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Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation.

Sliter DA, Aguiar M, Gygi SP, Wojcikiewicz RJ.

J Biol Chem. 2011 Jan 14;286(2):1074-82. doi: 10.1074/jbc.M110.188383. Epub 2010 Nov 11.


Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination.

Sliter DA, Kubota K, Kirkpatrick DS, Alzayady KJ, Gygi SP, Wojcikiewicz RJ.

J Biol Chem. 2008 Dec 19;283(51):35319-28. doi: 10.1074/jbc.M807288200. Epub 2008 Oct 27.


Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors.

Alzayady KJ, Panning MM, Kelley GG, Wojcikiewicz RJ.

J Biol Chem. 2005 Oct 14;280(41):34530-7. Epub 2005 Aug 15.


Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.

Wojcikiewicz RJ, Xu Q, Webster JM, Alzayady K, Gao C.

J Biol Chem. 2003 Jan 10;278(2):940-7. Epub 2002 Nov 5.


RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.

Lu JP, Wang Y, Sliter DA, Pearce MM, Wojcikiewicz RJ.

J Biol Chem. 2011 Jul 8;286(27):24426-33. doi: 10.1074/jbc.M111.251983. Epub 2011 May 24.


A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling.

Wright FA, Lu JP, Sliter DA, Dupré N, Rouleau GA, Wojcikiewicz RJ.

J Biol Chem. 2015 May 29;290(22):13948-57. doi: 10.1074/jbc.M115.655043. Epub 2015 Apr 16.


Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.

Zhao G, Neeb ZP, Leo MD, Pachuau J, Adebiyi A, Ouyang K, Chen J, Jaggar JH.

J Gen Physiol. 2010 Sep;136(3):283-91. doi: 10.1085/jgp.201010453. Epub 2010 Aug 16.


Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.

Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP.

Nat Cell Biol. 2006 Jul;8(7):700-10. Epub 2006 Jun 25. Erratum in: Nat Cell Biol. 2006 Aug;8(8):896.


Differential modulation of inositol 1,4,5-trisphosphate receptor type 1 and type 3 by ATP.

Maes K, Missiaen L, De Smet P, Vanlingen S, Callewaert G, Parys JB, De Smedt H.

Cell Calcium. 2000 May;27(5):257-67.


Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL.

J Biol Chem. 2007 Jun 15;282(24):17375-86. Epub 2007 Apr 10.


The role of Ca2+ in triggering inositol 1,4,5-trisphosphate receptor ubiquitination.

Alzayady KJ, Wojcikiewicz RJ.

Biochem J. 2005 Dec 15;392(Pt 3):601-6.


Chapter 4 - Inositol 1,4,5-Trisphosphate Receptor Ubiquitination.

Wright FA, Wojcikiewicz RJ.

Prog Mol Biol Transl Sci. 2016;141:141-59. doi: 10.1016/bs.pmbts.2016.02.004. Epub 2016 Mar 30. Review.


IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor.

Ando H, Mizutani A, Matsu-ura T, Mikoshiba K.

J Biol Chem. 2003 Mar 21;278(12):10602-12. Epub 2003 Jan 13.


Mechanism of proteasomal degradation of inositol trisphosphate receptors in CHO-K1 cells.

Bhanumathy CD, Nakao SK, Joseph SK.

J Biol Chem. 2006 Feb 10;281(6):3722-30. Epub 2005 Nov 29.


The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome.

Jacobson AD, Zhang NY, Xu P, Han KJ, Noone S, Peng J, Liu CW.

J Biol Chem. 2009 Dec 18;284(51):35485-94. doi: 10.1074/jbc.M109.052928.


The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.

Grice GL, Lobb IT, Weekes MP, Gygi SP, Antrobus R, Nathan JA.

Cell Rep. 2015 Jul 28;12(4):545-53. doi: 10.1016/j.celrep.2015.06.061. Epub 2015 Jul 16.


An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

Pearce MM, Wormer DB, Wilkens S, Wojcikiewicz RJ.

J Biol Chem. 2009 Apr 17;284(16):10433-45. doi: 10.1074/jbc.M809801200. Epub 2009 Feb 24.


IP(3) receptors: the search for structure.

Taylor CW, da Fonseca PC, Morris EP.

Trends Biochem Sci. 2004 Apr;29(4):210-9. Review.


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