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Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.

Dorr CR, Yemets S, Kolomitsyna O, Krasutsky P, Mansky LM.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):542-5. doi: 10.1016/j.bmcl.2010.10.078.


Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

Dang Z, Lai W, Qian K, Ho P, Lee KH, Chen CH, Huang L.

J Med Chem. 2009 Dec 10;52(23):7887-91. doi: 10.1021/jm9004253.


Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

Qian K, Bori ID, Chen CH, Huang L, Lee KH.

J Med Chem. 2012 Sep 27;55(18):8128-36. Epub 2012 Sep 14.


Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Qian K, Kuo RY, Chen CH, Huang L, Morris-Natschke SL, Lee KH.

J Med Chem. 2010 Apr 22;53(8):3133-41. doi: 10.1021/jm901782m.


Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Huang L, Yuan X, Aiken C, Chen CH.

Antimicrob Agents Chemother. 2004 Feb;48(2):663-5.


Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives.

Kashiwada Y, Chiyo J, Ikeshiro Y, Nagao T, Okabe H, Cosentino LM, Fowke K, Morris-Natschke SL, Lee KH.

Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1387-90.


Synthesis of piscidinol A derivatives and their ability to inhibit HIV-1 protease.

Wei Y, Ma CM, Jiang TB, Du J, Zhou X, Liu GQ, Hattori M.

J Asian Nat Prod Res. 2015;17(11):1079-90. doi: 10.1080/10286020.2015.1084505. Epub 2015 Oct 11.


Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

Qian K, Nakagawa-Goto K, Yu D, Morris-Natschke SL, Nitz TJ, Kilgore N, Allaway GP, Lee KH.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6553-7.


Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors.

Urano E, Ablan SD, Mandt R, Pauly GT, Sigano DM, Schneider JP, Martin DE, Nitz TJ, Wild CT, Freed EO.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):190-7. doi: 10.1128/AAC.02121-15.


Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

Li J, Goto M, Yang X, Morris-Natschke SL, Huang L, Chen CH, Lee KH.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):68-71. doi: 10.1016/j.bmcl.2015.11.029. Epub 2015 Nov 11.


Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.

Huang L, Ho P, Lee KH, Chen CH.

Bioorg Med Chem. 2006 Apr 1;14(7):2279-89. Epub 2005 Nov 28.


C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

Liu Z, Swidorski JJ, Nowicka-Sans B, Terry B, Protack T, Lin Z, Samanta H, Zhang S, Li Z, Parker DD, Rahematpura S, Jenkins S, Beno BR, Krystal M, Meanwell NA, Dicker IB, Regueiro-Ren A.

Bioorg Med Chem. 2016 Apr 15;24(8):1757-70. doi: 10.1016/j.bmc.2016.03.001. Epub 2016 Mar 2.


Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.

Zhang P, Xu L, Qian K, Liu J, Zhang L, Lee KH, Sun H.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):338-41. doi: 10.1016/j.bmcl.2010.11.004. Epub 2010 Nov 5.


Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

Dang Z, Qian K, Ho P, Zhu L, Lee KH, Huang L, Chen CH.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5190-4. doi: 10.1016/j.bmcl.2012.06.080. Epub 2012 Jul 3.


Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.

Sun IC, Wang HK, Kashiwada Y, Shen JK, Cosentino LM, Chen CH, Yang LM, Lee KH.

J Med Chem. 1998 Nov 5;41(23):4648-57.


New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

Dang Z, Ho P, Zhu L, Qian K, Lee KH, Huang L, Chen CH.

J Med Chem. 2013 Mar 14;56(5):2029-37. doi: 10.1021/jm3016969. Epub 2013 Feb 20.


Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.

Sun IC, Shen JK, Wang HK, Cosentino LM, Lee KH.

Bioorg Med Chem Lett. 1998 May 19;8(10):1267-72.


Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.

Sun IC, Chen CH, Kashiwada Y, Wu JH, Wang HK, Lee KH.

J Med Chem. 2002 Sep 12;45(19):4271-5.


[Advances in the study of structural modifications and biological activities of betulinic acids].

Lan P, Zhang DM, Chen WM, Ye WC.

Yao Xue Xue Bao. 2010 Nov;45(11):1339-45. Review. Chinese.


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