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Items: 1 to 20 of 88

1.

Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro.

Aura AM, Mattila I, Hyötyläinen T, Gopalacharyulu P, Bounsaythip C, Orešič M, Oksman-Caldentey KM.

Mol Biosyst. 2011 Feb;7(2):437-46. doi: 10.1039/c0mb00023j. Epub 2010 Nov 8.

PMID:
21060933
2.

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s.

Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison BH, Vyas KP.

Drug Metab Dispos. 1997 Oct;25(10):1191-9.

3.

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization.

Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA.

Drug Metab Dispos. 2002 May;30(5):505-12.

4.

In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.

Vickers S, Duncan CA, Vyas KP, Kari PH, Arison B, Prakash SR, Ramjit HG, Pitzenberger SM, Stokker G, Duggan DE.

Drug Metab Dispos. 1990 Jul-Aug;18(4):476-83.

PMID:
1976071
5.

beta-Oxidation of simvastatin in mouse liver preparations.

Prueksaritanont T, Ma B, Fang X, Subramanian R, Yu J, Lin JH.

Drug Metab Dispos. 2001 Oct;29(10):1251-5.

6.

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, Kinoshita T, Saito N, Ochiai A, Tomita M, Esumi H, Soga T.

Cancer Res. 2009 Jun 1;69(11):4918-25. doi: 10.1158/0008-5472.CAN-08-4806. Epub 2009 May 19.

7.
8.

In vitro inhibition of simvastatin metabolism in rat and human liver by naringenin.

Ubeaud G, Hagenbach J, Vandenschrieck S, Jung L, Koffel JC.

Life Sci. 1999;65(13):1403-12.

PMID:
10503959
9.
10.

Effect of oral ketoconazole on oral and intravenous pharmacokinetics of simvastatin and its acid in cynomolgus monkeys.

Ogasawara A, Utoh M, Nii K, Ueda A, Yoshikawa T, Kume T, Fukuzaki K.

Drug Metab Dispos. 2009 Jan;37(1):122-8. doi: 10.1124/dmd.108.022574. Epub 2008 Oct 14.

11.

Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus.

Li X, Xu Z, Lu X, Yang X, Yin P, Kong H, Yu Y, Xu G.

Anal Chim Acta. 2009 Feb 9;633(2):257-62. doi: 10.1016/j.aca.2008.11.058. Epub 2008 Dec 3.

PMID:
19166731
12.

Effect of benidipine on simvastatin metabolism in human liver microsomes.

Sugiyama Y, Mimura N, Kuwabara T, Kobayashi H, Ushiki J, Fuse E.

Drug Metab Pharmacokinet. 2007 Jun;22(3):199-205.

13.

Metabolic profiling of infant urine using comprehensive two-dimensional gas chromatography: Application to the diagnosis of organic acidurias and biomarker discovery.

Kouremenos KA, Pitt J, Marriott PJ.

J Chromatogr A. 2010 Jan 1;1217(1):104-11. doi: 10.1016/j.chroma.2009.10.033. Epub 2009 Oct 20.

PMID:
19896671
14.

Acyl-coenzyme a formation of simvastatin in mouse liver preparations.

Li C, Subramanian R, Yu S, Prueksaritanont T.

Drug Metab Dispos. 2006 Jan;34(1):102-10. Epub 2005 Oct 26.

15.

One-pot microwave derivatization of target compounds relevant to metabolomics with comprehensive two-dimensional gas chromatography.

Kouremenos KA, Harynuk JJ, Winniford WL, Morrison PD, Marriott PJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1761-70. doi: 10.1016/j.jchromb.2010.04.036. Epub 2010 May 20.

PMID:
20493787
16.

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin.

Geboers S, Stappaerts J, Tack J, Annaert P, Augustijns P.

Int J Pharm. 2016 Aug 20;510(1):296-303. doi: 10.1016/j.ijpharm.2016.06.048. Epub 2016 Jun 20.

PMID:
27340029
17.

Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics.

Jacobs DM, Gaudier E, van Duynhoven J, Vaughan EE.

Curr Drug Metab. 2009 Jan;10(1):41-54. Review.

PMID:
19149512
18.

A rapid microwave-assisted derivatization of bacterial metabolome samples for gas chromatography/mass spectrometry analysis.

Liebeke M, Wunder A, Lalk M.

Anal Biochem. 2010 Jun 15;401(2):312-4. doi: 10.1016/j.ab.2009.04.030. Epub 2009 May 4.

PMID:
19397887
19.

Urinary metabonomics study in a rat model in response to protein-energy malnutrition by using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.

Wu Z, Li M, Zhao C, Zhou J, Chang Y, Li X, Gao P, Lu X, Li Y, Xu G.

Mol Biosyst. 2010 Nov;6(11):2157-63. doi: 10.1039/c005291d. Epub 2010 Aug 17.

PMID:
20717558
20.

The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats.

Zhang Z, Bu H, Gao Z, Huang Y, Gao F, Li Y.

Int J Pharm. 2010 Jul 15;394(1-2):147-53. doi: 10.1016/j.ijpharm.2010.04.039. Epub 2010 May 8.

PMID:
20435111

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