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Items: 1 to 20 of 113

1.

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV.

J Neurosci. 2010 Nov 17;30(46):15521-34. doi: 10.1523/JNEUROSCI.4437-10.2010.

2.

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.

Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV.

Mol Neurodegener. 2011 Feb 3;6:13. doi: 10.1186/1750-1326-6-13.

3.

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV.

Blood. 2010 Jun 10;115(23):4963-72. doi: 10.1182/blood-2010-01-262386. Epub 2010 Mar 26.

4.

PI3K/Akt signaling pathway is required for neuroprotection of thalidomide on hypoxic-ischemic cortical neurons in vitro.

Zhang L, Qu Y, Tang J, Chen D, Fu X, Mao M, Mu D.

Brain Res. 2010 Oct 21;1357:157-65. doi: 10.1016/j.brainres.2010.08.007. Epub 2010 Aug 10.

PMID:
20705061
5.

The TLR9 ligand, CpG-ODN, induces protection against cerebral ischemia/reperfusion injury via activation of PI3K/Akt signaling.

Lu C, Ha T, Wang X, Liu L, Zhang X, Kimbrough EO, Sha Z, Guan M, Schweitzer J, Kalbfleisch J, Williams D, Li C.

J Am Heart Assoc. 2014 Apr 10;3(2):e000629. doi: 10.1161/JAHA.113.000629.

6.

Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway.

Wang YB, Wang JJ, Wang SH, Liu SS, Cao JY, Li XM, Qiu S, Luo JH.

J Neurosci. 2012 Aug 29;32(35):11919-29. doi: 10.1523/JNEUROSCI.3852-11.2012.

7.

The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells.

Park HJ, Baen JY, Lee YJ, Choi YH, Kang JL.

Mol Biol Cell. 2012 Aug;23(16):3254-65. doi: 10.1091/mbc.E12-01-0029. Epub 2012 Jun 27.

8.

Neuregulin1beta1 antagonizes apoptosis via ErbB4-dependent activation of PI3-kinase/Akt in APP/PS1 transgenic mice.

Cui W, Tao J, Wang Z, Ren M, Zhang Y, Sun Y, Peng Y, Li R.

Neurochem Res. 2013 Nov;38(11):2237-46. doi: 10.1007/s11064-013-1131-z. Epub 2013 Aug 28.

PMID:
23982319
9.

Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

Brown JE, Krodel M, Pazos M, Lai C, Prieto AL.

PLoS One. 2012;7(5):e36800. doi: 10.1371/journal.pone.0036800. Epub 2012 May 14.

10.

Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H₂O₂-induced neural progenitor cell injury.

Wu YM, Jin R, Yang L, Zhang J, Yang Q, Guo YY, Li XB, Liu SB, Luo XX, Zhao MG.

Neuroscience. 2013 Jun 14;240:54-62. doi: 10.1016/j.neuroscience.2013.02.037. Epub 2013 Feb 26.

PMID:
23485815
11.

Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.

Jantas D, Jaworska-Feil L, Lipkowski AW, Lason W.

Neuropeptides. 2009 Oct;43(5):371-85. doi: 10.1016/j.npep.2009.07.002. Epub 2009 Aug 8.

PMID:
19666192
12.

Activation of the histaminergic H3 receptor induces phosphorylation of the Akt/GSK-3 beta pathway in cultured cortical neurons and protects against neurotoxic insults.

Mariottini C, Scartabelli T, Bongers G, Arrigucci S, Nosi D, Leurs R, Chiarugi A, Blandina P, Pellegrini-Giampietro DE, Passani MB.

J Neurochem. 2009 Sep;110(5):1469-78. doi: 10.1111/j.1471-4159.2009.06249.x. Epub 2009 Jun 22.

13.

Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G.

Elife. 2014 Sep 29;3. doi: 10.7554/eLife.03385.

14.

Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice.

Pierce A, Xu M, Bliesner B, Liu Z, Richards J, Tobet S, Wierman ME.

Mol Cell Endocrinol. 2011 Jun 6;339(1-2):151-8. doi: 10.1016/j.mce.2011.04.007. Epub 2011 Apr 22.

15.

Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons.

Prieto AL, O'Dell S, Varnum B, Lai C.

Neuroscience. 2007 Dec 5;150(2):319-34. Epub 2007 Sep 26.

16.

Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway.

Zhang H, Xiong X, Liu J, Gu L, Li F, Wan Y, Xu S.

Anesth Analg. 2016 May;122(5):1377-84. doi: 10.1213/ANE.0000000000001172.

PMID:
26859875
17.

Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons.

Leinninger GM, Backus C, Uhler MD, Lentz SI, Feldman EL.

FASEB J. 2004 Oct;18(13):1544-6. Epub 2004 Aug 19.

PMID:
15319368
18.

Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.

Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, Calvo S, Soler RM, Galindo MF, Jordán J.

Neurobiol Dis. 2006 Nov;24(2):296-307. Epub 2006 Sep 15.

PMID:
16978869
19.

Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage.

Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J.

J Neurosci. 2002 May 15;22(10):3898-909.

20.

P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.

Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, Ding Z.

J Thromb Haemost. 2013 Jan;11(1):149-60. doi: 10.1111/jth.12063.

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