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Items: 1 to 20 of 113

1.

Symmetrical choline-derived dications display strong anti-kinetoplastid activity.

Ibrahim HM, Al-Salabi MI, El Sabbagh N, Quashie NB, Alkhaldi AA, Escale R, Smith TK, Vial HJ, de Koning HP.

J Antimicrob Chemother. 2011 Jan;66(1):111-25. doi: 10.1093/jac/dkq401. Epub 2010 Nov 14.

2.

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei.

Alkhaldi AA, Martinek J, Panicucci B, Dardonville C, Zíková A, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2015 Dec 11;6(1):23-34. doi: 10.1016/j.ijpddr.2015.12.002. eCollection 2016 Apr.

3.

Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms.

Monzote L, García M, Pastor J, Gil L, Scull R, Maes L, Cos P, Gille L.

Exp Parasitol. 2014 Jan;136:20-6. doi: 10.1016/j.exppara.2013.10.007. Epub 2013 Oct 31.

PMID:
24184772
4.

Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.

Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi MI, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning HP, Augustyns K.

Antimicrob Agents Chemother. 2010 May;54(5):1900-8. doi: 10.1128/AAC.01787-09. Epub 2010 Mar 1.

5.

Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.

Ganfon H, Bero J, Tchinda AT, Gbaguidi F, Gbenou J, Moudachirou M, Frédérich M, Quetin-Leclercq J.

J Ethnopharmacol. 2012 May 7;141(1):411-7. doi: 10.1016/j.jep.2012.03.002. Epub 2012 Mar 13.

PMID:
22440261
6.

In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors.

Bangs JD, Ransom DA, Nimick M, Christie G, Hooper NM.

Mol Biochem Parasitol. 2001 Apr 25;114(1):111-7.

PMID:
11356520
7.

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.

Rodenko B, van der Burg AM, Wanner MJ, Kaiser M, Brun R, Gould M, de Koning HP, Koomen GJ.

Antimicrob Agents Chemother. 2007 Nov;51(11):3796-802. Epub 2007 Aug 13.

8.

Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei.

Worthen C, Jensen BC, Parsons M.

PLoS Negl Trop Dis. 2010 May 4;4(5):e678. doi: 10.1371/journal.pntd.0000678.

9.

Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds.

Khabnadideh S, Tan CL, Croft SL, Kendrick H, Yardley V, Gilbert IH.

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1237-9.

PMID:
10866389
10.

Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani.

Chibale K, Visser M, Yardley V, Croft SL, Fairlamb AH.

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1147-50.

PMID:
10866368
11.

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

Gómez-Pérez V, Manzano JI, García-Hernández R, Castanys S, Campos Rosa JM, Gamarro F.

Antimicrob Agents Chemother. 2014 Jul;58(7):4103-12. doi: 10.1128/AAC.02481-13. Epub 2014 May 5.

12.

Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro.

Chan-Bacab MJ, Hernández-Núñez E, Navarrete-Vázquez G.

J Antimicrob Chemother. 2009 Jun;63(6):1292-3. doi: 10.1093/jac/dkp117. Epub 2009 Apr 4. No abstract available.

PMID:
19346519
13.

Mitochondrial damage contribute to epigallocatechin-3-gallate induced death in Leishmania amazonensis.

Inacio JD, Canto-Cavalheiro MM, Menna-Barreto RF, Almeida-Amaral EE.

Exp Parasitol. 2012 Oct;132(2):151-5. doi: 10.1016/j.exppara.2012.06.008. Epub 2012 Jun 23.

14.

In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei brucei.

del Rayo Camacho M, Phillipson JD, Croft SL, Rock P, Marshall SJ, Schiff PL Jr.

Phytother Res. 2002 Aug;16(5):432-6. Erratum in: Phytother Res 2002 Sep;16(6):602.

PMID:
12203262
15.

Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles.

Cottrell DM, Capers J, Salem MM, DeLuca-Fradley K, Croft SL, Werbovetz KA.

Bioorg Med Chem. 2004 Jun 1;12(11):2815-24.

PMID:
15142541
16.

Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.

Lux H, Heise N, Klenner T, Hart D, Opperdoes FR.

Mol Biochem Parasitol. 2000 Nov;111(1):1-14.

PMID:
11087912
17.

Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.

Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C.

J Med Chem. 2012 Mar 22;55(6):2606-22. doi: 10.1021/jm2014259. Epub 2012 Mar 6.

PMID:
22390399
18.

Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives.

Audisio D, Messaoudi S, Cojean S, Peyrat JF, Brion JD, Bories C, Huteau F, Loiseau PM, Alami M.

Eur J Med Chem. 2012 Jun;52:44-50. doi: 10.1016/j.ejmech.2012.03.003. Epub 2012 Mar 16.

PMID:
22472166
19.

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

Martin MB, Grimley JS, Lewis JC, Heath HT 3rd, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E.

J Med Chem. 2001 Mar 15;44(6):909-16.

PMID:
11300872
20.

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

Smith VC, Cleghorn LA, Woodland A, Spinks D, Hallyburton I, Collie IT, Mok NY, Norval S, Brenk R, Fairlamb AH, Frearson JA, Read KD, Gilbert IH, Wyatt PG.

ChemMedChem. 2011 Oct 4;6(10):1832-40. doi: 10.1002/cmdc.201100278. Epub 2011 Aug 10.

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