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Items: 1 to 20 of 96

1.

A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice.

Higashi K, Tomigahara Y, Shiraki H, Miyata K, Mikami T, Kimura T, Moro T, Inagaki Y, Kaneko H.

J Biol Chem. 2011 Feb 11;286(6):4485-92. doi: 10.1074/jbc.M110.151936.

2.

Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.

Higashi K, Inagaki Y, Fujimori K, Nakao A, Kaneko H, Nakatsuka I.

J Biol Chem. 2003 Oct 31;278(44):43470-9.

3.

A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.

Hasegawa M, Matsushita Y, Horikawa M, Higashi K, Tomigahara Y, Kaneko H, Shirasaki F, Fujimoto M, Takehara K, Sato S.

Arthritis Rheum. 2009 Nov;60(11):3465-75. doi: 10.1002/art.24934.

4.

Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, Kawada N, Namikawa K, Kiyama H, Bou-Gharios G, Watanabe T, Okazaki I, Ikeda K.

Gastroenterology. 2005 Jul;129(1):259-68.

PMID:
16012952
5.

Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.

Inagaki Y, Higashi K, Kushida M, Hong YY, Nakao S, Higashiyama R, Moro T, Itoh J, Mikami T, Kimura T, Shiota G, Kuwabara I, Okazaki I.

Gastroenterology. 2008 Apr;134(4):1180-90. doi: 10.1053/j.gastro.2008.01.014.

PMID:
18395096
6.

A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice.

Yamaoka H, Sumiyoshi H, Higashi K, Nakao S, Minakawa K, Sumida K, Saito K, Ikoma N, Mabuchi T, Ozawa A, Inagaki Y.

J Dermatol Sci. 2014 Jun;74(3):204-13. doi: 10.1016/j.jdermsci.2014.03.002.

PMID:
24702853
7.

A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene.

Sun W, Hou F, Panchenko MP, Smith BD.

Matrix Biol. 2001 Dec;20(8):527-41.

PMID:
11731270
8.

Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells.

Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, Ten Dijke P, Nakao A.

J Cell Physiol. 2001 Apr;187(1):117-23.

PMID:
11241356
9.

The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development.

Zhang Z, Zha Y, Hu W, Huang Z, Gao Z, Zang Y, Chen J, Dong L, Zhang J.

J Biol Chem. 2013 Dec 27;288(52):37082-93. doi: 10.1074/jbc.M113.517953.

10.

Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell.

Huang D, Wang Y, Wang L, Zhang F, Deng S, Wang R, Zhang Y, Huang K.

PLoS One. 2011;6(10):e27123. doi: 10.1371/journal.pone.0027123.

11.

Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.

Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T.

Biochem Biophys Res Commun. 2015 Dec 25;468(4):554-60. doi: 10.1016/j.bbrc.2015.10.123.

PMID:
26603932
12.

Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.

Moro T, Shimoyama Y, Kushida M, Hong YY, Nakao S, Higashiyama R, Sugioka Y, Inoue H, Okazaki I, Inagaki Y.

Life Sci. 2008 Oct 10;83(15-16):531-9. doi: 10.1016/j.lfs.2008.07.023.

PMID:
18771671
13.
14.

Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects.

Dooley S, Said HM, Gressner AM, Floege J, En-Nia A, Mertens PR.

J Biol Chem. 2006 Jan 20;281(3):1784-95.

15.

All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production.

Hisamori S, Tabata C, Kadokawa Y, Okoshi K, Tabata R, Mori A, Nagayama S, Watanabe G, Kubo H, Sakai Y.

Liver Int. 2008 Nov;28(9):1217-25. doi: 10.1111/j.1478-3231.2008.01745.x.

PMID:
18397230
16.

New role and molecular mechanism of Gadd45a in hepatic fibrosis.

Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG.

World J Gastroenterol. 2016 Mar 7;22(9):2779-88. doi: 10.3748/wjg.v22.i9.2779.

17.
18.

Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.

Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, de Crombrugghe B, Watanabe T, Okazaki I.

Hepatology. 2003 Oct;38(4):890-9.

PMID:
14512876
19.
20.

Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells.

Poncelet AC, Schnaper HW.

J Biol Chem. 2001 Mar 9;276(10):6983-92. Erratum in: J Biol Chem 2001 Dec 14;276(50):47746.

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