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Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.

Parra A, Madrid R, Echevarria D, del Olmo S, Morenilla-Palao C, Acosta MC, Gallar J, Dhaka A, Viana F, Belmonte C.

Nat Med. 2010 Dec;16(12):1396-9. doi: 10.1038/nm.2264.


Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.

Mälkiä A, Madrid R, Meseguer V, de la Peña E, Valero M, Belmonte C, Viana F.

J Physiol. 2007 May 15;581(Pt 1):155-74.


Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease.

Kovács I, Luna C, Quirce S, Mizerska K, Callejo G, Riestra A, Fernández-Sánchez L, Meseguer VM, Cuenca N, Merayo-Lloves J, Acosta MC, Gasull X, Belmonte C, Gallar J.

Pain. 2016 Feb;157(2):399-417. doi: 10.1097/j.pain.0000000000000455.


Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.

Madrid R, Donovan-Rodríguez T, Meseguer V, Acosta MC, Belmonte C, Viana F.

J Neurosci. 2006 Nov 29;26(48):12512-25.


Amplified cold transduction in native nociceptors by M-channel inhibition.

Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Reeh PW, Zimmermann K.

J Neurosci. 2013 Oct 16;33(42):16627-41. doi: 10.1523/JNEUROSCI.1473-13.2013.


Tear fluid hyperosmolality increases nerve impulse activity of cold thermoreceptor endings of the cornea.

Parra A, Gonzalez-Gonzalez O, Gallar J, Belmonte C.

Pain. 2014 Aug;155(8):1481-91. doi: 10.1016/j.pain.2014.04.025.


Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells.

Kurose M, Meng ID.

J Neurophysiol. 2013 Jul;110(2):495-504. doi: 10.1152/jn.00222.2013.


Human lung epithelial cells express a functional cold-sensing TRPM8 variant.

Sabnis AS, Shadid M, Yost GS, Reilly CA.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):466-74. doi: 10.1165/rcmb.2007-0440OC.


Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents.

Robbins A, Kurose M, Winterson BJ, Meng ID.

Invest Ophthalmol Vis Sci. 2012 Oct 9;53(11):7034-42. doi: 10.1167/iovs.12-10025.


N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons.

Pertusa M, Madrid R, Morenilla-Palao C, Belmonte C, Viana F.

J Biol Chem. 2012 May 25;287(22):18218-29. doi: 10.1074/jbc.M111.312645.


Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels.

Madrid R, de la Peña E, Donovan-Rodriguez T, Belmonte C, Viana F.

J Neurosci. 2009 Mar 11;29(10):3120-31. doi: 10.1523/JNEUROSCI.4778-08.2009.


Regulation of TRPM8 channel activity.

Yudin Y, Rohacs T.

Mol Cell Endocrinol. 2012 Apr 28;353(1-2):68-74. doi: 10.1016/j.mce.2011.10.023. Review.


Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease.

Hirata H, Meng ID.

Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3969-76. doi: 10.1167/iovs.09-4744.


The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.

Gentry C, Stoakley N, Andersson DA, Bevan S.

Mol Pain. 2010 Jan 21;6:4. doi: 10.1186/1744-8069-6-4.


Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.

Morenilla-Palao C, Luis E, Fernández-Peña C, Quintero E, Weaver JL, Bayliss DA, Viana F.

Cell Rep. 2014 Sep 11;8(5):1571-82. doi: 10.1016/j.celrep.2014.08.003.


Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors.

Fernández JA, Skryma R, Bidaux G, Magleby KL, Scholfield CN, McGeown JG, Prevarskaya N, Zholos AV.

J Biol Chem. 2012 Jan 27;287(5):2963-70. doi: 10.1074/jbc.M111.272823.


Emergence of functional sensory subtypes as defined by transient receptor potential channel expression.

Hjerling-Leffler J, Alqatari M, Ernfors P, Koltzenburg M.

J Neurosci. 2007 Mar 7;27(10):2435-43.


Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis.

Acosta MC, Luna C, Quirce S, Belmonte C, Gallar J.

Pain. 2013 Nov;154(11):2353-62. doi: 10.1016/j.pain.2013.07.012.


Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

Malkia A, Pertusa M, Fernández-Ballester G, Ferrer-Montiel A, Viana F.

Mol Pain. 2009 Nov 3;5:62. doi: 10.1186/1744-8069-5-62.

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