Y, Irie K.

PLoS One. 2017 Feb 23;12(2):e0172476. doi: 10.1371/journal.pone.0172476. eCollection 2017.


S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complex.

Rendl LM, Bieman MA, Smibert CA.

RNA. 2008 Jul;14(7):1328-36. doi: 10.1261/rna.955508. Epub 2008 May 9.


A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila.

Temme C, Zaessinger S, Meyer S, Simonelig M, Wahle E.

EMBO J. 2004 Jul 21;23(14):2862-71. Epub 2004 Jun 24.


Mechanisms of deadenylation-dependent decay.

Chen CY, Shyu AB.

Wiley Interdiscip Rev RNA. 2011 Mar-Apr;2(2):167-83. doi: 10.1002/wrna.40. Epub 2010 Sep 15. Review.


A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay.

Simón E, Séraphin B.

Nucleic Acids Res. 2007;35(18):6017-28. Epub 2007 Aug 30.


PUF3 acceleration of deadenylation in vivo can operate independently of CCR4 activity, possibly involving effects on the PAB1-mRNP structure.

Lee D, Ohn T, Chiang YC, Quigley G, Yao G, Liu Y, Denis CL.

J Mol Biol. 2010 Jun 18;399(4):562-75. doi: 10.1016/j.jmb.2010.04.034. Epub 2010 May 8.


Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae.

Hilgers V, Teixeira D, Parker R.

RNA. 2006 Oct;12(10):1835-45. Epub 2006 Aug 29.


Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.

Rouget C, Papin C, Boureux A, Meunier AC, Franco B, Robine N, Lai EC, Pelisson A, Simonelig M.

Nature. 2010 Oct 28;467(7319):1128-32. doi: 10.1038/nature09465. Epub 2010 Oct 17.


PAB1 self-association precludes its binding to poly(A), thereby accelerating CCR4 deadenylation in vivo.

Yao G, Chiang YC, Zhang C, Lee DJ, Laue TM, Denis CL.

Mol Cell Biol. 2007 Sep;27(17):6243-53. Epub 2007 Jul 9.


Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.

Van Etten J, Schagat TL, Hrit J, Weidmann CA, Brumbaugh J, Coon JJ, Goldstrohm AC.

J Biol Chem. 2012 Oct 19;287(43):36370-83. doi: 10.1074/jbc.M112.373522. Epub 2012 Sep 6.


PUF proteins bind Pop2p to regulate messenger RNAs.

Goldstrohm AC, Hook BA, Seay DJ, Wickens M.

Nat Struct Mol Biol. 2006 Jun;13(6):533-9. Epub 2006 May 21.


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