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Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV.

J Neurosci. 2010 Nov 17;30(46):15521-34. doi: 10.1523/JNEUROSCI.4437-10.2010.


Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.

Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV.

Mol Neurodegener. 2011 Feb 3;6:13. doi: 10.1186/1750-1326-6-13.


Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV.

Blood. 2010 Jun 10;115(23):4963-72. doi: 10.1182/blood-2010-01-262386. Epub 2010 Mar 26.


PI3K/Akt signaling pathway is required for neuroprotection of thalidomide on hypoxic-ischemic cortical neurons in vitro.

Zhang L, Qu Y, Tang J, Chen D, Fu X, Mao M, Mu D.

Brain Res. 2010 Oct 21;1357:157-65. doi: 10.1016/j.brainres.2010.08.007. Epub 2010 Aug 10.


The TLR9 ligand, CpG-ODN, induces protection against cerebral ischemia/reperfusion injury via activation of PI3K/Akt signaling.

Lu C, Ha T, Wang X, Liu L, Zhang X, Kimbrough EO, Sha Z, Guan M, Schweitzer J, Kalbfleisch J, Williams D, Li C.

J Am Heart Assoc. 2014 Apr 10;3(2):e000629. doi: 10.1161/JAHA.113.000629.


Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway.

Wang YB, Wang JJ, Wang SH, Liu SS, Cao JY, Li XM, Qiu S, Luo JH.

J Neurosci. 2012 Aug 29;32(35):11919-29. doi: 10.1523/JNEUROSCI.3852-11.2012.


The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells.

Park HJ, Baen JY, Lee YJ, Choi YH, Kang JL.

Mol Biol Cell. 2012 Aug;23(16):3254-65. doi: 10.1091/mbc.E12-01-0029. Epub 2012 Jun 27.


Neuregulin1beta1 antagonizes apoptosis via ErbB4-dependent activation of PI3-kinase/Akt in APP/PS1 transgenic mice.

Cui W, Tao J, Wang Z, Ren M, Zhang Y, Sun Y, Peng Y, Li R.

Neurochem Res. 2013 Nov;38(11):2237-46. doi: 10.1007/s11064-013-1131-z. Epub 2013 Aug 28.


Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

Brown JE, Krodel M, Pazos M, Lai C, Prieto AL.

PLoS One. 2012;7(5):e36800. doi: 10.1371/journal.pone.0036800. Epub 2012 May 14.


Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H₂O₂-induced neural progenitor cell injury.

Wu YM, Jin R, Yang L, Zhang J, Yang Q, Guo YY, Li XB, Liu SB, Luo XX, Zhao MG.

Neuroscience. 2013 Jun 14;240:54-62. doi: 10.1016/j.neuroscience.2013.02.037. Epub 2013 Feb 26.


Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.

Jantas D, Jaworska-Feil L, Lipkowski AW, Lason W.

Neuropeptides. 2009 Oct;43(5):371-85. doi: 10.1016/j.npep.2009.07.002. Epub 2009 Aug 8.


Activation of the histaminergic H3 receptor induces phosphorylation of the Akt/GSK-3 beta pathway in cultured cortical neurons and protects against neurotoxic insults.

Mariottini C, Scartabelli T, Bongers G, Arrigucci S, Nosi D, Leurs R, Chiarugi A, Blandina P, Pellegrini-Giampietro DE, Passani MB.

J Neurochem. 2009 Sep;110(5):1469-78. doi: 10.1111/j.1471-4159.2009.06249.x. Epub 2009 Jun 22.


Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G.

Elife. 2014 Sep 29;3. doi: 10.7554/eLife.03385.


Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice.

Pierce A, Xu M, Bliesner B, Liu Z, Richards J, Tobet S, Wierman ME.

Mol Cell Endocrinol. 2011 Jun 6;339(1-2):151-8. doi: 10.1016/j.mce.2011.04.007. Epub 2011 Apr 22.


Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons.

Prieto AL, O'Dell S, Varnum B, Lai C.

Neuroscience. 2007 Dec 5;150(2):319-34. Epub 2007 Sep 26.


Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway.

Zhang H, Xiong X, Liu J, Gu L, Li F, Wan Y, Xu S.

Anesth Analg. 2016 May;122(5):1377-84. doi: 10.1213/ANE.0000000000001172.


Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons.

Leinninger GM, Backus C, Uhler MD, Lentz SI, Feldman EL.

FASEB J. 2004 Oct;18(13):1544-6. Epub 2004 Aug 19.


Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.

Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, Calvo S, Soler RM, Galindo MF, Jordán J.

Neurobiol Dis. 2006 Nov;24(2):296-307. Epub 2006 Sep 15.


Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage.

Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J.

J Neurosci. 2002 May 15;22(10):3898-909.


P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.

Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, Ding Z.

J Thromb Haemost. 2013 Jan;11(1):149-60. doi: 10.1111/jth.12063.

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