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21111054,22809809,18989830,20361990,19202563,19034627,20583967,21487929,17344806,12695351,29357810,12571232,19158313,16513849,17392393,23733841,22679214,17093007,14977870,12815172,18096673,21913896,15548381,23850985,11560876,17591676,21939362,20642445,29157826,18037906,33087449,12065440,17041008,18052847,25600204,15104253,23153057,21315811,17936931,11093784,21227907,28571685,20829393,12642468,20381613,32350061,12573484,20966044,26366873,20080160,32320483,21834667,15037195,18584988,15123723,11502872,29189189,12739762,12065438,25336106,20861742,10748001,34035124,23770461,17825266,11114890,23845848,14709622,16472102,12814963,12642470,19833845,28685622,25183402,19797611,33336382,27550199,19497360,12869653,20624854,22122233,20551241,33896369,25069801,16109480,10875679,12485946,28062541,14604466,20832446,29440451,24460184,22484313,10873607,11991950,27414036,12695359,20566695,21787672,15572372,22269145,25824487,27197997,14709618,23245243,10752642,17108058,19135037,14683479,22310298,19854261,19356095,16324277,23274663,21555507,14613717,17576808,14722322,11336976,21198441,28110334,16919048,19702527,15175893,15855724,12433810,14636322,12870655,20622021,24752503,30071242,19307295,22159698,18570159,12623754,17379461,19378387,15496645,23896737,19451401,27208383,29184146,12514743,18468591,19608694,18096694,24832206,20818746,24180433,22284482,16815319,15826607,18332045,19196842,32557519,11737189,16146350,11602520,12167562,15742976,23160467,29105855,29721716,14709631,15761118,12235278,17214607,25725071,15735612,36460477,18839173,11561777,20610882,16623664,20504912,17827783,23220176,14599235,19326768,25326287,10923861,20645063,23891548,30747554,35659627,23926955,26397835,19168709,9413920,12718301,30414935,11950795,22466549,27917125,16763015,25712654,26341324,17827782,22498647,9454825,20580705,23732298,25689036,16580901,10418969,18206661,18647599,19881256,22171088,23570537,30347615,24218150,29527807,19326769,21871880,31455676,25808545,35293300,16611858,30730576,25141173,20201776,33139460,20709133,20942813,19066872,16214878,19251823,23274770,17603218,23688499,15466162,31924695,21146967,11502735,18781911,35184385,24802986,25228302,18427905,23702042,22761658,19520773,12601364,17978482,10598750,20218903,28916285,12920173,18094037,9536002,12431788,21947724,29802934,12487729,23707768,12970884,19356119,11201056,11278292,31436536,12354121,18929567,24910238,27449409,35417848,19928584,15771232,32888176,11095572,30520061,22076448,12504080,12893520,31159144,23539296,15801540,33396476,25989892,22896671,34857529,18768384,17484516,32027962,15563456,31118196,12467917,21376070,31339646,32303457,30308189,32941854,34011532,11983567,33395575,30529742,27709010,27110874,20599501,28496040,33674270,21259441,32569997,15578943,11679585,15833926,25073399,22719896,32234672,31032736,18347083,17971810,14515060,24389476,23674377,20955791,29796228,23229390,20959500,14970873,24362577,17620218,20876786,15120618,19480557,22498895,30146095,35246464,12130690,8571393,20538049,31111189,30448524,36113565,22398970,34689256,19154420,11958559,11589781,22447117,19435144,31270214,12040753,15466163,19249324,26467767,23090669,33551819,10037683,33355212,23886699,24722393,18285471,18347084,12844133,26648056,10772626,22685215,17028159,12695340,24924386,23876819,33890704,23179081,27536444,18473749,15554232,19562679,31472121,21996064,16819505,12417264,36223846,29403890,9770465,11162490,16724927,20408500,29569723,24252946,18971317,31158489,24681287,28546420,18304819,17220562,9592188,32464781,20167002,14551287,24088256,24889062,17207564,7557864,24235770,11455014,22673034,31857909,11976065,22936314,21628639,23843424,25157098,25721668,32050158,15681899,29923436,11744616,32482757,24157406,24859622,14599457,21862689,12206849,16470914,12523495,11876499,26336590,12642465,20151218,15237857,32235864,18669588,10901135,23550066,28411281,30234976,32187570,21441468,31432507,9708908,23665929,31868891,18447001,30573465,31057647,18350255,29721322,32503882,21620874,31465819,16470567,12815159,28963035,11408150,24910237,17017527,34915831,33150952,20147837,16308281,33863817,31689116,23770199,19056338,14512885,35934190,28821485,24172718,25366484,23834474,31902468,25472767,12130704,32931777,32955797,11192002,12045201,28089783,17193320,19230594,16169652,30919109,35872289,9741959,25834921,33647240,35562325,10381914,37060457,10903421,32839278,21930824,28345929,22577882,24764148,16473453,17107849,31096615,10643869,35953158,31564409,14977871,22447115,18729327,26798158,18274954,18220847,36906857,15379787,16724929,21436605,19467232,7507267,36775544,19464434,24191259,28254951,10461547,26377104,26838175,21422673,32583524,24941853,11033069,23167901,35748891,10069527,16753005,29569712,27713827,22292071,30087611,34087279,34359083,21998292,29420809,30823561,27311637,20642555,30004443,32106230,22008537,35889510,22512564,19211671,21208171,29870591,15627040,19282397,23840296,32874920,19144770,32270716,36110298,24671884,17936932,35599347,30340248,24695277,32989483,36473234,14581727,12504802,34241998,18261364,332603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Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.

Rhodes SP, Otten JN, Hingorani GP, Hartley DP, Franklin RB. Rhodes SP, et al. J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):223-6. doi: 10.1016/j.vascn.2010.11.002. Epub 2010 Nov 24. J Pharmacol Toxicol Methods. 2011. PMID: 21111054

An 'all-inclusive' 96-well cytochrome P450 induction method: measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes.

Halladay JS, Wong S, Khojasteh SC, Grepper S. Halladay JS, et al. J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):270-5. doi: 10.1016/j.vascn.2012.07.004. Epub 2012 Jul 15. J Pharmacol Toxicol Methods. 2012. PMID: 22809809

Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.

Kenny JR, Chen L, McGinnity DF, Grime K, Shakesheff KM, Thomson B, Riley R. Kenny JR, et al. Xenobiotica. 2008 Dec;38(12):1500-17. doi: 10.1080/00498250802495846. Xenobiotica. 2008. PMID: 18989830

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.

Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD. Casabar RC, et al. Toxicol Appl Pharmacol. 2010 Jun 15;245(3):335-43. doi: 10.1016/j.taap.2010.03.017. Epub 2010 Mar 31. Toxicol Appl Pharmacol. 2010. PMID: 20361990

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.

Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL. Sahi J, et al. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58. doi: 10.1002/jbt.20264. J Biochem Mol Toxicol. 2009. PMID: 19202563

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.

Li L, Stanton JD, Tolson AH, Luo Y, Wang H. Li L, et al. Pharm Res. 2009 Apr;26(4):872-82. doi: 10.1007/s11095-008-9788-8. Epub 2008 Nov 26. Pharm Res. 2009. PMID: 19034627 Free PMC article.

A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin.

Zhang JG, Ho T, Callendrello AL, Crespi CL, Stresser DM. Zhang JG, et al. Drug Metab Lett. 2010 Dec;4(4):185-94. doi: 10.2174/187231210792928224. Drug Metab Lett. 2010. PMID: 20583967

The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.

Wang D, Li L, Fuhrman J, Ferguson S, Wang H. Wang D, et al. Pharm Res. 2011 Aug;28(8):2034-44. doi: 10.1007/s11095-011-0429-2. Epub 2011 Apr 13. Pharm Res. 2011. PMID: 21487929 Free PMC article.

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole.

Saussele T, Burk O, Blievernicht JK, Klein K, Nussler A, Nussler N, Hengstler JG, Eichelbaum M, Schwab M, Zanger UM. Saussele T, et al. Clin Pharmacol Ther. 2007 Sep;82(3):265-74. doi: 10.1038/sj.clpt.6100138. Epub 2007 Mar 7. Clin Pharmacol Ther. 2007. PMID: 17344806

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.

Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL. Wang H, et al. Drug Metab Dispos. 2003 May;31(5):620-30. doi: 10.1124/dmd.31.5.620. Drug Metab Dispos. 2003. PMID: 12695351

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